Results 201 to 210 of about 171,680 (341)

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

open access: yesEpilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls   +13 more
wiley   +1 more source

Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction

open access: yesThe FEBS Journal, EarlyView.
The damage caused by myocardial infarction is exacerbated in the absence of collagen XV and leads to pathological remodelling and more severe left ventricle dysfunction (left panel) compared with the wild‐type littermates. These changes are accompanied by a wide‐ranging impact, including phenotypical (middle panel) and molecular (right panel) changes ...
Sanna‐Maria Karppinen   +15 more
wiley   +1 more source

Microglial activation is inhibited by selective anti-seizure medications. [PDF]

open access: yesInflamm Res
Platow RJ   +5 more
europepmc   +1 more source

Pathology and Immunocytochemistry of a Kuru Brain [PDF]

open access: bronze, 1997
Johannes A. Hainfellner   +6 more
openalex   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

open access: yesThe FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner   +13 more
wiley   +1 more source

Pulegone induced apoptotic and anti-proliferative potential in cervical cancer via P53, BAX and BCL2. [PDF]

open access: yesSci Rep
Maqbool T   +9 more
europepmc   +1 more source

Techniques in Immunocytochemistry [PDF]

open access: yesJournal of Clinical Pathology, 1983
openaire   +1 more source

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