Results 61 to 70 of about 614,575 (264)

Role of Pore-Forming Toxins in Neonatal Sepsis

Clinical and Developmental Immunology, 2013
Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular ...
Andreas F.-P. Sonnen, Philipp Henneke
doaj   +1 more source

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2

Frontiers in Immunology, 2019
Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining ...
Christian Klemann, Christian Klemann, Nadezhda Camacho-Ordonez, Nadezhda Camacho-Ordonez, Linlin Yang, Zoya Eskandarian, Jessica L. Rojas-Restrepo, Natalie Frede, Alla Bulashevska, Maximilian Heeg, Maximilian Heeg, Moudjahed Saleh Al-Ddafari, Moudjahed Saleh Al-Ddafari, Julian Premm, Maximilian Seidl, Maximilian Seidl, Sandra Ammann, Sandra Ammann, Roya Sherkat, Nita Radhakrishnan, Klaus Warnatz, Susanne Unger, Robin Kobbe, Anja Hüfner, T. Ronan Leahy, Winnie Ip, Winnie Ip, Siobhan O. Burns, Siobhan O. Burns, Manfred Fliegauf, Manfred Fliegauf, Bodo Grimbacher, Bodo Grimbacher   +32 more
doaj   +1 more source

Superspreading, overdispersion and their implications in the SARS-CoV-2 (COVID-19) pandemic: a systematic review and meta-analysis of the literature

BMC Public Health, 2023
Background A recurrent feature of infectious diseases is the observation that different individuals show different levels of secondary transmission. This inter-individual variation in transmission potential is often quantified by the dispersion parameter
Oliver Wegehaupt, Akira Endo, Anna Vassall   +2 more
doaj   +1 more source

JAKs and STATs in immunity, immunodeficiency, and cancer.

New England Journal of Medicine, 2013
A large number of cytokines signal through the JAK–STAT pathway. Abnormal function of this pathway may lead to a variety of diseases. Targeting the defects in this signaling pathway has already led to treatment advances, and further advances are likely.
J. O’Shea, S. Holland, L. Staudt
semanticscholar   +1 more source

PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect

Frontiers in Immunology
BackgroundHypomorphic mutations in the phosphoacetylglucosamine mutase 3 (PGM3) gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy.
Linlin Yang, Linlin Yang, Barbara Zerbato, Alex Pessina, Luca Brambilla, Virginia Andreani, Stefanie Frey-Jakobs, Manfred Fliegauf, Mohamed-Ridha Barbouche, Mohamed-Ridha Barbouche, Qiaoxia Zhang, Ferdinando Chiaradonna, Michele Proietti, Michele Proietti, Michele Proietti, Xin Du, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +19 more
doaj   +1 more source

Health-Related Quality of Life in Primary Antibody Deficiency

Iranian Journal of Allergy, Asthma and Immunology, 2011
Patients  with  primary  antibody  deficiencies  (PAD)  are  susceptible  to  recurrent  and chronic infections and a variety of complications. This study was performed to assess quality of life (QoL) of PAD patients who were under long term treatment ...
Asghar Aghamohammadi, Ali Montazeri, Hassan Abolhassani, Sepideh Saroukhani, Sarvenaz Pourjabbar, Mahmoud Tavassoli, Behzad Darabi, Amir Imanzadeh, Nima Parvaneh, Nima Rezaei   +9 more
doaj  

Epidemiological Synergy: Interrelationships between Human Immunodeficiency Virus Infection and Other Sexually Transmitted Diseases

Sexually Transmitted Diseases, 1992
&NA; Understanding the role of other sexually transmitted diseases (STDs) in the transmission of human immunodeficiency virus (HIV), the role of STDs in progression of HIV disease, and the role of HIV infection in alterations of natural history ...
J. Wasserheit
semanticscholar   +1 more source

Guillain–Barré syndrome (GBS) after severe/critical COVID-19 or COVID-19 vaccination

European Journal of Medical Research
Background The global COVID-19 pandemic was initiated by the appearance of the novel coronavirus SARS-CoV-2 in 2019, presenting a spectrum of clinical manifestations from asymptomatic cases to severe pneumonia and multi-organ dysfunction, with some cases
Samira Bahrami, Behnaz Ansari, Leyla Norouzi-Barough, Bahram Bagherpour, Farzin Khorvash, Kiana Shirani, Saeed Abbasi, Roya Sherkat   +7 more
doaj   +1 more source

COVID-19 in a patient with Good's syndrome and in 13 patients with common variable immunodeficiency

Clinical Immunology Communications, 2021
Antibody deficiencies constitute the majority of primary immunodeficiencies in adults. These patients have a well-established increased risk of bacterial infections but there is a lack of knowledge regarding the relative risks upon contracting COVID-19 ...
Hannes Lindahl, C I Edvard Smith, Peter Bergman   +2 more
doaj  

Rapid Flow Cytometry-Based Test for the Diagnosis of Lipopolysaccharide Responsive Beige-Like Anchor (LRBA) Deficiency

Frontiers in Immunology, 2018
The diagnosis of lipopolysaccharide-responsive beige-like-anchor-protein (LRBA) deficiency currently relies on gene sequencing approaches that do not support a timely diagnosis and clinical management. We developed a rapid and sensitive test for clinical
Laura Gámez-Díaz, Laura Gámez-Díaz, Elena C. Sigmund, Veronika Reiser, Veronika Reiser, Werner Vach, Sophie Jung, Sophie Jung, Bodo Grimbacher, Bodo Grimbacher   +9 more
doaj   +1 more source