Results 81 to 90 of about 874,843 (291)

Role of Pore-Forming Toxins in Neonatal Sepsis

Clinical and Developmental Immunology, 2013
Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular ...
Andreas F.-P. Sonnen, Philipp Henneke
doaj   +1 more source

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2

Frontiers in Immunology, 2019
Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining ...
Christian Klemann, Christian Klemann, Nadezhda Camacho-Ordonez, Nadezhda Camacho-Ordonez, Linlin Yang, Zoya Eskandarian, Jessica L. Rojas-Restrepo, Natalie Frede, Alla Bulashevska, Maximilian Heeg, Maximilian Heeg, Moudjahed Saleh Al-Ddafari, Moudjahed Saleh Al-Ddafari, Julian Premm, Maximilian Seidl, Maximilian Seidl, Sandra Ammann, Sandra Ammann, Roya Sherkat, Nita Radhakrishnan, Klaus Warnatz, Susanne Unger, Robin Kobbe, Anja Hüfner, T. Ronan Leahy, Winnie Ip, Winnie Ip, Siobhan O. Burns, Siobhan O. Burns, Manfred Fliegauf, Manfred Fliegauf, Bodo Grimbacher, Bodo Grimbacher   +32 more
doaj   +1 more source

Pre-incubation of cell-free HIV-1 group M isolates with non-nucleoside reverse transcriptase inhibitors blocks subsequent viral replication in co-cultures of dendritic cells and T cells. [PDF]

, 2005
In order to study the inhibitory effect of various reverse transcriptase inhibitors (RTIs) on cell-free HIV, we adapted a recently described in vitro system, based on co-cultures of dendritic cells and resting CD4 T cells, modelling early target cells ...
Andries, Koen, Fransen, K., Garcia, S., Janssen, C.G.M., Janssen, P.A.J., Kestens, Luc, Lewi, Paul, Njai, H.F., Vanham, Guido   +8 more
core  

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection. [PDF]

, 2016
Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)-positive patients, as these patients are at heightened risk of developing TB.
Bangsberg, Butler, Campos, Carlton A. Evans, Caviedes, Daniela E. Kirwan, David A. J. Moore, Dooley, Eduardo Ticona, Escombe, Escombe, Evans, Franzblau, Hannan, Hu, Huang, Iwamoto, Jon S. Friedland, Jorge Coronel, Kawai, Lilia Z. Cabrera, Louis Grandjean, Luz Caviedes, Luz Huaroto, Matthew Z. Dudley, Mirko Zimic, Mitchison, Moore, Moore, Patricia Sheen, Raviglione, Richard Rodriguez, Robert H. Gilman, Scorpio, Sheen, Sheen, Sheen, Steele, Stricof, Víctor Chávez-Pérez, Wells, Willingham   +41 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Health-Related Quality of Life in Primary Antibody Deficiency

Iranian Journal of Allergy, Asthma and Immunology, 2011
Patients  with  primary  antibody  deficiencies  (PAD)  are  susceptible  to  recurrent  and chronic infections and a variety of complications. This study was performed to assess quality of life (QoL) of PAD patients who were under long term treatment ...
Asghar Aghamohammadi, Ali Montazeri, Hassan Abolhassani, Sepideh Saroukhani, Sarvenaz Pourjabbar, Mahmoud Tavassoli, Behzad Darabi, Amir Imanzadeh, Nima Parvaneh, Nima Rezaei   +9 more
doaj  

PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect

Frontiers in Immunology
BackgroundHypomorphic mutations in the phosphoacetylglucosamine mutase 3 (PGM3) gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy.
Linlin Yang, Linlin Yang, Barbara Zerbato, Alex Pessina, Luca Brambilla, Virginia Andreani, Stefanie Frey-Jakobs, Manfred Fliegauf, Mohamed-Ridha Barbouche, Mohamed-Ridha Barbouche, Qiaoxia Zhang, Ferdinando Chiaradonna, Michele Proietti, Michele Proietti, Michele Proietti, Xin Du, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher, Bodo Grimbacher   +19 more
doaj   +1 more source