Results 81 to 90 of about 863,721 (336)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Clinical and Laboratory Parameters of Autoinflammatory Disorders in Single Tertiary Care Center

Iranian Journal of Allergy, Asthma and Immunology, 2022
Autoinflammatory diseases (AIDs) are disorders with an inborn error of innate immunity, characterized by recurrent episodes of fever and inflammatory attacks.
Roya Sherkat, Alireza Rafiei, Vida Homayouni, Elmira Kalantari, Roya Sepahvandi, Sahar Memarmontazarin, Ali Mosayebian   +6 more
doaj  

“Immune TOR-opathies,” a Novel Disease Entity in Clinical Immunology

Frontiers in Immunology, 2018
Primary immunodeficiencies (PIDs) represent a group of mostly monogenic disorders caused by loss- or gain-of-function mutations in over 340 known genes that lead to abnormalities in the development and/or the function of the immune system.
Sophie Jung, Sophie Jung, Sophie Jung, Laura Gámez-Díaz, Michele Proietti, Bodo Grimbacher   +5 more
doaj   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Role of Pore-Forming Toxins in Neonatal Sepsis

Clinical and Developmental Immunology, 2013
Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular ...
Andreas F.-P. Sonnen, Philipp Henneke
doaj   +1 more source

Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2

Frontiers in Immunology, 2019
Non-canonical NF-κB-pathway signaling is integral in immunoregulation. Heterozygous mutations in NFKB2 have recently been established as a molecular cause of common variable immunodeficiency (CVID) and DAVID-syndrome, a rare condition combining ...
Christian Klemann, Christian Klemann, Nadezhda Camacho-Ordonez, Nadezhda Camacho-Ordonez, Linlin Yang, Zoya Eskandarian, Jessica L. Rojas-Restrepo, Natalie Frede, Alla Bulashevska, Maximilian Heeg, Maximilian Heeg, Moudjahed Saleh Al-Ddafari, Moudjahed Saleh Al-Ddafari, Julian Premm, Maximilian Seidl, Maximilian Seidl, Sandra Ammann, Sandra Ammann, Roya Sherkat, Nita Radhakrishnan, Klaus Warnatz, Susanne Unger, Robin Kobbe, Anja Hüfner, T. Ronan Leahy, Winnie Ip, Winnie Ip, Siobhan O. Burns, Siobhan O. Burns, Manfred Fliegauf, Manfred Fliegauf, Bodo Grimbacher, Bodo Grimbacher   +32 more
doaj   +1 more source

A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen‐Based Bioink for Skin Wound Healing Applied by a Handheld Dual‐Head Airbrush

Advanced Healthcare Materials, EarlyView.
A dual‐head airbrush‐based spraying device, combined with a fibrinogen bioink enriched with glycosaminoglycans and collagen, enables the delivery of biomaterials and cells to promote wound healing. This system demonstrates effective skin regeneration in vitro and in vivo, with comparable results to autografts.
Paula Pleguezuelos‐Beltrán, Daniel Nieto‐García, Carlos Chocarro‐Wrona, Juan de Vicente, Patricia Gálvez‐Martín, José Manuel Entrena, Elena López‐Ruiz, Juan Antonio Marchal   +7 more
wiley   +1 more source

Health-Related Quality of Life in Primary Antibody Deficiency

Iranian Journal of Allergy, Asthma and Immunology, 2011
Patients  with  primary  antibody  deficiencies  (PAD)  are  susceptible  to  recurrent  and chronic infections and a variety of complications. This study was performed to assess quality of life (QoL) of PAD patients who were under long term treatment ...
Asghar Aghamohammadi, Ali Montazeri, Hassan Abolhassani, Sepideh Saroukhani, Sarvenaz Pourjabbar, Mahmoud Tavassoli, Behzad Darabi, Amir Imanzadeh, Nima Parvaneh, Nima Rezaei   +9 more
doaj  

altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]

, 2018
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel, Leal Noval, Manuel, Ruiz-Mateos Carmona, Ezequiel, Tarancon Diez, Laura   +3 more
core   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source