Results 91 to 100 of about 723,902 (263)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury
Neural Regeneration Research, 2015 Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-acyl side chain.
Christian Witzel +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Details of the immunofluorescence stainings.
, 2019 Details of the immunofluorescence stainings.
Hanneke Buter (3481865) +12 more
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Antibodies used for immunofluorescence microscopy.
, 2014 Antibodies used for immunofluorescence microscopy.
Suraj Unniappan (235924) +5 more
core +1 more source
Primary antibodies used for immunofluorescence.
, 2015 Primary antibodies used for immunofluorescence.
Gail S. Prins (685341) +1 more
core +2 more sources
Фармация и фармакология (Пятигорск)Mitochondrial-targeted antioxidant SkQ1 demonstrates a high efficiency in animal models and potentially can be used for minimizing postoperative complications in an on-pump open-heart surgery.The aim of study was to the assessment of preservation degree ...
E. A. Senokosova +6 more
doaj +1 more source