Results 71 to 80 of about 129,949 (299)

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is considered a non‐immunogenic tumor, and immune checkpoint inhibitor monotherapy lacks efficacy in this disease. Radiotherapy (RT) can stimulate the immune system.
Azad, Abul, D'Costa, Zenobia, Diana, Angela, Dushek, Omer, Fokas, Emmanouil, Jones, Keaton, Kruger, Philipp, Liu, Stanley, McKenna, W. Gillies, Muschel, Ruth J., Sansom, Owen J., Yin Lim, Su   +11 more
core   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

OncoImmunology, 2020
The term ‘immunogenic cell death’ (ICD) denotes an immunologically unique type of regulated cell death that enables, rather than suppresses, T cell-driven immune responses that are specific for antigens derived from the dying cells. The ability of ICD to
Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi, Abhishek D. Garg   +10 more
doaj   +1 more source

Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor [PDF]

, 2018
derived cells (CDCs) are a cardiac progenitor cell population, which have been shown to possess cardiac regenerative properties and can improve heart function in a variety of cardiac diseases. Studies in large animal models have predominantly focussed on
A Augello, AJ Nauta, AJ Poncelet, AJ White, AS Boyd, B Hegyi, B Nadal-Ginard, C Basso, C Boriesson, C Liang, CH Chen, CY Xiao, D Carrade, D Pinheiro, DR Davis, DY Nah, E Ingulli, EM Oxford, G Couto de, G Wess, G Wess, GO Ramirez-Yañez, H Kanazawa, H Takeyama, I Chimenti, JA Dixon, JG Bartolucci, JM Angles, JW Kang, K Blanc Le, K Malliaras, K Malliaras, K Sato, KM Meurs, L Cambier, L Grigorian-Shamagian, L Lauden, L Öberg, LC Dutton, LJ Kennedy, M Haidar, MA Aminzadeh, MD Nicola, ME Bernardo, ME Campian, MM Duffy, MT Hensley, MT Hensley, N Kvirkvelia, O Campuzano, P Ross, PV Johnston, Q Guan, R Gallet, R Meisel, R Ramasamy, RR Makkar, S Aggarwal, S Simpson, SJ Jansen of Lorkeers, SR Houser, ST Lee, T Maślanka, TL Lynch, TS Li, WS Lee, Y Ding, Y Sun, YC Hsueh, Z Yan   +69 more
core   +2 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis. [PDF]

, 2018
Binding of small molecules in the human leukocyte antigen (HLA) peptide-binding groove may result in conformational changes of bound peptide and an altered immune response, but previous studies have not considered a potential role for endogenous ...
Damotte, Vincent, Hollenbach, Jill, Misra, Maneesh   +2 more
core   +1 more source

Solid-state electron-mediated z-scheme heterostructured semiconductor nanomaterials induce dual programmed cell death for melanoma therapy

Journal of Nanobiotechnology
The programmed cell death (PCD) pathway removes functionally insignificant, infection-prone, or potentially tumorigenic cells, underscoring its important role in maintaining the stability of the internal environment and warding off cancer and a host of ...
Yiping Ren, Yun Wang, Cheng Chen, Xiang Yan, Minghao Chao, Yuting Li, Dehong Yu, Yuqi Huang, Xiaoyang Hou, Fenglei Gao, Guan Jiang, Ming Guan   +11 more
doaj   +1 more source

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]

, 2011
Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia, Garg, Abhishek D, Krysko, Dmitri, Vandenabeele, Peter   +3 more
core   +1 more source

Potentiation of the abscopal effect by modulated electro-hyperthermia in locally advanced cervical cancer patients [PDF]

, 2020
Background: A Phase III randomized controlled trial investigating the addition of modulated electro-hyperthermia (mEHT) to chemoradiotherapy for locally advanced cervical cancer patients is being conducted in South Africa (Human Research Ethics Committee
Ayeni, Olusegun, Baeyens, Ans, Kotzen, Jeffrey, Minnaar, Carrie Anne, Vangu, Mboyo-Di-Tamba   +4 more
core   +2 more sources