Results 221 to 230 of about 456,487 (388)

THE REQUIREMENT OF MORE THAN ONE ANTIGENIC DETERMINANT FOR IMMUNOGENICITY [PDF]

, 1969
Klaus Rajewsky, Volker Schirrmacher, S. Nase, N. K. Jerne   +3 more
openalex   +1 more source

A Targeted Redox‐Active Dual‐Action Pt(IV)‐Mn(II) Prodrug Displays Enhanced In Vivo Anticancer Activity

Advanced Healthcare Materials, EarlyView.
A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez, Henri Chédotal, Ram Pravin Kumar Muthuramalingam, Marine Thomas, Jia Ning Nicolette Yau, Priya Ranjan Sahoo, Clotilde Policar, Frédéric Batteux, Kadda Medjoubi, Andrea Somogyi, Giulia Adriani, Carole Nicco, Romain Coriat, Giorgia Pastorin, Hélène C. Bertrand   +14 more
wiley   +1 more source

STUDIES ON THE HETEROLOGOUS IMMUNOGENICITY OF A METHANOL-INSOLUBLE FRACTION OF ATTENUATED TUBERCLE BACILLI (BCG) [PDF]

, 1966
David Weiss, Rose S. Bonhag, P. H. Leslie   +2 more
openalex   +1 more source

DNA Barcoding‐Enabled Tracking of Lipid Nanoparticles: Drug‐Loading‐Dependent Biodistribution and Tumor Microenvironment Targeting

Advanced Healthcare Materials, EarlyView.
In this study, lipid nanoparticles are tracked in vivo using DNA barcodes to determine how varying drug loadings affect their delivery behaviors in mice. A cost‐effective strategy is developed for simultaneously monitoring the biodistribution of a library of lipid nanoparticles (LNPs).
Letao Xu, Rui Chen, Xing Wang, Dawei Liu, Yun liu, Chun‐Xia Zhao   +5 more
wiley   +1 more source

Immunogenicity of Cell Walls from Various Mycobacteria Against Airborne Tuberculosis in Mice [PDF]

, 1968
W Brehmer, R. L. Anacker, Edgar Ribi
openalex   +1 more source

Immunogenicity of CAR T cells in cancer therapy

Nature Reviews Clinical Oncology, 2021
D. Wagner, Enrico Fritsche, M. Pulsipher, N. Ahmed, Mohamad Hamieh, M. Hegde, M. Ruella, B. Savoldo, N. Shah, C. Turtle, A. Wayne, M. Abou-el-Enein   +11 more
semanticscholar   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

The Immunogenicity of Hapten-Polylysine Conjugates [PDF]

, 1965
Christopher Parker, J. A. Thiel, Sylvia Mitchell   +2 more
openalex   +1 more source

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury

Advanced Healthcare Materials, EarlyView.
A decellularized nerve graft (DNG) is modified to generate a porous DNG (PDNG). The PDNG is used to repair a 30‐mm peripheral nerve injury (PNI) defect, and is compared with isograft, serving as the standard, and DNG, a widely used alternative. The result shows that PDNG facilitated nerve regeneration in long‐gap PNI, evidenced by better‐aligned axonal
Olawale Alimi Alimi, Mitchell Kuss, Wen Xue, Bo Liu, Mena Asha Krishnan, Tianshu Pan, Zhi He, Han‐Jun Wang, Yuguo Lei, Kai Yang, Bin Duan   +10 more
wiley   +1 more source

Immunogenic Study in Antitumor Antibody Production against Transplantable Tumors

, 1963
Kiyoshi Takeda
openalex   +4 more sources