Results 21 to 30 of about 315,728 (345)

Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2

Annals of Internal Medicine, 2021
Evidence suggests that immunogenicity to mRNA-based SARS-CoV-2 vaccination in immunosuppressed patients may be reduced. This study assessed the response to 2 doses of mRNA-based SARS-CoV-2 vaccine among 133 participants with underlying chronic ...
P. Deepak, Wooseob Kim, Michael A. Paley, Monica M. Yang, A. Carvidi, Emanuel Demissie, Alia A. El-Qunni, Alem Haile, Katherine Huang, Baylee Kinnett, Mariel J. Liebeskind, Zhuoming Liu, L. McMorrow, D. Páez, Niti Pawar, D. Perantie, Rebecca E. Schriefer, Shannon E. Sides, Mahima Thapa, M. Gergely, Suha Abushamma, Sewuese Akuse, Michael K Klebert, Lynne M. Mitchell, D. Nix, J. Graf, K. Taylor, S. Chahin, M. Ciorba, P. Katz, M. Matloubian, Jane A. O’Halloran, R. Presti, Gregory F. Wu, S. Whelan, W. Buchser, L. Gensler, Mary C. Nakamura, A. Ellebedy, A. H. Kim   +39 more
semanticscholar   +1 more source

Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19.

Journal of the American Medical Association (JAMA), 2021
Importance Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines. Objective To evaluate the immunogenicity of the Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) in humans, including the ...
K. Stephenson, Mathieu le Gars, J. Sadoff, A. M. de Groot, Dirk Heerwegh, C. Truyers, C. Atyeo, C. Loos, A. Chandrashekar, K. McMahan, Lisa H. Tostanoski, Jingyou Yu, M. Gebre, C. Jacob-Dolan, Zhenfeng Li, Shivani Patel, Lauren Peter, Jinyan Liu, E. Borducchi, Joseph P. Nkolola, Morgana Souza, C. Tan, Rebecca Zash, B. Julg, R. Nathavitharana, R. Shapiro, Ahmed Abdul Azim, C. Alonso, K. Jaegle, J. Ansel, Diane G Kanjilal, Caitlin J. Guiney, C. Bradshaw, Anna Tyler, Tatenda Makoni, Katherine E. Yanosick, M. Seaman, D. Lauffenburger, G. Alter, F. Struyf, M. Douoguih, J. van Hoof, H. Schuitemaker, D. Barouch   +43 more
semanticscholar   +1 more source

Learn–confirm in model‐informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform

CPT: Pharmacometrics & Systems Pharmacology, 2023
Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and safety.
Linnea C. Franssen, Maciej J. Swat, Andrzej M. Kierzek, Rachel H. Rose, Piet H. van derGraaf, Hans Peter Grimm   +5 more
doaj   +1 more source

Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021
The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity ...
K. Abu Jabal, H. Ben-Amram, K. Beiruti, Yunis Batheesh, Christian Sussan, S. Zarka, M. Edelstein   +6 more
semanticscholar   +1 more source

Immunogenicity of biopharmaceuticals [PDF]

Nephrology Dialysis Transplantation, 2006
The availability of biopharmaceuticals has been increasing over the past decade and as their patents expire, the emergence of biosimilar agents approaches. The primary issue of concern for the safety of these agents is the potential for immunogenicity.
Huub Schellekens, Michèle Kessler, David Goldsmith   +2 more
openaire   +2 more sources

Trastuzumab immunogenicity development in patients’ sera and in laboratory animals

BMC Immunology, 2021
Background Immunogenicity is a major challenge in drug development and patient care. Clinicians and regulators are familiar with immunogenicity concerns of monoclonal antibody (mAb) therapeutics, growth factors and enzyme replacements.
Lobna Abdel Aziz Kilany, Ayman Abdel Samie Gaber, Mohammad Mabrouk Aboulwafa, Hamdallah Hafez Zedan   +3 more
doaj   +1 more source

Immunogenicity of sulfatide [PDF]

Immunochemistry, 1977
Abstract The present study deals with the immunogenicity of sulfatide. Despite its acidic character, we succeeded in raising high titer antibodies. The most effective immunization procedure involved repeated intravenous injections of a mixture of sulfatide-lecithin-cholesterol-methylated bovibe serum albumin (1:4:10:10).
B. Zalc, B. Zalc, C. Jacque, C. Jacque, Norman S. Radin, Norman S. Radin, P. Dupouey, P. Dupouey   +7 more
openaire   +4 more sources

Immunogenicity of botulinum toxin [PDF]

Archives of Plastic Surgery, 2022
Botulinum toxin treatment is the most common non-surgical cosmetic treatment. Although there are many available treatments using botulinum toxin, their effects are temporary and repeated injections are required. These frequent injections can trigger an immunological response. In addition, botulinum toxin acts as an antigen in the body; thus, its effect
Syeo Young Wee, Eun Soo Park
openaire   +3 more sources

Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials.

Journal of the American Medical Association (JAMA), 2020
Importance A vaccine against coronavirus disease 2019 (COVID-19) is urgently needed. Objective To evaluate the safety and immunogenicity of an investigational inactivated whole-virus COVID-19 vaccine in China.
S. Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Z. Xie, Xinguo Li, Cheng Peng, Yan-Bo Zhang, Wei Zhang, Y. Yang, Wei Chen, Xiaoxiao Gao, W. You, Xuewei Wang, Zejun Wang, Zhengli Shi, Yanxia Wang, Xuqin Yang, Lianghao Zhang, Lili Huang, Qian Wang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, X. Wan, Cong Wu, Wenhui Wang, Shihe Huang, Jianhui Du, Z. Meng, A. Pan, Zhiming Yuan, S. Shen, Wanshen Guo, Xiaoming Yang   +36 more
semanticscholar   +1 more source

Immunogenicity and toxicity of AAV gene therapy

Frontiers in Immunology, 2022
Gene transfer using adeno-associated viral (AAV) vectors has made tremendous progress in the last decade and has achieved cures of debilitating diseases such as hemophilia A and B.
H. Ertl
semanticscholar   +1 more source