Results 41 to 50 of about 319,900 (371)

Understanding the Supersensitive Anti-Drug Antibody Assay: Unexpected High Anti-Drug Antibody Incidence and Its Clinical Relevance

Journal of Immunology Research, 2016
Numbers of biotherapeutic products in development have increased over past decade. Despite providing significant benefits to patients with unmet needs, almost all protein-based biotherapeutics could induce unwanted immunogenicity, which result in a loss ...
Sam Song, Lili Yang, William L. Trepicchio, Timothy Wyant   +3 more
doaj   +1 more source

Predicting HLA CD4 Immunogenicity in Human Populations

Frontiers in Immunology, 2018
BackgroundPrediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications.
Sandeep Kumar Dhanda, Edita Karosiene, Lindy Edwards, Alba Grifoni, Sinu Paul, Massimo Andreatta, Daniela Weiskopf, John Sidney, Morten Nielsen, Morten Nielsen, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +13 more
doaj   +1 more source

Efficacy, Immunogenicity and Safety of COVID-19 Vaccines: A Systematic Review and Meta-Analysis

Frontiers in Immunology, 2021
There is a significant research gap in meta-analysis on the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccines. This study analyzed the efficacy of COVID-19 vaccines. Published phase I, phase II, and phase III trials analyzing safety and
N. Sharif, Khalid J. Alzahrani, Shamsun Nahar Ahmed, S. Dey   +3 more
semanticscholar   +1 more source

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Nature Communications, 2017
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear.
C. Vanpouille-Box, A. Alard, M. Aryankalayil, Yasmeen Sarfraz, J. Diamond, R. Schneider, G. Inghirami, C. Coleman, S. Formenti, S. Demaria   +9 more
semanticscholar   +1 more source

Applying MAPPs Assays to Assess Drug Immunogenicity

Frontiers in Immunology, 2020
Immunogenicity against biotherapeutic proteins (BPs) and the potential outcome for the patient are difficult to predict. In vitro assays that can help to assess the immunogenic potential of BPs are not yet used routinely during drug development.
Anette C. Karle
doaj   +1 more source

Immunogenicity of a DNA vaccine candidate for COVID-19

Nature Communications, 2020
The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease.
Trevor R. F. Smith, Ami Patel, S. Ramos, Dustin Elwood, Xizhou Zhu, Jian Yan, E. Gary, Susanne N. Walker, K. Schultheis, M. Purwar, Ziyang Xu, Jewell N. Walters, Pratik S. Bhojnagarwala, Maria Yang, Neethu Chokkalingam, P. Pezzoli, Elizabeth M. Parzych, E. Reuschel, Arthur Doan, Nicholas J. Tursi, Miguel A. Vasquez, Jihae Choi, Edgar Tello-Ruiz, I. Maričić, Mamadou A. Bah, Yuanhan Wu, D. Amante, Daniel H. Park, Yaya D. Dia, A. Ali, F. Zaidi, Alison Generotti, Kevin Y. Kim, T. Herring, Sophia M. Reeder, V. Andrade, K. Buttigieg, Gan Zhao, Jiun‐Ming Wu, Dan Li, L. Bao, Jiangning Liu, Wei Deng, C. Qin, Ami Shah Brown, M. Khoshnejad, Nianshuang Wang, Jacqueline D. Chu, D. Wrapp, Jason S. McLellan   +49 more
semanticscholar   +1 more source

Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications

Journal of Immunology Research, 2016
Today, potential immunogenicity can be better evaluated during the drug development process, and we have rational approaches to manage the clinical consequences of immunogenicity.
Anshu Kuriakose, Narendra Chirmule, Pradip Nair   +2 more
doaj   +1 more source

Presentation of antigen on extracellular vesicles using transmembrane domains from viral glycoproteins for enhanced immunogenicity

Journal of Extracellular Vesicles, 2022
A vaccine antigen, when launched as DNA or RNA, can be presented in various forms, including intracellular, secreted, membrane‐bound, or on extracellular vesicles (EVs).
Kai Hu, Paul F. McKay, Karnyart Samnuan, Adrian Najer, Anna K. Blakney, Junyi Che, Gwen O'Driscoll, Martina Cihova, Molly M. Stevens, Robin J. Shattock   +9 more
doaj   +1 more source

Design and expression of TolC as a recombinant protein vaccine against Shigella flexneri and evaluation of immunogenic response in mice [PDF]

arXiv, 2023
Background: Shigella is one of the major cause of dysenteric diarrhea, which is known shigelosis. Shigelosis causes 160,000 deaths annually of diarrheal disease in a global scale especially children less than 5 years old. No licensed vaccine is available against shigelosis, therefore, efforts for develop an effective and safe vaccine against shigella ...
arxiv  

Immunogenicity Risk Profile of Nanobodies

Frontiers in Immunology, 2021
Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a promising class of therapeutics or in vivo imaging reagents entering the clinic.
Chloé Ackaert, Natalia Smiejkowska, C. Xavier, Yann G. J. Sterckx, S. Denies, B. Stijlemans, Y. Elkrim, N. Devoogdt, V. Caveliers, T. Lahoutte, S. Muyldermans, K. Breckpot, M. Keyaerts   +12 more
semanticscholar   +1 more source