Results 41 to 50 of about 315,728 (345)

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Nature Communications, 2017
Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. However, the mechanisms by which radiation induces anti-tumour T cells remain unclear.
C. Vanpouille-Box, A. Alard, M. Aryankalayil, Yasmeen Sarfraz, J. Diamond, R. Schneider, G. Inghirami, C. Coleman, S. Formenti, S. Demaria   +9 more
semanticscholar   +1 more source

Predicting HLA CD4 Immunogenicity in Human Populations

Frontiers in Immunology, 2018
BackgroundPrediction of T cell immunogenicity is a topic of considerable interest, both in terms of basic understanding of the mechanisms of T cells responses and in terms of practical applications.
Sandeep Kumar Dhanda, Edita Karosiene, Lindy Edwards, Alba Grifoni, Sinu Paul, Massimo Andreatta, Daniela Weiskopf, John Sidney, Morten Nielsen, Morten Nielsen, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +13 more
doaj   +1 more source

Immunogenicity of Biotherapeutics: Causes and Association with Posttranslational Modifications

Journal of Immunology Research, 2016
Today, potential immunogenicity can be better evaluated during the drug development process, and we have rational approaches to manage the clinical consequences of immunogenicity.
Anshu Kuriakose, Narendra Chirmule, Pradip Nair   +2 more
doaj   +1 more source

Immunogenicity of a DNA vaccine candidate for COVID-19

Nature Communications, 2020
The coronavirus family member, SARS-CoV-2 has been identified as the causal agent for the pandemic viral pneumonia disease, COVID-19. At this time, no vaccine is available to control further dissemination of the disease.
Trevor R. F. Smith, Ami Patel, S. Ramos, Dustin Elwood, Xizhou Zhu, Jian Yan, E. Gary, Susanne N. Walker, K. Schultheis, M. Purwar, Ziyang Xu, Jewell N. Walters, Pratik S. Bhojnagarwala, Maria Yang, Neethu Chokkalingam, P. Pezzoli, Elizabeth M. Parzych, E. Reuschel, Arthur Doan, Nicholas J. Tursi, Miguel A. Vasquez, Jihae Choi, Edgar Tello-Ruiz, I. Maričić, Mamadou A. Bah, Yuanhan Wu, D. Amante, Daniel H. Park, Yaya D. Dia, A. Ali, F. Zaidi, Alison Generotti, Kevin Y. Kim, T. Herring, Sophia M. Reeder, V. Andrade, K. Buttigieg, Gan Zhao, Jiun‐Ming Wu, Dan Li, L. Bao, Jiangning Liu, Wei Deng, C. Qin, Ami Shah Brown, M. Khoshnejad, Nianshuang Wang, Jacqueline D. Chu, D. Wrapp, Jason S. McLellan   +49 more
semanticscholar   +1 more source

Applying MAPPs Assays to Assess Drug Immunogenicity

Frontiers in Immunology, 2020
Immunogenicity against biotherapeutic proteins (BPs) and the potential outcome for the patient are difficult to predict. In vitro assays that can help to assess the immunogenic potential of BPs are not yet used routinely during drug development.
Anette C. Karle
doaj   +1 more source

BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning

mAbs, 2022
Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains one of the main routes for therapeutic antibody development.
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil, Danny A. Bitton   +6 more
doaj   +1 more source

Pegylation Reduces the Uptake of Certolizumab Pegol by Dendritic Cells and Epitope Presentation to T-Cells

Frontiers in Immunology, 2022
Pegylation of biopharmaceuticals is the most common strategy to increase their half-life in the blood and is associated with a reduced immunogenicity. As antigen presentation is a primary event in the activation of CD4 T-cells and initiation of Anti-Drug
Marie de Bourayne, Sylvain Meunier, Samuel Bitoun, Evelyne Correia, Xavier Mariette, Hervé Nozach, Bernard Maillère   +6 more
doaj   +1 more source

Immunogenicity of botulinum toxins [PDF]

Journal of Neural Transmission, 2012
Botulinum neurotoxins are formulated biologic pharmaceuticals used therapeutically to treat a wide variety of chronic conditions, with varying governmental approvals by country. Some of these disorders include cervical dystonia, post-stroke spasticity, blepharospasm, migraine, and hyperhidrosis.
Naumann, Markus, Boo, Lee Ming, Ackerman, Alan H., Gallagher, Conor J.   +3 more
openaire   +3 more sources

Residual Bioprosthetic Valve Immunogenicity: Forgotten, Not Lost

Frontiers in Cardiovascular Medicine, 2022
Despite early realization of the need to control inherent immunogenicity of bioprosthetic replacement heart valves and thereby mitigate the ensuing host response and its associated pathology, including dystrophic calcification, the problem remains ...
Paul Human, Paul Human, Deon Bezuidenhout, Deon Bezuidenhout, Elena Aikawa, Peter Zilla, Peter Zilla, Peter Zilla   +7 more
doaj   +1 more source

Molecular characterization of a Trichinella spiralis serine proteinase

Veterinary Research, 2020
The aim of this study was to investigate the biological characteristics and functions of a Trichinella spiralis serine proteinase (TsSerp) during larval invasion and development in the host.
Xin Yue, Xiang Yuan Sun, Fang Liu, Chen Xi Hu, Ying Bai, Qi Da Yang, Ruo Dan Liu, Xi Zhang, Jing Cui, Zhong Quan Wang   +9 more
doaj   +1 more source