Results 51 to 60 of about 319,900 (371)
Immunogenicity of Extracellular Vesicles
Advances in MaterialsExtracellular vesicles (EVs) are promising next‐generation therapeutics and drug delivery systems due to demonstrated safety and efficacy in preclinical models and early‐stage clinical trials. There is an urgent need to address the immunogenicity of EVs (
Yutian Xia +3 more
semanticscholar +1 more source
Algorithm for optimized mRNA design improves stability and immunogenicity [PDF]
Nature, 2020 An algorithm based on concepts established in computational linguistics enables rapid principled design of mRNA vaccines optimizing both structural stability and codon usage, resulting in improved half-life, protein expression and immune responses ...
He Zhang +15 more
semanticscholar +1 more source
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper
Molecular Therapy: Methods & Clinical Development, 2022 Immunogenicity has imposed a challenge to efficacy and safety evaluation of adeno-associated virus (AAV) vector-based gene therapies. Mild to severe adverse events observed in clinical development have been implicated with host immune responses against ...
Tong-yuan Yang +18 more
doaj
Immunogenicity of Endolysin PlyC
Antibiotics, 2022 Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms. Since non-human proteins are efficient inducers of specific immune responses, including the IgG response or the development of an allergic response mediated ...
Marek Adam Harhala +4 more
openaire +3 more sources
Population-specific design of de-immunized protein biotherapeutics [PDF]
, 2017 Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic design is therefore to identify mutants of the protein sequence that minimize immunogenicity in a target population whilst retaining pharmaceutical activity and protein ...
arxiv +1 more source
Immunogenicity and humanization of single‐domain antibodies
The FEBS Journal, 2021 Single‐domain antibodies (sdAbs), the autonomous variable domains of camelid and shark heavy‐chain antibodies, have many desirable properties as components of biologic drugs.
M. Rossotti +3 more
semanticscholar +1 more source
A dermatologist guide to immunogenicity
International Journal of Women's Dermatology, 2016 Dermatologists should be aware that autoantibody formation may occur after the initiation of biologic therapy. This phenomenon has been referred to as immunogenicity and biologic fatigue. Because of this, patients may experience loss of clinical efficacy to a particular drug.
Soham P. Chaudhari +3 more
openaire +4 more sources
On the definition of a criterion of immunogenicity [PDF]
Proceedings of the National Academy of Sciences, 2006 The main objective of immunology is to establish why and when an immune response occurs, that is, to determine a criterion of immunogenicity. According to the consensus view, the proper criterion of immunogenicity lies in the discrimination between self and nonself.
Pradeu, Thomas, Carosella, Edgardo
openaire +5 more sources
Annals of the Rheumatic Diseases, 2021 Patients with rheumatic diseases are at increased risk of infectious complications; vaccinations are a critical component of their care. Disease-modifying antirheumatic drugs may reduce the immunogenicity of common vaccines. We will review here available
M. Friedman, J. Curtis, K. Winthrop
semanticscholar +1 more source
Immunogenicity of infliximab and adalimumab [PDF]
Expert Opinion on Drug Safety, 2019 TNF-α inhibitors have demonstrated efficacy both as monotherapy and in combination with disease-modifying anti-rheumatic drugs (DMARDs) in the treatment of chronic inflammatory immune-mediated dise...
Murdaca G. +6 more
openaire +5 more sources