Results 51 to 60 of about 405,820 (289)

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Feeding dietary inclusion of inulin on immune status, protein metabolism, and growth performance of Kedu chicken

Journal of the Indonesian Tropical Animal Agriculture
Indonesian Indigenous poultry originated from the central part of Java Island, called Kedu chick-en, given diet added with inulin of dahlia tuber extract (IDTE) to evaluate body resistance and protein deposition.
N. Suthama, I. Mangisah, L. Krismiyanto, V. D. Yunianto, M. Mulyono   +4 more
doaj   +1 more source

Intersection of Coeliac Disease and Sjogren’s Syndrome: A Report of Two Cases [PDF]

Journal of Clinical and Diagnostic Research
Coeliac Disease (CD) and Sjogren’s Syndrome (SS), both autoimmune disorders, are gaining attention for their complex interaction when occurring together.
Ravi Talapa, Rebecca Hoineikim Baite, Rishabh Rawat, Rohit Saini   +3 more
doaj   +1 more source

Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection

Gut Microbes, 2021
Secretory immunoglobulin A (IgA) interacts with intestinal microbiota and promotes mucosal homeostasis. IgA-bacteria interactions are altered during inflammatory diseases, but how these interactions are shaped by bacterial, host, and environmental ...
Kelsey E Huus, Marcin Frankowski, Maja Pučić-Baković, Frano Vučković, Gordan Lauc, Benjamin H Mullish, Julian R Marchesi, Tanya M Monaghan, Dina Kao, B. Brett Finlay   +9 more
doaj   +1 more source

IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications [PDF]

, 2019
The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples ...
Amato, Teresa, Aversa, Sara, Bellan, Cristiana, Cencini, Emanuele, Cevenini, Gabriele, DI NAPOLI, Arianna, Di Stefano, Gioia, Giulio Carta, Alberto, Granai, Massimo, Kovalchuk, Sofya, Lazzi, Stefano, Leoncini, Lorenzo, Mancini, Virginia, Santi, Raffaella, Vergoni, Federica, Ziepert, Marita   +15 more
core   +2 more sources

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

Serum immunoglobulin levels and risk of antibiotic prescription in middle-aged and older individuals: A population-based cohort study

Clinical Immunology Communications, 2023
: Objectives: Elderly become more susceptible to lower respiratory tract infections, resulting in antibiotic prescriptions. Immunoglobulins (Ig) play an important role in host defense and protection against infections. Therefore, we aimed to investigate
Anna Vanoverschelde, Samer R. Khan, Virgil A.S.H. Dalm, Layal Chaker, Guy Brusselle, Bruno H. Stricker, Lies Lahousse   +6 more
doaj   +1 more source

Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy. [PDF]

, 2013
ObjectivesTo examine the impact of serum-derived bovine immunoglobulin, an oral medical food known to neutralize bacterial antigen and reduce intestinal inflammation, on restoration of mucosal immunity and gastrointestinal function in individuals with ...
Albanese, Anthony, Asmuth, David M, Devaraj, Sridevi, Douek, Daniel C, Flynn, Neil M, Garcia, Juan-Carlos, Knight, Thomas H, Ma, Zhong-Min, Miller, Christopher J, Sandler, Netanya G, Tsuchida, Emily, Wu, Tsung-Teh, Yotter, Tammy   +12 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Corticosterone selectively decreases humoral immunity in female eiders during incubation

, 2007
Immunity is hypothesized to share limited resources with other physiological functions and this may partly account for the fitness costs of reproduction.
Bourgeon, Sophie, Raclot, Thierry
core   +1 more source