Results 71 to 80 of about 23,564,722 (387)

Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma

Nature Communications, 2015
Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood.
Bhairavi Swaminathan, G. Thorleifsson, Magnus Jöud, Mina Ali, E. Johnsson, Ram Ajore, P. Sulem, Britta Halvarsson, G. Eyjolfsson, V. Haraldsdóttir, C. Hultman, E. Ingelsson, S. Kristinsson, A. Kähler, S. Lenhoff, G. Másson, U. Mellqvist, R. Månsson, Sven Nelander, I. Olafsson, Ólöf Sigurðardóttir, H. Steingrímsdóttir, A. Vangsted, U. Vogel, A. Waage, H. Nahi, D. Gudbjartsson, T. Rafnar, I. Turesson, U. Gullberg, K. Stefánsson, M. Hansson, U. Thorsteinsdóttir, B. Nilsson   +33 more
semanticscholar   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Immunofluorescent Examination of Biopsies from Long-Term Renal Allografts [PDF]

, 1970
Immunofluorescent examination of open renal biopsies revealed clear-cut glomerular localization of immunoglobulins not related clearly to the quality of donor-recipient histocompatibility in 19 of 34 renal allografts.
Busch, Edgington, F. J. Dixon, J. J. McPhaul, L. Brettschneider, Peterson, Porter, Porter, Starzl, T. E. Starzl   +9 more
core   +1 more source

Effectiveness of Revised Trauma-Focused Cognitive Behavioral Therapy Protocol on Psychological Distress and Immunoglobulin A Concentration in Women Victims of Domestic Violence

Armaghane Danesh Bimonthly Journal, 2022
Background & aim: Domestic violence has been one of the most common social harms throughout human history, and due to its widespread effect, the pathology and treatment of this phenomenon has always been the focus of therapists. Therefore, the purpose of
SZ Kazemi Khoban, H Poursharifi, A Kakavand, M Xian Bagheri   +3 more
doaj  

Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia

JAMA Network Open, 2018
Key Points Question In patients receiving rituximab, what are the current rates of screening and recognition of hypogammaglobulinemia, and what are the infectious risks and predictors for increased mortality?
Sara Barmettler, Mei‐Sing Ong, Jocelyn R. Farmer, Hyon K. Choi, J. Walter   +4 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells

Gut Microbes
IgA binding dictates the composition of the intestinal microbiome and reflects dysbiotic states during chronic disease. Both pathogenic and commensal bacteria differentially bind to IgA with varying outcomes.
Nicolas Vitari, Salma Singh, Junyi Tao, Bridget Truitt, Udhghatri Kolli, Richa Jalodia, Kathryn M LaPorte, Yaa Abu, Danielle Antoine, Umakant Sharma, Sabita Roy   +10 more
doaj   +1 more source

Anti-inflammatory and immunomodulating effects of the bacterial lysate in the in vivo models of aseptic lymphadenitis and pneumococcal pneumonia

Медицинская иммунология, 2020
Bacterial lysates may produce immunoregulatory effects in the inflammatory diseases that are not directly caused by infectious agents; they may also stimulate the immune response against pathogens which are not a part of the lysate composition.
K. L. Kryshen, A. E. Kukharenko, A. S. Vichare, E. A. Gaidai, A. A. Kryshen, Ya. A. Gushchin, O. V. Kalyuzhin, M. N. Makarova, V. G. Makarov, B. Mahadevan   +9 more
doaj   +1 more source

Immunoglobulin A

mAbs, 2011
Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted
J. Bakema, M. van Egmond
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source