Results 71 to 80 of about 19,118,362 (293)

A Fluorescent Biosensor Reveals Conformational Changes in Human Immunoglobulin E Fc

Journal of Biological Chemistry, 2012
Background: Immunoglobulin E (IgE) antibodies play a role in allergic disease. Results: IgE has a bent conformation in solution that becomes more bent upon binding to the FcϵRI receptor but less bent upon binding the anti-IgE omalizumab.
J. Hunt, A. H. Keeble, R. Dale, M. Corbett, R. Beavil, J. Levitt, M. Swann, K. Suhling, S. Ameer-Beg, B. Sutton, A. Beavil   +10 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Correlating Salivary Levels of Immunoglobin E and Human Eosinophil Cationic Protein in the Aseer Cohort with Recurrent Apthous Stomatitis

International Journal of General Medicine, 2023
Khalil Assiri,1 Jagadish Hosmani,1 Sandeepa Nuchilakath Chalikkandy,1 Abdullah M Alkahtani,2 Raghad Mohammed Alhanif,3 Sarah Ahmed Alsarh,3 Shankargouda Patil,4 Rodolfo Reda,5 Luca Testarelli5 1Department of Diagnostic Dental Sciences, College of ...
Assiri K, Hosmani J, Chalikkandy SN, Alkahtani AM, Alhanif RM, Alsarh SA, Patil S, Reda R, Testarelli L   +8 more
doaj  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma [Corrigendum]

Journal of Asthma and Allergy, 2023
Ko FWS, Wang JKL, Hui DSC, et al. J Asthma Allergy. 2023;16:173-182. The authors have advised there is an error in Table 1. Table 1 on Page 177, in the third-to-last row, data addressing Median (IQR) for Eosinophil count, cells/mm3 should read from 3.2 ...
Ko FWS, Wang JKL, Hui DSC, Chan JWM, Cheung PS, Yeung YC, Sin KM, Ip MSM   +7 more
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The role of immunological biomarkers in the pathogenesis of atopic bronchial asthma [PDF]

Pediatric Anesthesia and Critical Care Journal (PACCJ)
Introduction The identification of reliable biomarkers for bronchial asthma, particularly in pediatric patients, is a topic of growing interest. This is primarily due to diagnostic chal- lenges in children, including limited capabilities for pul- monary
T. T. Panahova
doaj   +1 more source

[Clinical efficacy of omalizumab for treatment of moderate or severe allergic asthma in children with serum immunoglobulin E levels >1 500 IU/mL: a prospective study]. [PDF]

, 2023
Ming-Xin Luo, Hua Shan, Wen Wei
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source