Results 81 to 90 of about 19,497,476 (292)

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice [PDF]

, 1994
We have examined the regulatory role of the individual components of the immunoglobulin antigen receptor in B-cell development by transgenic complementation of Rag-1 deficient (Rag-1⁻) mice. Complementation with a membrane µ heavy chain (µHC) gene allows
Baltimore, David, Corcoran, Lynn M., Hardy, Richard R., Nemazee, David, Nussenzweig, Michel C., Roman, Christopher A. J., Schlissel, Mark S., Shinton, Susan A., Silver, Daniel P., Spanopoulou, Eugenia   +9 more
core  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Dupilumab Treatment Efficacy and Impact on Clinical Scores, Serum Biomarkers, and Itch in Adult Patients with Atopic Dermatitis: A Retrospective Analysis

Journal of Asthma and Allergy, 2023
Mariateresa Rossi,* Luca Bettolini,* Grazia Linda Artelli, Alessandro Fraghì, Cesare Tomasi, Piergiacomo Calzavara-Pinton Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy*These authors contributed ...
Rossi M, Bettolini L, Artelli GL, Fraghì A, Tomasi C, Calzavara-Pinton P   +5 more
doaj  

Leaf extracts of Nandina domestica Thunb ameliorate atopic dermatitis in NC/Nga mice treated with 1-chloro-2,4-dinitrobenzene (DNCB)

AIMS Bioengineering, 2021
Atopic dermatitis (AD) is a skin disease. In this study, we observed the effects of Nandina domestica (ND) on AD-induced NC/Nga mice with 1-chloro-2,4-dinitrobenzene (DNCB)-treatment.
Mi-Young Yun , Kyoung-Sook Park, Kyung-Ah Yoon, Hwa-Jung Choi   +3 more
doaj   +1 more source

Subcutaneous Immunoglobulin Replacement Therapy with Hizentra® is Safe and Effective in Children Less Than 5 Years of Age. [PDF]

, 2015
BACKGROUND:Hizentra® (IGSC 20%) is a 20% liquid IgG product approved for subcutaneous administration in adults and children 2 years of age and older who have primary immunodeficiency disease (PIDD). There is limited information about the use of IGSC 20 %
Atkinson, Thomas Prescott, Bonilla, Francisco A, Dorsey, Morna, Gallagher, Joel L, Haddad, Elie, Heimall, Jennifer, Kobrynski, Lisa, Morris, David, Ochs, Hans D, Patel, Niraj C, Wahlstrom, Justin   +10 more
core   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma

Pharmaceutical Biology, 2020
Context Airway remodelling is one of the most refractory problems in asthma. According to the critical roles of oxidative stress and inflammation in airway remodelling, it is supposed that ascorbic acid and calcitriol have beneficial effects.
Farzaneh Kianian, Seyed Morteza Karimian, Mehri Kadkhodaee, Nasrin Takzaree, Behjat Seifi, Hamid Reza Sadeghipour   +5 more
doaj   +1 more source

Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice

Marine Drugs, 2020
Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE)
Eui Jeong Han, Hyun-Soo Kim, Kalu Kapuge Asanka Sanjeewa, Kyungsook Jung, Youngheun Jee, You-Jin Jeon, Ilekuttige Priyan Shanura Fernando, Ginnae Ahn   +7 more
doaj   +1 more source

Diversity and structure of human T-Cell receptor β-chain variable region genes [PDF]

, 1986
The nucleotide sequences of 27 T-cell receptor β cDNA clones isolated from a human peripheral lymphocyte library were determined and compared to five additional published sequences. These cDNA clones represent 22 distinct T-cell receptor β-chain variable
Concannon, Patrick, Hood, Leroy, Kung, Patrick, Pickering, Lulu A.   +3 more
core  

Recurrence quantification analysis as a tool for the characterization of molecular dynamics simulations

, 1998
A molecular dynamics simulation of a Lennard-Jones fluid, and a trajectory of the B1 immunoglobulin G-binding domain of streptococcal protein G (B1-IgG) simulated in water are analyzed by recurrence quantification, which is noteworthy for its ...
A. Amadei, A. Ansari, A. E. Garcia, A. Giuliani, A. Hodel, A. R. van Buuren, A. Rahman, Alessandro Giuliani, C. E. Shannon, C. L. Webber, Jr., Cesare Manetti, Charles L. Webber, D. Mestivier, G. D. Birkhoff, G. U. Nienhaus, H. J. C. Berendsen, J. B. Clarage, J. D. Honeycutt, J. E. Straub, J. Ford, J. L. Lebowitz, J. M. Haile, J. P. Ryckaert, J. P. Zbilut, J. P. Zbilut, J. P. Zbilut, J. P. Zbilut, J. P. Zbilut, J. v. Neumann, J.-P. Eckmann, J.-P. Eckmann, Joseph P. Zbilut, L. Lligona-Trulla, L. Verlet, M. Ding, M. E. Karpen, Marc-Antoine Ceruso, N. H. Packard, P. Faure, P. J. Steinbach, P. T. Gallagher, W. F. van Gunsteren, W. F. van Gunsteren   +42 more
core   +1 more source