Results 81 to 90 of about 19,572,353 (382)
IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications [PDF]
, 2019 The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples ...
Amato, Teresa +15 more
core +2 more sources
Omalizumab, an anti-immunoglobulin E antibody: state of the art
Drug Design, Development and Therapy, 2014 A large number of trials show that the anti-immunoglobulin (Ig) E antibody omalizumab is very effective in patients with severe allergic asthma. This is acknowledged in consensus documents.
C. Incorvaia +5 more
semanticscholar +1 more source
Kimura's disease: A challenge to the cytologist
Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2021 Kimura's disease is a rare idiopathic chronic inflammatory disease which usually presents as deep-seated subcutaneous swelling in the head and neck region.
Indranil Chakrabarti
doaj +1 more source
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
core +1 more source
Immunoglobulin E plays an immunoregulatory role in lupus
Journal of Experimental Medicine, 2014 Dema et al. show evidence that deficiency of IgE delays lupuslike disease development and severity, as demonstrated by reduced autoantibody production and amelioration of organ pathologies.
B. Dema +16 more
semanticscholar +1 more source
Immunoglobulin E in erythema nodosum. [PDF]
Archives of Disease in Childhood, 1976 Twenty-two children aged from 3 years 6 months to 12 years with erythema nodosum (EN) were grouped according to aetiology into streptococcal, tuberculous, and those whose aetiology was undetermined. Serum IgE levels were determined in all by the radioimmunosorbent technique. Levels were higher (mean value 991 units/ml) in streptococcal EN than in those
S Benetos +4 more
openaire +3 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Journal of Indian Academy of Oral Medicine and RadiologyKimura disease (KD) is an uncommon, long-standing inflammatory condition affecting the head and neck that has no recognized cause. It typically appears as a painless subcutaneous nodule mimicking a tumor.
Sukanya Das +3 more
doaj +1 more source
Optimization of the treatment of patients with severe chronic urticaria
Medičnì Perspektivi, 2023 Severe chronic urticaria (SCU) is a common disease that burdens the lives of millions of people, reduces their quality of life, and imposes a significant economic burden not only on the health care system, but also directly on the patient.
Ye.M. Dytiatkovska, N.O. Nedohybchenko
doaj +1 more source
Human immunoglobulin E flexes between acutely bent and extended conformations
Nature Structural &Molecular Biology, 2014 Crystallographic and solution studies have shown that IgE molecules are acutely bent in their Fc region. Crystal structures reveal the Cɛ2 domain pair folded back onto the Cɛ3-Cɛ4 domains, but is the molecule exclusively bent or can the Cɛ2 domains adopt
N. Drinkwater +13 more
semanticscholar +1 more source