Results 1 to 10 of about 24,729 (207)
Altered IgG N-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab N-Glycans [PDF]
BiomedicinesBackground: N-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding.
Branimir Plavša +3 more
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Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution [PDF]
Proceedings of the National Academy of Sciences, 1973 The structure of the Fab′ fragment of a human myeloma immunoglobulin was determined by x-ray crystallographic analysis at 2.8-Å resolution. The Fourier map of the electron density was correlated with the aminoacid sequence to obtain a three-dimensional model. Four globular subunits, which correspond to the homology regions of the light and heavy chains,
Roberto J. Poljak +5 more
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The Three-Dimensional Structure of the Fab′ Fragment of a Human Myeloma Immunoglobulin at 2.0-Å Resolution [PDF]
Proceedings of the National Academy of Sciences, 1974 The structural analysis of the Fab′ fragment of human myeloma immunoglobulin IgGl(λ) New has been extended to a nominal resolution of 2.0 Å. Each of the structural subunits corresponding to the variable and to the constant homology regions of the light and heavy chains contains two irregular β-sheets which are roughly parallel to each other and ...
Roberto J. Poljak +4 more
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Crystallization of immunoglobulin Fab fragments specific for DNA.
Journal of Biological Chemistry, 1988 The purification and crystallization of Fab fragments of two mouse monoclonal immunoglobulins specific for different DNA structures are described. In each case, papain digestion of the immunoglobulins produced a mixture of Fab species differing in their isoelectric points.
Amechand Boodhoo +3 more
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Structure of an immunoglobulin Fab fragment specific for triple-stranded DNA. [PDF]
Journal of Biological Chemistry, 1994 Triple-stranded DNA of the form poly(Pyr).poly-(Pur).poly(Pyr) (where Pyr represents a pyrimidine, and Pur represents a purine) has become the subject of intense research because of its potential use in the control of gene expression and in the development of sequence-specific reagents for cleaving DNA.
C.D. Mol +4 more
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Allotypic Determinants on the Fab Fragment of Rabbit Aa Locus Negative IgG-Immunoglobulin [PDF]
The Journal of Immunology, 1971 Abstract Immunization of rabbits with a locus negative IgG immunoglobulin molecules obtained from an Aa2Aa2 rabbit suppressed in utero with anti-Aa2 resulted in isoantibodies directed against the a negative IgG molecules. The allotypic specificities are located on the Fab fragment of IgG and are absent on the Fc fragment. Peptide maps of
Katherine L. Knight +3 more
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Allosteric inhibition of IgE–FcεRI interactions by simultaneous targeting of IgE F(ab’)2 epitopes [PDF]
Communications BiologyImmunoglobulin E (IgE) plays pivotal roles in allergic diseases through interaction with a high-affinity receptor (FcεRI). We established that Fab fragments of anti-IgE antibodies (HMK-12 Fab) rapidly dissociate preformed IgE-FcεRI complexes in a ...
Takao Hirano +6 more
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Structure of an immunoglobulin Fab fragment specific for poly(dG).poly(dC).
Journal of Biological Chemistry, 1994 Jel 72 is a murine monoclonal antibody that is highly specific for the right-handed DNA duplex formed by poly(dG).poly(dC). The three-dimensional structure of the antigen-binding fragment (Fab) of Jel 72 has been determined by x-ray crystallographic methods and refined to 2.7-A resolution.
C.D. Mol +3 more
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Journal of Biological Chemistry, 1991 The complete amino acid sequence of the Fab fragment of protein KAU, a human monoclonal cold agglutinin (IgMk) with anti-I activity, was determined. The light chain (L-chain) consists of 215 residues; the variable (V)L region belongs to the Hum/Kv325/kIIIb sub-subgroup that is preferentially selected in human IgM autoimmune response.
Juliana Leoni +3 more
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Detection of immunoglobulin A1 protease-induced Fab alpha fragments on dental plaque bacteria [PDF]
Infection and Immunity, 1991 The mechanisms by which immunoglobulin A1 (IgA1) protease activity may enable bacteria to evade the effect of specific secretory IgA (S-IgA) antibodies are not clear. A possibility which has received indirect experimental support is that bacteria, as a consequence of the protease activity, become coated with incompetent Fab alpha fragments instead of ...
T Ahl, J Reinholdt
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