Results 101 to 110 of about 90,091 (319)

Tangent functional connectomes uncover more unique phenotypic traits [PDF]

arXiv, 2022
Functional connectomes (FCs) contain pairwise estimations of functional couplings based on pairs of brain regions activity. FCs are commonly represented as correlation matrices that are symmetric positive definite (SPD) lying on or inside the SPD manifold.
arxiv  

The structures of secretory and dimeric immunoglobulin A [PDF]

, 2020
Secretory (S) Immunoglobulin (Ig) A is the predominant mucosal antibody, which binds pathogens and commensal microbes. SIgA is a polymeric antibody, typically containing two copies of IgA that assemble with one joining-chain (JC) to form dimeric (d) IgA ...
Haloi, Nandan, Huey-Tubman, Kathryn E., Kumar Bharathkar, Sonya, Malyutin, Andrey G., Parker, Benjamin W., Stadtmueller, Beth M., Tajkhorshid, Emad   +6 more
core  

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source

CircSATB1 Promotes Colorectal Cancer Liver Metastasis through Facilitating FKBP8 Degradation via RNF25‐Mediated Ubiquitination

Advanced Science, EarlyView.
CircSATB1 is formed by the reverse splicing of exons 2–5 of the SATB1 linear transcript on chromosome 3. Mechanistically, circSATB1 facilitates the RNF25‐mediated ubiquitylation and degradation of FKBP8, releasing its inhibitory effects on mTOR signaling. In this process, circSATB1 acts as a scaffold for RNF25‐FKBP8 complexes.
Chuan Zhang, Chuanxin Tian, Renzhong Zhu, Chen Chen, Chi Jin, Xiaowei Wang, Lejia Sun, Wen Peng, Dongjian Ji, Yue Zhang, Yueming Sun   +10 more
wiley   +1 more source

Superstructures of Zeolitic Imidazolate Frameworks to Single‐ and Multiatom Sites for Electrochemical Energy Conversion

Small, Volume 18, Issue 52, December 28, 2022., 2022
This review summarizes the advances in ZIF‐derived superstructures in the electrochemical hydrogen evolution reaction, oxygen evolution reaction, and oxygen reduction reaction processes, with an emphasis on the role of metal–nitrogen–carbon active sites in catalytic properties.
Rahul Patil, Shude Liu, Anubha Yadav, Nithima Khaorapapong, Yusuke Yamauchi, Saikat Dutta   +5 more
wiley   +1 more source

Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data [PDF]

PLoS Comput Biol 15(7): e1007133 (2019), 2017
The collection of immunoglobulin genes in an individual's germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles.
arxiv   +1 more source

Structural Characterization of the Extracellular Domain of CASPR2 and Insights into Its Association with the Novel Ligand Contactin1 [PDF]

, 2015
Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including autism and language impairment.
Comoletti, Davide, Daake, Sventja von, DE JACO, Antonella, Demeler, Borries, Ellisman, Mark H., Jeffries, Cy M., Pakos, Irene S., Perkins, Guy, Ranaivoson, Fanomezana M., Rubio Marrero, Eva N., Shaikh, Tanvir R., Trewhella, Jill, Vincelli, Gabriele   +12 more
core   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu, Wei Zhang, Zhongshuai You, Guangyao Li, Chuqi Wang, Changhai Lei, Jian Zhao, Jin Hou, Shi Hu   +8 more
wiley   +1 more source

INTERACTION BETWEEN DIFFERENT MOLECULAR FORMS OF IMMUNOGLOBULIN A AND RECOMBINANT DERIVATIVES POLYPEPTIDES OF BAC RECEPTOR PROTEINS FROM GROUP B STREPTOCOCCI

Медицинская иммунология, 2014
. The article concerns interactions between immunoglobulin A and recombinant P6, P7, P8 polypeptides, designed on the basis of externally localized Bac protein of the Group B streptococci, possessing IgA-binding activity.There is a current demand for ...
A. S. Korzhueva, D. G. Ibragimova, I. A. Ustinovich, Artem A. Totolian, M. P. Samoilovich, A. N. Suvorov   +5 more
doaj   +1 more source

Regulation of elastase and plasminogen activator secretion in resident and inflammatory macrophages by receptors for the Fc domain of immunoglobulin G. [PDF]

, 1984
We have determined that the interaction of IgG-coated erythrocytes (EIgG) and complement-coated erythrocytes (EIgMC) with macrophage Fc and complement receptors, respectively, modulates the secretion of the neutral proteinases, elastase, and plasminogen ...
Takemura, R, Werb, Z
core