Frontiers in Immunology, 2017 Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke +6 more
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Chloroplast transformation for bioencapsulation and oral delivery using the immunoglobulin G fragment crystallizable (Fc) domain [PDF]
Scientific Reports, 2023 AbstractProinsulin Like Growth Factor I (prolGF-I) and myostatin (Mstn) regulate muscle regeneration and mass when intravenously delivered. We tested if chloroplast bioencapsulated forms of these proteins may serve as a non-invasive means of drug delivery through the digestive system.
Lisa M. LaManna +4 more
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Structure analysis of goose immunoglobulin Y Fc fragment [PDF]
Central European Journal of Immunology, 2013 Objective: Goose immunoglobulin Y (IgY)-Fc fragment gene is cloned. Material and methods: In order to obtain a certain length (106 bp) of constant domain gene, a pair of primer was designed according to the conserved nucleotide sequence of duck (CAA46322) and chick en (S00390) IgY-Fc fragment that was published by the GenBank.
Lei Jiang +4 more
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Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment [PDF]
Biochemical Journal, 1968 The disulphide bridges of the Fc fragment (C-terminal half of the heavy chain) have been studied in several human immunoglobulins, containing heavy chains of different antigenic types (γ1, γ2, γ3 and γ4), and in heavy-chain-disease proteins. Two intrachain disulphide bridges were found to be present.
Blas Frangione +2 more
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Customized extracellular vesicles targeting lysosomal biogenesis deliver therapeutic cargo for intervertebral disc degeneration treatment [PDF]
Journal of NanobiotechnologyExtracellular vesicles (EVs) have gained prominence as advanced drug delivery systems due to their inherent merits. Recent advancements highlight their utility in transporting therapeutic proteins with significant progress in targeted therapies.
Zhiwei Liao +4 more
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Studies on the immunoglobulin-G Fc-fragment receptor from neonatal rat small intestine [PDF]
Biochemical Journal, 1980 1. A method for preparing the small-intestinal brush-border membrane of neonatal rats is described in which enzymic methods are used to remove associated polysaccharide and cell nuclei. 2. 125I-labelled IgG (immunoglobulin G) and 125I-labelled IgG Fc fragment have high specific binding and low non-specific binding to brush borders prepared in this way.
Kristin Wallace, Anthony R. Rees
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Altered IgG N-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab N-Glycans [PDF]
BiomedicinesBackground: N-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding.
Branimir Plavša +3 more
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The interaction between protein A and immunoglobulin G as studied with the Fc‐fragment of a myeloma protein by circular dichroism [PDF]
FEBS Letters, 1975 Protein A is a cell-wall constituent from Staphylococcus UUI~W [ 1,2] with the ability to react with nonimmune immunoglobulins from several mammalia [3,4]. The active binding site for protein A is situated in the Fc-region of human IgCl, IgG2 and IgG4 [ 561. As a consequence of the reaction, the complement system, for instance, is activated, as well as
Ingvar Sjöholm
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Hierarchical Formation of Disulfide Bonds in the Immunoglobulin Fc Fragment Is Assisted by Protein-disulfide Isomerase [PDF]
Journal of Biological Chemistry, 2004 Antibodies provide an excellent system to study the folding and assembly of all beta-sheet proteins and to elucidate the hierarchy of intra/inter chain disulfide bonds formation during the folding process of multimeric and multidomain proteins. Here, the folding process of the Fc fragment of the heavy chain of the antibody MAK33 was investigated.
Floriana Vinci +6 more
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Инфекция и иммунитет, 2020 The pathogenesis of poststreptococcal glomerulonephritis (PSGN), a major complication of acute infections caused by group A streptococci (GAS) remains unclear.
L. A. Burova +3 more
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