Results 11 to 20 of about 76,339 (318)

Role of Fc fragments in inhibition of xenogenic hyperacute rejection by intravenous immunoglobulin.

Transplantation, 1996
It has been shown that a high dose administration of human intravenous immunoglobulin G (IVIG) prolonged the survival time of xenografted guinea pig heart in the rat. In this study, we compared the effectiveness of intact IVIG (I-IVIG), Fc fragments of IVIG (Fc-IVIG), and F(ab') fragments of IVIG (Fab-IVIG) in preventing xenogenic hyperacute rejection ...
T. Kojima, S. Hayashi, I. Yokoyama, H. Takagi   +3 more
semanticscholar   +3 more sources

Immuno-capture of biomolecules on functionalized magnetic beads: From characterization to fluorescent detection of a biomarker for Alzheimer's disease toward high performance biosensing

Talanta Open, 2023
It is reported herein a new approach to study the orientation and density of mouse antibody grafting on magnetic beads, serving for immunoassays and biosensors with fluorescent detection of biomolecules.
Ngoc Van Thanh Nguyen, Claire Smadja, Myriam Taverna, Trong Khoa Mai, Frédéric Halgand, Thanh Duc Mai   +5 more
doaj   +1 more source

The mosaic puzzle of the therapeutic monoclonal antibodies and antibody fragments - A modular transition from full-length immunoglobulins to antibody mimetics

Leukemia Research Reports, 2022
The use of monoclonal antibodies represents an important and efficient diagnostic and therapeutic tool in disease management and modern science but remains limited by several factors including the uneven distribution in diseased tissues as well as ...
Sami El Khatib, Mohamed Salla
doaj   +1 more source

Impact of IgG Fc-fragments on experimental glomerulonephritis induced by Streptococcus pyogenes strain binding various immunoglobulin classes

Инфекция и иммунитет, 2020
The pathogenesis of poststreptococcal glomerulonephritis (PSGN), a major complication of acute infections caused by group A streptococci (GAS) remains unclear.
L. A. Burova, P. V. Pigarevsky, V. A. Snegova, A. A. Totolian   +3 more
doaj   +1 more source

Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies

mAbs, 2023
T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells.
Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang   +8 more
doaj   +1 more source

Immunoglobulin G Fc Fragment‐Binding Proteins in Mycoplasma salivarium Cells [PDF]

Microbiology and Immunology, 1992
AbstractCell proteins of Mycoplasma salivarium were separated by sodium dodecyl sulfate‐polyacrylamide gel electrophoresis, transferred to membranes, then examined for reactivity with human IgG molecules, the Fc fragment of human IgG, and concanavalin A (ConA). Multiple protein bands bound IgG, and most of them also bound ConA.
Y, Sawa, T, Watanabe, K, Shibata
openaire   +2 more sources

Improvement of the method of obtaining human IgA Fc-fragments

Regulatory Mechanisms in Biosystems, 2015
To address a number of fundamental and applied problems in immunology, molecular and cellular biology and biotechnology it is necessary to obtain Fc-fragments of immunoglobulins.
O. Y. Galkin, Y. V. Gorshunov, V. F. Solovjova   +2 more
doaj   +1 more source

Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments.

Journal of Immunology, 1980
Adherent synovial cells (ASC) were obtained from minced synovium from patients with rheumatoid arthritis by dissociating the lining cells from the extracellular matrix and dispersing them with proteases.
J. Dayer, J. Passwell, E. Schneeberger, S. Krane   +3 more
semanticscholar   +1 more source

Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment [PDF]

Biochemical Journal, 1968
The disulphide bridges of the Fc fragment (C-terminal half of the heavy chain) have been studied in several human immunoglobulins, containing heavy chains of different antigenic types (γ1, γ2, γ3 and γ4), and in heavy-chain-disease proteins. Two intrachain disulphide bridges were found to be present.
B, Frangione, C, Milstein, E C, Franklin
openaire   +2 more sources

Activating FcγR function depends on endosomal-signaling platforms

iScience, 2023
Summary: Cell surface receptor internalization can either terminate signaling or activate alternative endosomal signaling pathways. We investigated here whether endosomal signaling is involved in the function of the human receptors for Fc immunoglobulin ...
Samira Benadda, Mathilde Nugue, Despoina Koumantou, Marcelle Bens, Mariacristina De Luca, Olivier Pellé, Renato C. Monteiro, Irini Evnouchidou, Loredana Saveanu   +8 more
doaj   +1 more source