Results 21 to 30 of about 22,044 (247)

The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement

Nature Communications, 2022
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson   +13 more
doaj   +1 more source

Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing

Scientific Reports, 2021
A major class of bispecific antibodies (BsAbs) utilizes heterodimeric Fc to produce the native immunoglobulin G (IgG) structure. Because appropriate pairing of heavy and light chains is required, the design of BsAbs produced through recombination or ...
Hiroki Akiba, Tomoko Ise, Satoshi Nagata, Haruhiko Kamada, Hiroaki Ohno, Kouhei Tsumoto   +5 more
doaj   +1 more source

Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1

Frontiers in Immunology, 2021
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM homeostasis is dysregulated. Collagen remodeling by matrix metalloproteinases
Saskia V. Vijver, Saskia V. Vijver, Akashdip Singh, Akashdip Singh, Eline T. A. M. Mommers-Elshof, Eline T. A. M. Mommers-Elshof, Jan Meeldijk, Ronald Copeland, Louis Boon, Sol Langermann, Dallas Flies, Linde Meyaard, Linde Meyaard, M. Inês Pascoal Ramos, M. Inês Pascoal Ramos   +14 more
doaj   +1 more source

The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surface. [PDF]

PLoS Pathogens, 2014
The Herpes Simplex Virus 1 (HSV-1) glycoprotein gE-gI is a transmembrane Fc receptor found on the surface of infected cells and virions that binds human immunoglobulin G (hIgG).
Blaise Ndjamen, Alexander H Farley, Terri Lee, Scott E Fraser, Pamela J Bjorkman   +4 more
doaj   +1 more source

Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies

mAbs, 2023
T-cell-engaging bispecific antibodies (T-bsAbs) are promising immunotherapies for cancer treatment due to their capability of redirecting T-cells toward destroying tumor cells.
Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu, Yuansheng Yang   +8 more
doaj   +1 more source

Improvement of the method of obtaining human IgA Fc-fragments

Regulatory Mechanisms in Biosystems, 2015
To address a number of fundamental and applied problems in immunology, molecular and cellular biology and biotechnology it is necessary to obtain Fc-fragments of immunoglobulins.
O. Y. Galkin, Y. V. Gorshunov, V. F. Solovjova   +2 more
doaj   +1 more source

Immunoglobulin Fc heterodimer platform technology: From design to applications in therapeutic antibodies and proteins

Frontiers in Immunology, 2016
The monospecific and bivalent characteristics of naturally occurring immunoglobulin G (IgG) antibodies depend on homodimerization of the fragment crystallizable (Fc) regions of two identical heavy chains (HCs) and the subsequent assembly of two identical
Ji-Hee Ha, Jung-Eun Kim, Yong-Sung Kim
doaj   +1 more source

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +1 more source

Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation

mAbs, 2022
Although several antibody fragments and antibody fragment-fusion proteins produced in Escherichia coli (E. coli) are approved as therapeutics for various human diseases, a full-length monoclonal or a bispecific antibody produced in E.
Md Harunur Rashid
doaj   +1 more source

Intracellular Antibodies for Drug Discovery and as Drugs of the Future

Antibodies, 2023
The application of antibodies in cells was first shown in the early 1990s, and subsequently, the field of intracellular antibodies has expanded to encompass antibody fragments and their use in target validation and as engineered molecules that can be ...
T. H. Rabbitts
doaj   +1 more source