Results 81 to 90 of about 22,044 (247)

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

A Novel Interaction of Staphylococcal Protein A With Human Fibronectin and Its Implications in Host Cell Adhesion. [PDF]

FASEB J
Through this study, we discovered and characterized a previously undescribed interaction between Staphylococcal protein A (SpA) and human fibronectin. We also present data that suggest a potential mechanism for SpA's contribution to bacterial adhesion to host cells, opening to potential new strategies to fight S. aureus infections.
Camaione S, Pansegrau W, Concetti F, Del Vecchio M, Dello Iacono L, Ferlenghi I, Manetti AGO, Manzi L, Norais N, Pellegrini A, Savino S, Margarit I, Pietrocola G.   +12 more
europepmc   +2 more sources

The interaction of protein A and Fc fragment of rabbit immunoglobulin G as probed by complement-fixation and nuclear-magnetic-resonance studies [PDF]

, 1977
Craig Wright, Keith J. Willan, Johan Sjödahl, Dennis R. Burton, Raymond A. Dwek   +4 more
openalex   +1 more source

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

Clinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj, Dmitry Shchelokov, Oleg Demin Jr, Homer C. Adams 3rd, Yan Feng, Leonid Gibiansky, Saskia van der Lee, Anandhi Johri, Merzu Belete, Alexander Muik, Porntula Panorchan, Özlem Türeci, Uğur Sahin, Tahamtan Ahmadi, Manish Gupta, Oleg Demin, Craig Thalhauser   +16 more
wiley   +1 more source

Progression and prognostic significance of electrocardiographic findings in patients with cardiac amyloidosis

ESC Heart Failure, Volume 12, Issue 2, Page 809-818, April 2025.
Abstract Aims This study aimed to evaluate the change of the main electrocardiographic (ECG) characteristics and their prognostic role across the main subtypes of cardiac amyloidosis [light‐chain amyloidosis (AL) and hereditary (ATTRv) and wild‐type transthyretin amyloidosis (ATTRwt)].
Alessia Argirò, Mattia Zampieri, Carlotta Mazzoni, Carlo Fumagalli, Michela Baccini, Alessandra Mattei, Alberto Cipriani, Laura De Michieli, Aldostefano Porcari, Gianfranco Sinagra, Marco Merlo, Giacomo Tini, Beatrice Musumeci, Domitilla Russo, Pier Filippo Vianello, Marco Canepa, Roberto Licordari, Gianluca di Bella, Claudio Rapezzi, Federico Perfetto, Francesco Cappelli   +20 more
wiley   +1 more source

Staphylococci-induced Human Platelet Injury Mediated by Protein A and Immunoglobulin G Fc Fragment Receptor [PDF]

, 1979
Jack Hawiger, S. Steckley, Dianne Hammond, C. Cheng, Sheila Timmons, Alan D. Glick, Roger M. Des Prez   +6 more
openalex   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

Electrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Interactions among rheumatoid synovial cells and monocyte-macrophages: production of collagenase-stimulating factor by human monocytes exposed to concanavalin A or immunoglobulin Fc fragments. [PDF]

, 1980
J.-M. Dayer, J H Passwell, Eveline E. Schneeberger, Stephen M. Krane   +3 more
openalex   +1 more source

Assessing Thermal Maturity of the Pendência Formation (Potiguar Basin) Using Vitrinite Reflectance and Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Palynofacies assemblages from the onshore Potiguar Basin display a wide thermal maturity range, with vitrinite reflectance (%Ro) values of 0.46–2.72 measured from nine samples at depths of 1059–4443 m. A strong correlation exists between %Ro and Raman parameters, specifically the G‐band's full width at half maximum.
Gabriel A. Barberes, Dalva A. L. Almeida, Flávia C. Marques, Julliana F. Alves, Paulo H. M. Toledo, Rafael de Oliveira, Lenize F. Maia, Linus Pauling F. Peixoto, Antonio Carlos Sant'Ana, Celly M. S. Izumi, Gustavo F. S. Andrade, Dorval C. Dias Filho, Taissa R. Menezes, Delano M. Ibanez, Luiz Fernando C. de Oliveira   +14 more
wiley   +1 more source

Evidence for a Modulatory Effect of a 12‐Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof‐of‐Principle Study

Molecular Nutrition &Food Research, EarlyView.
This study investigated how pomegranate juice affects inflammation in patients with inflammatory bowel disease who are currently in remission. After 12 weeks of drinking pomegranate juice, patients showed reduced markers of intestinal inflammation.
Ilaria Minato, Pedro Mena, Luigi Ricciardiello, Eleonora Scaioli, Andrea Belluzzi, Enrica Rotondo, Eleonora Derlindati, Barbara Montanini, Costanza Michelini, Nicole Tosi, Vicente Agullò Garcià, Gianfranco Picone, Carlo Mengucci, Sara Dobani, Paloma Salamanca, Alice Rosi, Margherita Dall'Asta, Letizia Bresciani, Claudio Curti, Enzo Spisni, Alessandra Dei Cas, Alessandra Bordoni, Francisco A. Tomás‐Barberán, Lynnette R. Ferguson, Daniele Del Rio, Francesca Danesi   +25 more
wiley   +1 more source