Results 141 to 150 of about 116,527 (269)

Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia

BioEssays, EarlyView.
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley   +1 more source

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source

Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. [PDF]

, 1979
Darrell J. Kemp, Suzanne Cory, Jerry M. Adams   +2 more
openalex   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Data on the nucleotide composition of the first codons encoding the complementary determining region 3 (CDR3) in immunoglobulin heavy chains

Data in Brief, 2018
The highly variable complementary determining region 3 (CDR3) of antibodies is generated through recombination of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes.
Linnea Thörnqvist, Mats Ohlin
doaj  

Implications of Heavy Chain Disease Protein Sequences for Multiple Gene Theories of Immunoglobulin Synthesis [PDF]

, 1970
William D. Terry, JACK J. OHMS
openalex   +1 more source

Sequence of Amino Acids of the NH₂‐Terminal Region of a Mouse‐Clonal Immunoglobulin Heavy Chain [PDF]

, 1972
Alain Bourgois, Michel Fougereua, C. de Préval   +2 more
openalex   +1 more source

Isolation of mRNA coding for immunoglobulin heavy chain [PDF]

Proceedings of the National Academy of Sciences, 1975
A. R. Williamson, Ronald H. Stevens
openaire   +3 more sources

Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies

Chemistry &Biodiversity, EarlyView.
Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang, Huiling Liu, Bingdong Zhu, Wen Li, Xue Han, Jiaojiao Fu, Renjie Luo, Haiyan Wang, Jinxia Wang   +8 more
wiley   +1 more source

A case of heavy-chain deposition disease with good long-term renal survival and a literature review

BMC Nephrology
Background Monoclonal immunoglobulin deposition disease (MIDD) is characterized by the deposition of nonamyloid monoclonal immunoglobulin and its free fragment light chain and/or heavy chain in systemic tissues and organs, and the kidney is most ...
Xiaoqing Cai, Wenli Zou, Huaihuai Chen, Chaonian Xing, Xuguang Yu   +4 more
doaj   +1 more source