Results 141 to 150 of about 235,597 (396)
Biosynthetic units of an immunoglobulin heavy chain. [PDF]
Proceedings of the National Academy of Sciences, 1967 Knopf, P M, Parkhouse, R M, Lennox, E S
openaire +3 more sources
Annals of Neurology, EarlyView.Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke +36 more
wiley +1 more source
EVIDENCE FOR MULTIPLE GENE CONTROL OF A SINGLE POLYPEPTIDE CHAIN: THE HEAVY CHAIN OF RABBIT IMMUNOGLOBULIN [PDF]
, 1969 Marian Elliott Koshland +2 more
openalex +1 more source
Quantifying evolutionary constraints on B cell affinity maturation
, 2014 The antibody repertoire of each individual is continuously updated by the evolutionary process of B cell receptor mutation and selection. It has recently become possible to gain detailed information concerning this process through high-throughput ...
Bedford, Trevor +5 more
core +2 more sources
Biallelic Variants in the DARS2 Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease
Annals of Neurology, EarlyView.Objective Charcot–Marie–Tooth (CMT) disease is a heterogeneous group of genetic neuropathies, with >90 genes identified. Several aminoacyl‐tRNA synthetases have been linked to CMT. DARS2, encoding the mitochondrial aspartyl‐tRNA synthetase, has been typically associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate ...
Berta Estévez‐Arias +23 more
wiley +1 more source
The Amino Acid Sequence of the N-Terminal 84 Residues of a Human Heavy Chain of Immunoglobulin G (Daw) [PDF]
, 1967 E. M. Press
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Annals of Neurology, EarlyView.Objective The growing demand for personalized treatment in multiple sclerosis (MS) highlights the need for more precise biomarkers that can outperform magnetic resonance imaging and clinical assessment in patient stratification. Advances in multiplex proteomic technologies suggest that cerebrospinal fluid (CSF) analysis at MS onset may not only improve
Laura Ghezzi +10 more
wiley +1 more source
The structure of the heavy chain of immunoglobulin and its relevance to the nature of the antibody-combining site. The Second CIBA Medal Lecture [PDF]
, 1967 Roy Porter
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The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene [PDF]
, 1982 We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology
Berson, Bennett J. +2 more
core
Advanced NanoBiomed Research, EarlyView.Perfluorocarbon‐based artificial oxygen carriers have long been of scientific interest for because they can be used as oxygen donors in medical applications. Lecithin‐modified nanoscale oxygen carriers (LENOX) are a newly designed nanoscaled emulsion based on perfluorodecalin, which is characterized by its compatibility with numerous clinically ...
Fabian Nocke +5 more
wiley +1 more source