Results 171 to 180 of about 225,064 (376)

Immunoglobulin Heavy Chain Deletion

Definitions, 2020

semanticscholar   +1 more source

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Plasma transferrin (Tf) is the transport protein central to the process of iron recycling and metabolism. Holo‐Tf serves as the body's pool of ferric iron, facilitating transport from tissues such as the intestine, liver, spleen, and finally bone marrow, where iron is incorporated into erythropoiesis.
Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O'Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +9 more
wiley   +1 more source

A case of amyloid goitre in heavy chain amyloidosis: diagnostic challenges and clinical implications

European Journal of Case Reports in Internal Medicine
Immunoglobulin heavy chain amyloidosis (AH amyloidosis) is an extremely rare subtype of immunoglobulin-derived amyloidosis and there is limited literature on how to diagnose and manage this disorder. We describe a rare case of AH amyloidosis with amyloid
Francisco Laranjeira, Bernardo Neves, Paulo Bernardo, Francisco do Rosário, Otília Fernandes, Evelina Mendonça, Ana Catarino   +6 more
doaj   +1 more source

From IgZ to IgT: A Call for a Common Nomenclature for Immunoglobulin Heavy Chain Genes of Ray-Finned Fish. [PDF]

Zebrafish, 2021
Dornburg A, Ota T, Criscitiello MF, Salinas I, Sunyer JO, Magadán S, Boudinot P, Xu Z, Flajnik MF, Singer A, Gambón-Deza F, Hansen JD, Yoder JA.   +12 more
europepmc   +1 more source

Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]

, 2009
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core   +1 more source

Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype. [PDF]

, 1975
Jean‐Louis Preud'homme, Barbara K. Birshtein, Matthew D. Scharff   +2 more
openalex   +1 more source

A Surface Plasmon Resonance‐Based Integrated Assay for Quantification and Glycosylation Characterization of Monoclonal Antibodies in Crude Heterogeneous Samples

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer, Catherine Forest‐Nault, Julie Guimond, Simon Joubert, Olivier Henry, Yves Durocher, Gregory De Crescenzo, Jimmy Gaudreault   +7 more
wiley   +1 more source

Next-Generation-Sequencing of the Human B-Cell Receptor Improves Detection and Diagnosis and Enhances Disease Monitoring in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Journal of Molecular Pathology
Mucosa-associated lymphoid tissue (MALT) lymphomas are slow-growing B-cell lymphomas mainly diagnosed in the stomach and termed gastric MALT lymphoma (G-MALT).
Chidimma Agatha Akpa, Cora Husemann, Chris Allen, Ann-Christin von Brünneck, Jana Ihlow, Michael Hummel   +5 more
doaj   +1 more source

Implications of Heavy Chain Disease Protein Sequences for Multiple Gene Theories of Immunoglobulin Synthesis [PDF]

, 1970
William D. Terry, JACK J. OHMS
openalex   +1 more source

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source