Results 321 to 330 of about 225,064 (376)

A Single‐Center Retrospective Study of the Investigation of Monoclonal B‐Cell Lymphocytosis (MBL) and Chronic Lymphocytic Leukemia (CLL) in Southwestern Ontario: Are We Over‐Investigating?

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Monoclonal B‐cell lymphocytosis (MBL) is a common cause of lymphocytosis in older individuals. Although cytogenetic/molecular testing is usually reserved for patients requiring treatment, recent studies suggest that early testing may have a prognostic benefit in MBL and early‐stage chronic lymphocytic leukemia (CLL).
Ortenc Hoxha, Mrinal Lad, Benjamin D. Hedley, Ian H. Chin‐Yee, Cyrus C. Hsia, Benjamin Chin‐Yee   +5 more
wiley   +1 more source

Elementary immunology [PDF]

, 2017
Gogolák, Péter, Koncz, Gábor
core  

Outcomes of allogeneic haemopoietic transplant for chronic lymphocytic leukaemia in the modern era

Internal Medicine Journal, EarlyView.
Abstract Background Allogeneic haemopoietic stem cell transplantation (HSCT) is an effective therapy with curative potential for patients with high‐risk or relapsed/refractory chronic lymphocytic leukaemia (CLL). There are limited data on the use and outcomes of HSCT in the modern era of CLL treatment.
Luani Barge, Steven Tran, Glen Kennedy, David Ritchie, David Gottlieb, Sam Milliken, Andrew Spencer, Duncan Purtill, Travis Perera, Richard Doocey, Stephen Larsen, Andrew Butler, Peter Bardy, Matthew Greenwood, Simon Durrant, Cameron Curley, Caroline Stewart, Constantine Tam, Shalini Balendran, Pietro R. Di Ciaccio, Sushrut Patil, Min‐Hi Han, Nada Hamad   +22 more
wiley   +1 more source

Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity?

Immunology, EarlyView.
Immunoglobulin E has been extensively studied in allergies and parasitic diseases. Antigen‐specific IgE has been identified as part of the humoral response to viruses. This revision speculates on possible functionalities for IgE, such as neutralisation, cytotoxicity and immunopathology of viral diseases, and provide insights about gaps to fill in ...
Amanda Izeli Portilho, Valéria Oliveira Silva, Luis Fernando de Macedo Brigido, Elizabeth De Gaspari   +3 more
wiley   +1 more source

METTL3/YTHDF3 m6A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1

Journal of Diabetes Investigation, EarlyView.
METTL3/YTHDF3 m6A axis promoted ferroptosis in DKD by stabilizing TfR1, which could provide a reference for DKD treatment. ABSTRACT Objective Diabetic kidney disease (DKD) is a common complication of diabetes. N6‐Methyladenosine (m6A) modification is a widely studied epigenetic mechanism.
Jinmei Zhang, Xiaoping Zhou, Bin Wang, Yan Yin, Daihao Wei, Kun Li   +5 more
wiley   +1 more source

Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol

Journal of Neuroendocrinology, EarlyView.
Abstract Evidence from both clinical and preclinical studies indicates that females experience a faster progression to drug addiction and more severe addiction‐related health effects compared with males. Estradiol (E2) plays a critical role in these sex differences.
Patricia Sinclair, Navdeep S. Dhanjal, E. Blair Towers, Wendy J. Lynch, Nadine Kabbani   +4 more
wiley   +1 more source

Germ-line genetic variation in the immunoglobulin heavy chain creates stroke susceptibility in the spontaneously hypertensive rat.

Physiol Genomics, 2019
Dhande IS, Kneedler SC, Joshi AS, Zhu Y, Hicks MJ, Wenderfer SE, Braun MC, Doris PA.   +7 more
europepmc   +1 more source

Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology

Annals of the New York Academy of Sciences, EarlyView.
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker, Amanda Vicente‐Santos, Ashley B. Reers, B. R. Ansil, Mika O'Shea, Caroline A. Cummings, Alicia J. Roistacher, Rita M. Quintela‐Tizon, Manuela M. T. Pereira, Juniper Rosen, Arinjay Banerjee, Hannah K. Frank   +11 more
wiley   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, EarlyView.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source

JMJ720 regulates flowering time in rice via H3K9 demethylation of Hd1

Plant Biotechnology Journal, EarlyView.
Summary Heading date is a crucial agronomic trait that determines the adaptability of rice to specific planting regions and seasons. Although numerous heading date genes have been well characterized in rice, epigenetic regulation of flowering time remains limited.
Xiufeng Li, Jiaping Zhu, Xiaojie Tian, Yingxiang Liu, Jiaming Wei, Zhipeng Hong, Xin Jin, Chunxiao Chen, Zhenyu Wang, Jiaqi Tang, Xianwei Song, Qingyun Bu   +11 more
wiley   +1 more source