Results 321 to 330 of about 235,597 (396)

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

Generation and plant production of recombinant fluorescent immunoglobulin G as innovative immunodiagnostic reagents

Plant Biotechnology Journal, EarlyView.
Summary Immunodiagnostic systems for on‐site screening are increasingly in demand but require expensive reagents such as chemically modified antibodies. To obtain biomolecules as ready‐to‐use reagents for diagnostics, new recombinant fluorescent immunoglobulins G were generated by fusion of the heavy chain of a monoclonal antibody, 5H3, to two ...
Ramona Sterpa, Marcello Catellani, Patrizia Melpignano, Thea Serra, Laura Anfossi, Cristina Capodicasa   +5 more
wiley   +1 more source

Structural Design and Immunogenicity of a Novel Self‐Adjuvanting Mucosal Vaccine Candidate for SARS‐CoV‐2 Expressed in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Mucosal vaccination for COVID‐19 to boost preexisting though insufficient systemic and local/mucosal immunity remains an attractive prospect but there are currently no licensed mucosal vaccines against this infection. Here, using a plant expression system, we developed a novel mucosal vaccine platform for respiratory viruses and demonstrated ...
Mi‐Young Kim, Andy Cano Tran, Ju Kim, Humblenoble Stembridge Ayuk, Adam Sparrow, Lorenzo Bossi, Megan Brown, Emil Joseph Vergara, Kathrin Göritzer, Elisabetta Groppelli, Tae‐Ho Kwon, Julian K. C. Ma, Yong‐Suk Jang, Rajko Reljic   +13 more
wiley   +1 more source

CRISPR/Cas9‐Mediated Knockouts of the ALG3 and GNTI in N. benthamiana and Their Application to Pharmaceutical Production

Plant Biotechnology Journal, EarlyView.
ABSTRACT N‐Glycosylation critically influences the efficacy, safety and pharmacokinetic properties of biopharmaceuticals. Plant expression platforms offer multiple advantages for the production of N‐glycosylated proteins, but their use is impeded by the presence of plant‐specific N‐glycan epitopes, which raise concerns of possible immunogenicity to ...
Dolgormaa Bataa, Hiroyuki Kajiura, Reimi Lai Sang Sawada‐Choi, Yukino Yamashita, Takeshi Ishimizu, Ryo Misaki, Atsushi Takeda, Kazuhito Fujiyama   +7 more
wiley   +1 more source

Skill‐Biased Policy Change: Governing the Transition to the Knowledge Economy in Germany, Sweden and Britain

Regulation &Governance, EarlyView.
ABSTRACT How have advanced capitalist democracies transitioned from a Fordist to a post‐Fordist, knowledge‐based economy? And why have they followed seemingly similar policy trajectories despite different economic models and sectoral specializations? We develop the notion of skill‐biased policy change to answer these questions. Drawing on a distinction
Sebastian Diessner, Niccolo Durazzi, Federico Filetti, David Hope, Hanna Kleider, Simone Tonelli   +5 more
wiley   +1 more source

Germ-line genetic variation in the immunoglobulin heavy chain creates stroke susceptibility in the spontaneously hypertensive rat.

Physiol Genomics, 2019
Dhande IS, Kneedler SC, Joshi AS, Zhu Y, Hicks MJ, Wenderfer SE, Braun MC, Doris PA.   +7 more
europepmc   +1 more source

‘I'm Dead!’: Action, Homicide and Denied Catharsis in Early Modern Spanish Drama

Renaissance Studies, EarlyView.
Abstract In early modern Spanish drama, the expression ‘¡Muerto soy!’ (‘I'm dead!’) is commonly used to indicate a literal death or to figuratively express a character's extreme fear or passion. Recent studies, even one collection published under the title of ‘¡Muerto soy!’, have paid scant attention to the phrase in context, a serious omission when ...
Ted Bergman
wiley   +1 more source

A Molecular Basis for Antibody Specificity Crystal Structures of IgE-Allergen and IgG-Hapten Complexes [PDF]

Niemi, Merja
core  

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Immunoglobulin heavy chain binding protein

Nature, 1983
Pre-B lymphocytes, and hybridomas derived from them, synthesize immunoglobulin heavy (IgH) chain in the absence of light (L) chain. In the Abelson virus transformed line 18-81, which is representative of the pre-B cell stage, we observed that at least some of the H-chains are bound to a protein other than L-chain.
I. Haas, M. Wabl
semanticscholar   +4 more sources

Immunoglobulin light chain amyloidosis: 2024 update on diagnosis, prognosis, and treatment

American journal of hematology/oncology, 2023
Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues.
M. Gertz
semanticscholar   +1 more source