Results 141 to 150 of about 64,384 (337)

Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: implications for B-cell selection

, 2018
Autoreactive B cells have a central role in the pathogenesis of rheumatoid arthritis (RA), and recent findings have proposed that anti-citrullinated protein autoantibodies (ACPA) may be directly pathogenic.
Amara, Khaled, Baeten, Dominique, Gabay, Cem, Gronwall, Caroline, Israelsson, Lena, Klareskog, Lars, Lanzavecchia, Antonio, Lloyd, Katy A., Lundberg, Karin, Lundstrom, Susanna L., Malmstrom, Vivianne, Mueller, Daniel L., Piccoli, Luca, Reed, Evan, Steen, Johanna, Titcombe, Philip J., Zhou, Diana, Zubarev, Roman A.   +17 more
core   +1 more source

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide‐Cyclisation‐Bioconjugation

Angewandte Chemie International Edition, Accepted Article.
Achieving modular, selective and homogeneous protein modifications is of utmost importance for the design of next generation biopharmaceuticals; especially in the context of antibody‐drug conjugates (ADCs). Here, we introduce unsaturated phosphine oxides as versatile triple‐reactive reagents, allowing orthogonal chemoselective bioconjugation schemes ...
Christian E. Stieger, Alastair McMillan, Mark A. R. de Geus, Jan Vincent Arafiles, Luise Franz, Christian Hackenberger   +5 more
wiley   +1 more source

Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Animal Research and One Health, EarlyView.
Therapeutic effect of natural products on chicken coccidiosis. Abstract The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment.
Pan Chen, Kaili Liu, Taojing Yue, Yanan Lu, Senyang Li, Fuchun Jian, Shucheng Huang   +6 more
wiley   +1 more source

Evidence for somatic selection of natural autoantibodies. [PDF]

, 1992
Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a variety of self-antigens, including self-IgG. Accounting for a large proportion of the early B cell repertoire, such polyspecific autoantibodies are speculated to ...
Carson, DA, Duffy, SF, Kipps, TJ, Martin, T   +3 more
core  

Incidence of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis Treated With JAK Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs: Data From an International Collaboration of Registries

Arthritis &Rheumatology, EarlyView.
Objective Our objective was to assess the incidence of major adverse cardiovascular events (MACEs) in patients with rheumatoid arthritis (RA) treated with JAK inhibitors (JAKi), tumor necrosis factor inhibitors (TNFi), or biologic disease‐modifying antirheumatic drugs with other modes of action (bDMARD‐OMA) in a multicountry, real‐world population ...
Romain Aymon, Denis Mongin, Romain Guemara, Zubeyir Salis, Johan Askling, Denis Choquette, Catalin Codreanu, Daniela Di Giuseppe, Irini Flouri, Doreen Huschek, Kimme L. Hyrich, Florenzo Iannone, Tore K. Kvien, Burkhard F. Leeb, Dan Nordström, Lucia Otero‐Varela, Karel Pavelka, Manuel Pombo‐Suarez, Ana Rodrigues, Ziga Rotar, Prodromos Sidiropoulos, Sella A. Provan, Anja Strangfeld, Trokovic Nina, Jakub Zavada, Lianne Kearsley‐Fleet, Delphine S. Courvoisier, Axel Finckh, Kim Lauper   +28 more
wiley   +1 more source

PURIFICATION AND PARTIAL CHARACTERIZATION OF SERUM IMMUNOGLOBULIN FROM PERSIAN STURGEON (ACIPENSER PERSICUS)

‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2003
In this study, immunoglobulins from serum of Persian sturgeon (Acipenser persicus) were purified and partially characterized. Immunoglobulins were purified from the pooled sera by a combination of salt precipitation, Ion-exchange chromatography and gel ...
M. Kalbasi1; A. Mostafaei2; J. Majidi3
doaj  

Case report: ‘Atypical Richter transformation from CLL-type monoclonal B-cell lymphocytosis into Burkitt lymphoma in a treatment naïve patient’

Frontiers in Oncology
BackgroundRichter transformation refers to the progression of an initially slow-growing small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) into an aggressive lymphoma, typically diffuse large B-cell lymphoma (DLBCL) or Hodgkin lymphoma ...
Annaïse J. Jauch, Ilaria Alborelli, Andreas Reusser, Albert Baschong, Cyrill Rütsche, Olivier Bignucolo, Jakob Passweg, Stefan Dirnhofer, Fatime Krasniqi   +8 more
doaj   +1 more source

Organization of immunoglobulin heavy chain genes and allelic deletion model. [PDF]

, 1978
Tasuku Honjo, Tohru Kataoka
openalex   +1 more source

The Immune System [PDF]

, 1995
Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut, McCarthy, Donna O.   +1 more
core   +1 more source

Transferrin Purification, Biophysical Characterization, and Lung Biodistribution in Sickle Cell Disease Mice

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Plasma transferrin (Tf) is the transport protein central to the process of iron recycling and metabolism. Holo‐Tf serves as the body's pool of ferric iron, facilitating transport from tissues such as the intestine, liver, spleen, and finally bone marrow, where iron is incorporated into erythropoiesis.
Shuwei Lu, Mohd A. Khan, Saini Setua, Quintin O'Boyle, Kiruphagaran Thangaraju, Pedro Cabrales, Delaney C. Swindle, David C. Irwin, Paul W. Buehler, Andre F. Palmer   +9 more
wiley   +1 more source