Results 141 to 150 of about 167,223 (374)
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam+10 more
wiley +1 more source
Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish
Summary: B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a variable (V) region mediating antigen ...
Pedro Perdiguero+3 more
doaj
Wearable Bioelectronics for Home‐Based Monitoring and Treatment of Muscle Atrophy
As an inevitable disease, muscle atrophy has received more attention. Because the factors that induce this disease are diverse, achieving a complete cure is still impossible. Wearable bioelectronics provides a more comfortable, low‐cost, and efficient way of home care for the monitoring and treatment of muscle atrophy. Therefore, this review summarizes
Shuai Zhang+4 more
wiley +1 more source
Intrachain disulphide bridges in immunoglobulin G heavy chains. The Fc fragment.
The disulphide bridges of the Fc fragment (C-terminal half of the heavy chain) have been studied in several human immunoglobulins, containing heavy chains of different antigenic types (gamma1, gamma2, gamma3 and gamma4), and in heavy-chain-disease ...
B. Frangione, C. Milstein, E. Franklin
semanticscholar +1 more source
This study extensively characterizes the B cell response of rainbow trout (Oncorhynchus mykiss) in response to red mark syndrome (RMS). This disease, suspected to be caused by a Midichloria‐like organism (MLO), induces skin lesions in the infected animals, characterized by a massive influx of IgM+ B cells.
J Germán Herranz‐Jusdado+10 more
wiley +1 more source
AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering
AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun+13 more
wiley +1 more source
In-Cell Assembly of scFv from Human Thyroid- Infiltrating B Cells
The construction of a large library of single-chain Fv (scFv) antibody fragments involves a random assortment of heavy and light chains. Although useful for the production of recombinant antibodies, this method is not adapted to the study of the ...
N. Chapal+6 more
doaj +1 more source
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu+15 more
wiley +1 more source
The partial sequence of two large peptides from the N-terminal half of heavy chains from normal rabbit immunoglobulin G [PDF]
John J. Cebra+2 more
openalex +1 more source
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang+12 more
wiley +1 more source