Results 11 to 20 of about 64,384 (337)

A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class

open access: yesJournal of Microbiology & Biology Education, 2023
This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene ...
Kelly N. Hallstrom, Gwendowlyn S. Knapp
doaj   +1 more source

Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.

open access: yesPLoS Computational Biology, 2022
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo   +3 more
doaj   +1 more source

Immunoglobulin heavy-chain-associated amyloidosis. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1990
Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtained from a patient who had extensive
Alan Solomon   +2 more
openaire   +3 more sources

Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma

open access: yesDiagnostic Pathology, 2022
Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda   +9 more
doaj   +1 more source

Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]

open access: yesPLoS ONE, 2018
Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs   +11 more
doaj   +1 more source

Immunoglobulin Heavy Chain Exclusion in the Shark

open access: yesPLoS Biology, 2008
The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Wendy Feng   +6 more
openaire   +5 more sources

Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case

open access: yesSaudi Journal of Kidney Diseases and Transplantation, 2021
The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari   +5 more
doaj   +1 more source

Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease protein [PDF]

open access: yes, 1995
Background: Heavy-chain diseases (HCDs) are human lymphoproliferative neoplasias that are characterized by the secretion of truncated immunoglobulin heavy chains devoid of light chains.
Bucchini, Danielle   +6 more
core   +1 more source

Distribution of immunoglobulin heavy chains in diseased synovia. [PDF]

open access: yesJournal of Clinical Pathology, 1986
Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting
Freemont, AJ, Rutley, C.
openaire   +4 more sources

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