Results 11 to 20 of about 62,032 (209)
Mediterranean Journal of Hematology and Infectious Diseases, 2023 Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna +5 more
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A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class
Journal of Microbiology & Biology Education, 2023 This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene ...
Kelly N. Hallstrom, Gwendowlyn S. Knapp
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PLoS Computational Biology, 2022 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo +3 more
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Diagnostic Pathology, 2022 Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda +9 more
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Immunoglobulin heavy-chain-associated amyloidosis. [PDF]
Proceedings of the National Academy of Sciences, 1990 Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtained from a patient who had extensive
M, Eulitz, D T, Weiss, A, Solomon
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Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]
PLoS ONE, 2018 Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs +11 more
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Structure-function relations in phosphorylcholine-binding mouse myeloma proteins [PDF]
, 1977 The binding site interactions between the phosphorylcholine (phosphocholine)-binding mouse myeloma proteins TEPC 15, W3207, McPC 603, MOPC 167, and MOPC 511 and the isotopically substituted hapten phosphoryl-[methyl-13C]choline have been investigated ...
Goetze, Andrew M., Richards, John H.
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Human Immunoglobulin Heavy Chain Genes
Journal of Biological Chemistry, 1989 genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
J D, Capra, P W, Tucker
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The Immunoglobulins of Cold-Blooded Vertebrates [PDF]
, 2014 Peer reviewedPublisher ...
Chen +22 more
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Characterization of immunoglobulin heavy chain knockout rats [PDF]
European Journal of Immunology, 2010 AbstractThe rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene‐specific mutations. In a recent study, we described for the first time the generation of novel rat lines with targeted mutations using zinc‐finger nucleases.
Séverine, Ménoret +9 more
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