Results 11 to 20 of about 167,223 (374)

Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]

open access: yesPeerJ, 2023
The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova   +4 more
doaj   +2 more sources

Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]

open access: yesPLoS ONE, 2014
Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita   +7 more
doaj   +1 more source

Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?

open access: yesAntibodies, 2022
When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong   +4 more
doaj   +1 more source

Immunoglobulin heavy chain gene rearrangement in heavy chain deposition disease suggests it is a plasma cell disease: a case report

open access: yesJournal of International Medical Research, 2022
Heavy chain deposition disease (HCDD) is characterized by the deposition of truncated monoclonal immunoglobulin heavy chains along glomerular basement membranes.
Qingqing Rao, Ricong Xu, Qijun Wan
doaj   +1 more source

Human Gm, Km, and Am Allotypes: WHO/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies

open access: yesBioMedInformatics, 2023
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

The Leukocyte Immunoglobulin-Like Receptor Family Member LILRB5 Binds to HLA-Class I Heavy Chains. [PDF]

open access: yesPLoS ONE, 2015
The leukocyte immunoglobulin-like receptor (LILR) family includes inhibitory and stimulatory members which bind to classical and non-classical HLA-class I.
Zhiyong Zhang   +6 more
doaj   +1 more source

Gamma heavy chain disease associated with T-cell large granular lymphocyte lymphoproliferative disorder: case report and literature review.

open access: yesMediterranean Journal of Hematology and Infectious Diseases, 2023
Heavy chain diseases are rare B-cell neoplasms consisting of the production of a monoclonal immunoglobulin composed of the only heavy chain without corresponding light chains.
Maria Laura Bisegna   +5 more
doaj   +1 more source

A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class

open access: yesJournal of Microbiology & Biology Education, 2023
This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene ...
Kelly N. Hallstrom, Gwendowlyn S. Knapp
doaj   +1 more source

Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.

open access: yesPLoS Computational Biology, 2022
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo   +3 more
doaj   +1 more source

Immunoglobulin heavy-chain-associated amyloidosis. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1990
Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtained from a patient who had extensive
Alan Solomon   +2 more
openaire   +3 more sources

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