Results 11 to 20 of about 64,384 (337)
Heavy and light chains of a homogeneous immunoglobulin‐G [PDF]
Zuhayr L. Awdeh+2 more
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A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class
This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene ...
Kelly N. Hallstrom, Gwendowlyn S. Knapp
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Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo+3 more
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Immunoglobulin heavy-chain-associated amyloidosis. [PDF]
Immunoglobulin- or multiple myeloma-associated amyloidosis has been distinguished by the tissue deposition of Congophilic, fibrillar protein consisting of light chains or light-chain fragments (AL amyloidosis). We now report the isolation and characterization of another form of immunoglobulin-associated amyloid obtained from a patient who had extensive
Alan Solomon+2 more
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Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda+9 more
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Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]
Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs+11 more
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Immunoglobulin Heavy Chain Exclusion in the Shark
The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Wendy Feng+6 more
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Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case
The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari+5 more
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Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease protein [PDF]
Background: Heavy-chain diseases (HCDs) are human lymphoproliferative neoplasias that are characterized by the secretion of truncated immunoglobulin heavy chains devoid of light chains.
Bucchini, Danielle+6 more
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Distribution of immunoglobulin heavy chains in diseased synovia. [PDF]
Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains. A high proportion of plasma cells in the superficial subintima in all diseases reacted for alpha heavy chains. Only in rheumatoid disease did the synovium contain more than 10% of plasma cells reacting
Freemont, AJ, Rutley, C.
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