Results 111 to 120 of about 34,792 (276)

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials [PDF]

, 2018
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety ...
Atkinson, John P, Boyer, Ryan, Gu, Zhonghu, Gupta, Soumi, Harding, Cary O, Knight, Vijaya, Larimore, Kevin, Lau, Kelly, Li, Mingjin, Olbertz, Joy, Rosen, Orli, Shepherd, Gillian, Shweighardt, Becky, Weng, Haoling H, Zoog, Stephen J   +14 more
core   +2 more sources

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Systemic and local antibodies induced by an experimental inactivated vaccine against bovine herpesvirus type 1 Anticorpos locais e sistêmicos induzidos por uma vacina experimental inativada contra o herpesvírus bovino tipo 1

Ciência Rural, 2011
An experimental inactivated vaccine against bovine herpesvirus-1 (BoHV-1) was produced aiming to evaluate the systemic and local antibody responses in 12 seronegative heifers, after vaccination and revaccination.
Maria do Carmo Cilento, Edviges Maristela Pituco, Ricardo Spacagna Jordão, Cláudia Pestana Ribeiro, Moacir Marchiori Filho, Hélio José Montassier   +5 more
doaj   +1 more source

The Interaction of Phospholipase C-{beta}3 with Shank2 Regulates mGluR-mediated Calcium Signal [PDF]

, 2005
Phospholipase C-{beta} isozymes that are activated by G protein-coupled receptors (GPCR) and heterotrimeric G proteins carry a PSD-95/Dlg/ZO-1 (PDZ) domain binding motif at their C terminus. Through interactions with PDZ domains, this motif may endow the
Hwang, Jong-Ik, Kim, Eunjoon, Kim, Hyeon Soo, Lee, Jae Ran, Ryu, Sung Ho, Suh, Pann-Ghil   +5 more
core  

Immunodepletion in xenotransplantation [PDF]

, 1990
Xenograft transplantation is perhaps the most immunologically difficult problem in transplantation today. An overwhelming hyperacute rejection reaction (HAR) occurs within minutes of organ implantation.
A. Casavilla, A. G. Tzakis, A. Oks, A. Oral, B. Banner, Branda R F, Forsgren A, Giles G R, J. Murray, K. Yanaga, L. Makowka, L. Podesta, Langone J J, P. D'andrea, R. Shapiro, R. Watt, S. Wos, T. E. Starzl, Ting A, V. Scantlebury   +19 more
core   +1 more source

Construction of a clickable probe‐based protein chip platform for discovering covalent mIDH1 inhibitors from natural medicinal extracts

iMeta, EarlyView.
In this study, we develop a flexible Ccc‐Chip (protein microarray + bioorthogonal click chemistry) for high‐throughput screening of natural covalent active molecules from medicinal plant extracts, identifying flavokawain C from Piper methysticum Forst as a novel covalent mIDH1 inhibitor.
Zhao Cui, Jiameng Li, Caifeng Li, Mo Sun, Wei Liu, Xuxia Cao, Shiwen Deng, Junxian Cao, Hongjun Yang, Peng Chen   +9 more
wiley   +1 more source

Immune gene expression profiling of Proliferative Kidney Disease in rainbow trout Oncorhynchus mykiss reveals a dominance of anti-inflammatory, antibody and T helper cell-like activities [PDF]

, 2013
Peer reviewedPublisher ...
Gorgoglione, Bartolomeo, Holland, Jason W, Secombes, Christopher J, Wang, Tiehui   +3 more
core   +2 more sources

Regulatory B cells in the central nervous system: From immune regulation to neuroprotection

Neuroprotection, EarlyView.
Neuroinflammatory mechanisms and the therapeutic potential of regulatory B cells (Bregs). Following brain Injury (left panel) blood–brain barrier disruption facilitates the infiltration of peripheral leukocytes, including effector B cells (Beff) and effector T cells (Teff). This process triggers the activation of macrophages, astrocytes, and microglia,
Luiza Stanaszek, Miroslaw Janowski
wiley   +1 more source

The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. I. Surface immunoglobulin isotypes on primed B cells in the spleen

Journal of Experimental Medicine, 1977
We investigated the ability of IgM-, IgD-, and IgG-bearing cells from the spleens of (BALB/c x C57BL/Ka)F1 mice primed to dinitrophenyl- bovine serum albumin (DNP-BSA) to restore the adoptive secondary anti- BSA and anti-DNP antibody responses.
I. Zan‐Bar, S. Strober, E. Vitetta
semanticscholar   +1 more source

DNP-KLH yields weak large lymphocyte expansion and immunoglobulin isotype use with different immunization routes in zebrafish

Frontiers in Immunology, 2015
Distinct methods are required for inducing mucosal versus systemic immunity in mammals for vaccine protection at the tissues most commonly breached by pathogens.
Heather eWeir, Heather eWeir, Patricia L. Chen, Thaddeus C. Deiss, Natalie eJacobs, Mary B. Nabity, Matthew eYoung, Matthew eYoung, Michael F. Criscitiello   +8 more
doaj   +1 more source