Results 131 to 140 of about 20,447 (254)

Immunoglobulin isotype levels in mutant mice before and after OVA challenge.

, 2015
(A) Cox4i2tm1Hutt, (B) Ifit2tm1.1Ebsb and (C) Prdm11tm1.1ahl. Box plots show levels of immunoglobulin isotypes in the respective mutant mice and corresponding wild type littermates after OVA challenge.
Klaus T. Jensen (476411), Christophe Côme (109084), Lawrence I. Grossman (161192), Helmut Fuchs (39863), Anders H. Lund (163495), Christopher Sinkler (479901), Maik Hüttemann (479906), Erwin Bohn (152890), Valérie Gailus-Durner (125329), Johannes Beckers (76888), Icksoo Lee (479905), Cathrine Kolster-Fog (782193), Markus Ollert (271110), Martin Hrabĕ de Angelis (5657068), Juan Antonio Aguilar-Pimentel (782191), Marion Horsch (252388), Clemens Bönisch (782192)   +16 more
core   +1 more source

A rare presentation of type 2 hyper IgM syndrome in a 17-year-old male: a case report and literature review

Alergologia Polska
Hyper IgM syndrome (HIGM) is a heterogeneous group of primary immunodeficiencies characterized by impaired immunoglobulin class switching, leading to elevated IgM levels and deficiencies in other antibody isotypes.
Öner Özdemir, Lütfi Kılınçkaya, Ece Tüsüz Önata, Ali Yousef, Raziq Rahmani   +4 more
doaj   +1 more source

Anti-SARS-CoV-2 Immunoglobulin Isotypes, and Neutralization Activity Against Viral Variants, According to BNT162b2-Vaccination and Infection History. [PDF]

Front Immunol, 2021
Tarkowski M, de Jager W, Schiuma M, Covizzi A, Lai A, Gabrieli A, Corbellino M, Bergna A, Ventura CD, Galli M, Riva A, Antinori S.   +11 more
europepmc   +1 more source

Scaffold‐free three‐dimensional culture of chronic lymphocytic leukaemia preserves B–T‐cell cross‐talk and enables drug response profiling

British Journal of Haematology, EarlyView.
Summary Chronic lymphocytic leukaemia (CLL) presents a complex biological and clinical landscape, strongly influenced by the tumour microenvironment (TME). To better capture this heterogeneity, we have developed patient‐derived lymphoma spheroids from CLL samples (CLL‐PDLS), which recapitulate the cross‐talk between malignant cells and the autologous ...
Heribert Playa‐Albinyana, Ariadna Giró, Juan A. Piñeyroa, Ferran Araujo‐Ayala, Cèlia Dobaño‐López, Sara Otín‐Sánchez, Elías Campo, Christine Bezombes, Patricia Pérez‐Galán, Dolors Colomer   +9 more
wiley   +1 more source

Preformed antibody and complement rebound after plasma exchange: analysis of immunoglobulin isotypes and effect of splenectomy

, 1994
Splenectomy (Sx) has been proposed to attenuate post-PE (plasma exchange) rebound of isoagglutinins and xenogenic (XG) antibody (Ab) in both ABO-incompatible allografts and discordant xenografts. This study analyses the qualitative nature and kinetics of
Reding, Raymond, Tomasi, Jean-Paul, Latinne, Dominique, Baranski, Andrzej, Nisol, Françoise, Lambotte, Luc, Barker, Andrew, Bazin, Hervé, Soares, Miguel, Jamart, Jacques   +9 more
core   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Distribution of immunoglobulin isotypes and IgG subclasses in visceral leishmaniasis cases

, 2004
Visseral leishmaniasis erken tanısının zor olması, sağaltımda sıklıkla ilaç direnci ve relapslarla karşılaşılması nedeniyle, günümüzde halen sorun olmaya devam eden fatal, tropikal bir hastalıktır.
Tamer Şanlıdağ, Emin Limoncu, Özensoy Seray Töz, Sinem Akçalı, Yusuf Özbel, İ. Cüneyt Balcıoğlu   +5 more
core  

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Ketogenic Diet and β‐Hydroxybutyrate Suppress Bladder Cancer Growth and Enhance Anti‐PD‐L1 Immunotherapy Efficacy

Cancer Science, EarlyView.
Ketogenic diet and β‐hydroxybutyrate (β‐HB) suppress bladder cancer growth through direct anti‐tumor mechanisms and enhance anti‐PD‐L1 immunotherapy efficacy. β‐HB upregulates PD‐L1 via JAK2‐STAT3 activation and remodels the tumor immune microenvironment, sensitizing tumors to immune checkpoint blockade. ABSTRACT The limited clinical efficacy of immune
Yuan Zeng, Gangli Gu, Lin Yang, Bohao Fan, Haochen Cui, Lei Yan, Zhao Liu   +6 more
wiley   +1 more source

Identification and functional characterization of the novel MAR-binding protein, SATB2 [PDF]

, 2004
The regulation of gene expression is governed in large part by transcription factors that bind to enhancers and promoters. The functions of transcription factors involve both the modulation of chromatin accessibility via the recruitment of histone ...
Dobreva, Gergana
core