Results 141 to 150 of about 478,815 (317)

Presence of multiple isotypes on the surface of human tonsillar lymphocytes

, 1980
Formaldehyde-fixed small lymphocytes from human tonsils were investigated for the presence of the Ig heavy chain class isotypes ??, !c, ?? and ?? on their membranes by means of a direct immunofluorescence technique.
Vessiere-Louveaux, F.M.Y.R., Schuit, H.R.E., Hijmans, W.   +2 more
core  

Immunoglobulin isotype levels in mutant mice before and after OVA challenge.

, 2015
(A) Cox4i2tm1Hutt, (B) Ifit2tm1.1Ebsb and (C) Prdm11tm1.1ahl. Box plots show levels of immunoglobulin isotypes in the respective mutant mice and corresponding wild type littermates after OVA challenge.
Klaus T. Jensen (476411), Christophe Côme (109084), Lawrence I. Grossman (161192), Helmut Fuchs (39863), Anders H. Lund (163495), Christopher Sinkler (479901), Maik Hüttemann (479906), Erwin Bohn (152890), Valérie Gailus-Durner (125329), Johannes Beckers (76888), Icksoo Lee (479905), Cathrine Kolster-Fog (782193), Markus Ollert (271110), Martin Hrabĕ de Angelis (5657068), Juan Antonio Aguilar-Pimentel (782191), Marion Horsch (252388), Clemens Bönisch (782192)   +16 more
core   +1 more source

Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy

Allergy, EarlyView.
Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider, Juan‐Felipe López, Huseyn Babayev, Willem van de Veen, Minglin Yang, Cezmi A. Akdis, Kari Nadeau, Carolyn H. Baloh, Stacie M. Jones, Lisa M. Wheatley, Mübeccel Akdis, IMPACT, Amy M. Scurlock, D. Pesek, Joy Laurienzo‐Panza, Marshall Plaut, A. Wesley Burks, Edwin H. Kim, Mike Kulis, Anna Nowak‐Wegrzyn, Hugh A. Sampson, Julie Wang, Robert A. Wood, Sharon Chinthrajah, Robert Sayantani B. Sindher, Jacqueline Johnson, Katharine Spain, Denise C. Babineau, Hyunsook Chin, Rachel Yan, Don Whitehouse, Michelle L. Sever, Srinath Sanda, David Larson, Tielin Qin, Gina Marchesini, Kavitha Gilroy, Sylvia Posso, Sabrina Skiba, Thien‐Son Nguyen, Adam Wojno, Tuan Nguyen, Vivian Gersuk, Quynh‐Anh Nguyen, Jessica Garber, Kimberly O'Brien, Brandon Larson, C. Cousens‐Jacobs, Alex Hu   +48 more
wiley   +1 more source

Local immunoglobulin expression in myositis is associated with interferon gamma signaling and correlates with disease activity

OBJECTIVES: Autoantibodies may play a role in the pathogenesis of myositis and are locally produced within muscle tissue. This study aimed to characterize the local expression of immunoglobulin genes across different subgroups of myositis, identify ...
Pak, Katherine, Kirou, Raphael, Kirou, Raphael A., Naz, Faiza, Milisenda, Jose C., Metz, Caroline, Dell’Orso, Stefania, Islam, Shamima, Gutierrez-Cruz, Gustavo, Stenzel, Werner, Dell'Orso, Stefania, Selva-O’Callaghan, Albert, Pinal-Fernandez, Iago, Milisenda, José César, Casal-Dominguez, Maria, Selva O'Callaghan, Albert, Pinal Fernandez, Iago, Mammen, Andrew L.   +17 more
core   +1 more source

Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus

, 2010
To trace the emergence of modern IgA isotypes during vertebrate evolution we have studied the immunoglobulin repertoire of a model monotreme, the platypus.
K. Belov, M. Aveskogh, L. Hellman, Vernersson, Molly,, M. Vernersson, Aveskogh, Maria,, Hellman, Lars,, Belov, K.   +7 more
core   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Increased anergic B cells and decreased antibody‐secreting cells during romiplostim treatment in patients with immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Patients with immune thrombocytopenia (ITP) exhibit substantial heterogeneity in treatment responses. Approximately 30%–50% of patients maintain remission after discontinuation of thrombopoietin receptor agonists (TPO‐RA), suggesting immunomodulatory effects beyond enhanced thrombopoiesis.
Vivianne S. Nelson, Rebeca Gutiérrez‐Cózar, Rebecca Cornelis, S. Marieke van Ham, Anja ten Brinke, Rick Kapur   +5 more
wiley   +1 more source

Autoimmune neutropenia in children: Test cells versus beads and a role for pro‐LL‐37 and absolute neutrophil count

British Journal of Haematology, EarlyView.
A comparison between bead‐based and cell‐based assays for autoantibody detection in childhood neutropenia revealed substantial discordance between platforms. Bead‐based methods should be complemented with cell‐based methods for optimal diagnostic sensitivity. Incorporating pro‐LL‐37 and ANC measurements into the clinical workup of childhood neutropenia
Paul Ratcliffe, Alexandra Haara Löfstedt, Mikael Sundin, Petter Höglund   +3 more
wiley   +1 more source

Evaluation of Immunoglobulin Isotypes and Rh Factor Among Different Human Groups Located in Aden District, Republic of Yemen hasson

The aimed of this study was to determine quantitatively the immunoglobulin Isotypes IgM, IgA, and IgG level as well as rheumatoid factor among Yemeni blood donors.
Alsaadia, H, Shamsuldien, M, Hasson, SS
core   +2 more sources

Peanut‐Specific IgG4 mAbs Promote Regulatory Immune Responses Ex Vivo and Improve Oral Immunotherapy in Mice

Clinical &Experimental Allergy, EarlyView.
Allergen‐specific IgG4 mAbs were shown to block facilitated IgE binding to B cells and redirect allergens towards myeloid APC, leading to increased IL‐10 production in vitro. In combination with oral AIT, the mAbs inhibited mast cell activation and sustained allergen‐specific IgG4 levels in an in vivo model of peanut allergy. ABSTRACT Background Peanut
Pascal Gasser, Alex A. J. Overman, Mojtaba Porbahaie, Chiara Arena, Juliane Konrad, Renate Repke, Sandra Götschi, Dimitri Bieli, Tiziana Sonati, Alcide Barberis, Niccolò Pengo, R. J. Joost van Neerven, Natascha Wuillemin   +12 more
wiley   +1 more source