Results 91 to 100 of about 29,558 (298)

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

The kappa/lambda ratio of surface immunoglobulin light chain as a valuable parameter for MRD assessment in CLL with atypical immunophenotype

Scientific Reports
In recent years, the significance of detecting minimal/measurable residual disease (MRD) in chronic lymphocytic leukemia (CLL) has increased due to the availability of highly effective therapeutic agents.
Yu Aruga, Chiaki Ikeda, Hiromichi Matsushita, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Koji Izutsu, Hirotaka Matsui   +7 more
doaj   +1 more source

Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides [PDF]

, 2014
This article is under embargo for 12 months from the date of publication [Publication date: 7 Jan 2015] in accordance with publisher copyright policy.Recent advances in mass spectrometry-based proteomic methods have allowed variable (V)- region peptide ...
Al Kindi, Mahmood, Chataway, Timothy Kennion, Colella, Alex, Gilada, George A., Goldblatt, Fiona M., Gordon, Thomas Paul, Jackson, Michael W   +6 more
core   +1 more source

Engineered Bacterial Ligand From Streptococcus pneumoniae on Macroporous Resins for Selective Affinity Capture of Secretory IgA

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Secretory immunoglobulin A (sIgA) is a promising emerging biopharmaceutical candidate, but it currently lacks a standardized platform for purification. To address this, a novel affinity chromatography resin was developed by immobilizing protein variants of the Streptococcus pneumoniae surface protein, SpsA, as an affinity ligand.
David Scheich, Andres Männik, Oliver Meikar, Joan Teyra, Laura Kibena, Sebastiaan Eeltink, Rainer Hahn, Alois Jungbauer, Nico Lingg   +8 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Isolation and characterization of a light chain variable region gene for human rheumatoid factors. [PDF]

, 1987
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF ...
Carson, DA, Chen, PP, Jirik, FR, Kipps, TJ, Robbins, DL   +4 more
core  

Dual‐Field Synergistic Orientation of Carbon Fibers for High‐Efficiency Thermal Management

Carbon Energy, EarlyView.
The sample fabricated by synergistically combining reversed electric and low magnetic fields, with photocurable PEG/PPG gel serving as the matrix, exhibits excellent machinability and flexibility. Meanwhile, the thermal conductivity enhancement efficiency of this work is 1351%, significantly superior to similar carbon fiber composite materials ...
Zujian Zhao, Kang Xu, Yue Qin, Boren Yang, Kaiyuan Li, Linhong Li, Rongjie Yang, Yandong Wang, Hanxi Chen, Yiwei Zhou, Tao Cai, Cheng‐Te Lin, Kazuhito Nishimura, Maohua Li, Nan Jiang, Jinhong Yu   +15 more
wiley   +1 more source

Development of the PD9-9 Monoclonal Antibody for Identifying Porcine Bone Marrow-Derived Dendritic Cells

Life
The purpose of this study was to develop a monoclonal antibody (mAb) that can identify porcine dendritic cells (DCs) that have differentiated from bone marrow progenitor cells.
Sang Eun Kim, Young Kyu Kim, Keon Bong Oh, Jeong Ho Hwang   +3 more
doaj   +1 more source

A Case Report of Atypical Presentation of Multiple Myeloma on Serum Protein Electrophoresis [PDF]

Journal of Krishna Institute of Medical Sciences University, 2018
Multiple myeloma is a group of B-cell disorders resulting in the secretion of a specific and unique monoclonal immunoglobulin (M-protein). Protein electrophoresis is advised whenever multiple myeloma is suspected.
Pooja P. Padasal, Anil Malleshappa
doaj  

Light-Chain Deposition Disease with Prominent Hepatic Involvement [PDF]

, 2017
Light-chain deposition disease (LCDD) is a rare monoclonal gammopathy that involves the deposition of light chains (LC) in multiple organs, leading to progressive dysfunction. The kidney is usually the most affected organ and responsible for the initial
Carrola, Paulo, Cristino, Ana, Pais, Carmen, Silva, Renata   +3 more
core   +3 more sources