Results 221 to 230 of about 765,793 (291)

Application of the 2024 McDonald Criteria: Earlier Diagnosis and Avoiding Misdiagnosis of Multiple Sclerosis in a Global Setting. [PDF]

Neurology
Solomon AJ, Brownlee WJ, Viswanathan S, Fadda G, Fiol J, Galleguillos Goiry LM, Griffin T, Sahraian MA, Saylor DR, Rovira À, Flanagan EP, Ramanathan S, as the International Advisory Committee on Clinical Trials in Multiple Sclerosis.   +12 more
europepmc   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Intrathecal Kappa Free Light Chains in Relation to IgM Synthesis and MRZH Reaction in a Mixed Neurological Cohort. [PDF]

J Neurochem
Auf dem Brinke K, Thust NB, Simou A, Lattau SSJ, Lange P, Hansen N, Wallbach M, Fitzner D.   +7 more
europepmc   +1 more source

Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity

MedComm, Volume 7, Issue 9, September 2026.
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Zhu, Yixuan Sheng, Yun Chang, Yuan Chang, Miaomiao Xu, Wenjing Zhou, Wenxiu Wang, Qingyuan Liao, Zhan Shi, Meng Zhang, Feng Lan, Jiangping Song, Xiaoyan Qiu   +12 more
wiley   +1 more source

IgA Subclasses and Free Light Chains in Celiac Disease: A Pilot Study. [PDF]

Int J Mol Sci
Carnazzo V, Grieco V, Basile V, Redi S, Marino M, Ciasca G, Bondanini F, Basile U.   +7 more
europepmc   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Crystalglobulin-Induced Nephropathy and Cardiac Nonamyloidotic Immunoglobulin Deposition Disease: A Fatal Case Report. [PDF]

Kidney Med
Ushio Y, Manabe S, Seki M, Tanaka A, Suyama M, Nakai A, Kobayashi S, Makabe S, Kawaguchi Y, Ito N, Yoshizawa S, Haruki S, Yoshinaga K, Taneda S, Honda K, Hoshino J.   +15 more
europepmc   +1 more source

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

MedComm, Volume 7, Issue 9, September 2026.
SPR‐UPLC‐QTOF/MS‐GNPS‐guided screening identified hypermonol J (HPJ) as a high‐affinity TNF‐binding small molecule. HPJ may stabilize TNF dimers, reduce active trimer formation, and suppress TNFR1/NF‐κB signaling, thereby alleviating inflammatory pathology in psoriasis and acute lung injury models.
Yongqi Li, Weiguang Sun, Xingpiao Jin, Lanqin Li, Xiaotian Zhang, Pingping Fan, Yahui Huang, Chaohu Xiong, Jinsheng Wang, Jiangchun Wei, Yonghui Zhang, Zhengxi Hu   +11 more
wiley   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, Volume 4, Issue 3, Page 229-247, September 2026.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Inconsistency between serum IgG κ and glomerular IgA λ chain types in proliferative glomerulonephritis with monoclonal deposits successfully treated with daratumumab-based therapy. [PDF]

Medicine (Baltimore)
Chen H, Chen D, Zhang G, Cheng M, Jin J, Niu Z, Zhu R, Guo L, Wang J, Bai Y, Xu J, Cheng Z.   +11 more
europepmc   +1 more source