Results 101 to 110 of about 27,127 (159)

Navigating the evolving management of smoldering multiple myeloma

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Smoldering multiple myeloma (SMM) represents an intermediate clinical stage between monoclonal gammopathy of undetermined significance (MGUS) and symptomatic multiple myeloma (MM). SMM carries a highly variable risk of progression to MM, requiring individualized risk stratification to guide management.
M. Bakri Hammami, Rafael R. Canevarolo, Ariosto S. Silva, Melissa Alsina, Nagi Kumar, Rachid Baz, Kenneth H. Shain   +6 more
wiley   +1 more source

Recent advances in understanding and treating immunoglobulin light chain amyloidosis [version 1; referees: 2 approved]

F1000Research, 2018
Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in proteotoxicity and organ dysfunction.
Talha Badar, Anita D'Souza, Parameswaran Hari   +2 more
doaj   +1 more source

Treatment of IgM-associated immunoglobulin light-chain amyloidosis with rituximab-bendamustine.

Blood, 2018
TO THE EDITOR: Systemic amyloid light-chain amyloidosis (AL) is characterized by deposition of misfolded immunoglobulin light chains within organs. AL with an immunoglobulin M (IgM) monoclonal protein (IgM-AL) accounts for 5% to 7% of AL and exhibits ...
R. Manwani, S. Sachchithanantham, S. Mahmood, Darren Foard, F. Sharpley, T. Rezk, T. Lane, C. Quarta, M. Fontana, H. Lachmann, J. Gillmore, C. Whelan, P. Hawkins, A. Wechalekar   +13 more
semanticscholar   +1 more source

Bladder Amyloidosis With Pulmonary Lesions: A Case of Spontaneous Remission After Transurethral Resection

IJU Case Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Introduction Bladder amyloidosis is a rare condition characterized by amyloid fibril deposition in the bladder, often mimicking bladder cancer. Diagnosis requires histological analysis of the examination, and treatment typically involves transurethral resection. Case Presentation An 80‐year‐old male presented with gross hematuria.
Suguru Ito, Takuma Suzuki, Ryo Sato, Kunihiko Maeda, Shinta Suenaga, Hidenori Kanno, Sadanobu Sato, Shigemitsu Horie, Sei Naito, Norihiko Tsuchiya   +9 more
wiley   +1 more source

Cutaneous light chain amyloidosis and erythema elevatum diutinum as the presenting features of IgA monoclonal gammopathy: a rare case report and comprehensive literature review

Annals of Hematology
Monoclonal gammopathy (MG) associated with dermatological disorders, which is classified as monoclonal gammopathy of clinical significance (MGCS), represents a well-established complication.
Bing Han, Junfeng Zhou, Hesong Liu, Shanshan Li, Hong Wang   +4 more
doaj   +1 more source

Pulmonary light chain deposition disease: Case series and review of the literature

Radiology Case Reports
Pulmonary light chain deposition disease is a rare entity characterized by immunoglobulin deposition within the lung parenchyma with pathologic features distinct from pulmonary amyloidosis.
Tomas V. Gonzalez, MD, Anja C. Roden, MD, Brian J. Bartholmai, MD, Rebecca M. Lindell, MD   +3 more
doaj   +1 more source

Candidate genes of Waldenström’s macroglobulinemia: current evidence and research [PDF]

, 2014
Waldenström’s macroglobulinemia (WM) is a relatively uncommon, indolent malignancy of immunoglobulin M-producing B cells. The World Health Organization classifies it as a lymphoplasmacytic lymphoma and patients typically present with anemia ...
Bianchi, Giada, Ghobrial, Irene, Kumar, Shaji, Roccaro, Aldo, Rossi, Giuseppe, Sacco, Antonio   +5 more
core   +1 more source

Central nervous system involvement in cardiac amyloidosis: Redefining the heart‐brain axis

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Central nervous system involvement in cardiac amyloidosis. Amyloidosis is a systemic disease that can directly affect the central nervous system. Furthermore, the amyloid cardiomyopathy can indirectly affect the central nervous system by inducing systemic hypoperfusion and increasing the risk of acute ischaemic stroke.
Domenico Mario Giamundo, Giuliano Cassataro, Stefano Ministrini, Simon F. Stämpfli   +3 more
wiley   +1 more source

Rapid hematologic responses improve outcomes in patients with very advanced (stage IIIb) cardiac immunoglobulin light chain amyloidosis

Haematologica, 2018
Systemic AL amyloidosis (AL) is caused by deposition of misfolded immunoglobulin light chains, leading to potentially catastrophic visceral dysfunction.[1][1] Outcomes are heterogeneous, but cardiac involvement is a key survival predictor.
R. Manwani, Darren Foard, S. Mahmood, S. Sachchithanantham, T. Lane, C. Quarta, T. Youngstein, T. Rezk, H. Lachmann, J. Gillmore, M. Fontana, C. Whelan, P. Hawkins, A. Wechalekar   +13 more
semanticscholar   +1 more source

Light Chain Deposition Disease and Light Chain Cast Nephropathy in a Patient With Multiple Myeloma and HIV Infection: A Case Report

Case Reports in Nephrology, Volume 2026, Issue 1, 2026.
Kidney dysfunction is a common complication in multiple myeloma (MM), typically presenting with cast nephropathy as a single pattern of injury on kidney biopsy and infrequently occurs in people living with human immunodeficiency virus (PLHIV). A man in his 50s, newly diagnosed with HIV, who was admitted with community‐acquired pneumonia was found to ...
Tamzyn Huisamen, Liezel Coetzee, Mogamat-Yazied Chothia, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source