Results 81 to 90 of about 14,209 (224)

Extracellular volume quantification by dynamic equilibrium cardiac computed tomography in cardiac amyloidosis. [PDF]

, 2015
Cardiac involvement determines outcome in patients with systemic amyloidosis. There is major unmet need for quantification of cardiac amyloid burden, which is currently only met in part through semi-quantitative bone scintigraphy or Cardiovascular ...
Bandula, S, Fontana, M, Gilbertson, JA, Gillmore, JD, Hawkins, PN, Herrey, AS, Moon, JC, Punwani, S, Taylor, SA, Treibel, TA, White, SK   +10 more
core   +1 more source

Nuclear imaging and echocardiographic findings in hypertrophic cardiomyopathy with and without ATTR‐CM

ESC Heart Failure, EarlyView.
Abstract Aims Patients with transthyretin amyloid cardiomyopathy (ATTR‐CM) often experience delayed diagnosis, which may detrimentally impact clinical outcomes. This study aimed to assess the frequency of use of planar scintigraphy with and without single‐photon emission computed tomography (SPECT) in patients with hypertrophic cardiomyopathy (HCM ...
Pablo Garcia‐Pavia, Francisco Javier Haro del Moral, Francesco Cappelli, Nicolas Piriou, Roberto Barriales‐Villa, Carmen Munteanu, Catherine Bahus, Denis Keohane, Pablo Mallaina, Emmanuel Itti, Thibaud Damy, Perry Elliott   +11 more
wiley   +1 more source

A Case of Severe Cholestasis due to Hepatic AL Amyloidosis

GE: Portuguese Journal of Gastroenterology, 2019
Introduction: Immunoglobulin light chain-associated amyloidosis results from extracellular tissue deposition of fibril-forming monoclonal immunoglobulin light chains, secreted by a clone of plasma cells.
Teresa Dias, Diana Ferreira, Hélder Moreira, Telma Nascimento, Arsénio Santos, Armando Carvalho   +5 more
doaj   +1 more source

Critical Management Strategies for Cardiovascular Involvementin Light Chain Amyloidosis

罕见病研究, 2023
Light chain amyloidosis (AL) is a kind of rare disease. The misfolding of the light chain of monoclonal immunoglobulin forms amyloid substances and deposit in different tissues and organs, resulting in organ dysfunction.
SHI Yunjing, JIN Wei
doaj   +1 more source

Mandibular destructive radiolucent lesion: the first sign of multiple myeloma [PDF]

, 2016
The occurrence of a mandibular lesion as the first sign of multiple myeloma (MM) is uncommon. This report describes a case of MM diagnosed because of a mandibular lesion.
Fregnani, Eduardo Rodrigues, Leite, Amanda Almeida, Nesrallah, Ana Cristina Alo, Parahyba, Claudia Joffily, Perez, Danyel Elias da Cruz, Ramos Perez, Flávia Maria de Moraes   +5 more
core   +2 more sources

The Mayo ATTR‐CM score versus other diagnostic scores and cardiac biomarkers in patients with suspected cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Proposed algorithm to screen for transthyretin cardiac amyloidosis (ATTR‐CA). AL‐CA, immunoglobulin light‐chain cardiac amyloidosis; AMYLI, AMYLoidosis Index; AUC, area under the curve; IWT, increased wall thickness; LVEF, left ventricular ejection fraction; PYP, pyrophosphate.
Giovanni Battista Bonfioli, Daniela Tomasoni, Giuseppe Vergaro, Vincenzo Castiglione, Marianna Adamo, Iacopo Fabiani, Victor Loghin, Carlo Mario Lombardi, Alessio Nicolai, Marco Metra, Michele Emdin, Alberto Aimo   +11 more
wiley   +1 more source

Barriers to Small Molecule Drug Discovery for Systemic Amyloidosis

Molecules, 2021
Inhibition of amyloid fibril formation could benefit patients with systemic amyloidosis. In this group of diseases, deposition of amyloid fibrils derived from normally soluble proteins leads to progressive tissue damage and organ failure.
Gareth J. Morgan
doaj   +1 more source

Acute kidney injury on chronic kidney disease: From congestive heart failure to light chain deposition disease and cast nephropathy in multiple myeloma [PDF]

, 2019
Acute on chronic renal failure is a common but notably broad diagnosis. We present a 64-year-old man with a history of diastolic heart failure and chronic kidney disease, admitted for an elevated creatinine.
Cheng, Steven, Lacasse, Alexandre, Nwankwo, Christian, Shaikh, Sana   +3 more
core   +1 more source

Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature [PDF]

, 2016
Nodular pulmonary amyloidosis (NPA) is an uncommon pathology of insoluble protein depositing in pulmonary parenchyma. This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin light chain ...
Endicott, Kendal, Hsieh, Cindy M., Hynes, Conor, Paal, Edina, Trachiotis, Gregory D.   +4 more
core   +2 more sources

Diagnosing Smoldering Multiple Myeloma and Light Chain Amyloidosis in the Setting of Severe Transthyretin Amyloid Cardiomyopathy and Extracardiac Sarcoidosis

Annals of Internal Medicine: Clinical Cases
Light chain (AL) amyloidosis involves deposition of monoclonal immunoglobulin light chain-derived amyloid fibrils, whereas ATTR amyloidosis involves deposition of insoluble antiparallel beta-pleated protein within tissues, leading to organ-specific ...
Robert A. Churchill, Andrew Rosenbaum
doaj   +1 more source