Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus [PDF]
Objective The assessment system for monitoring systemic lupus erythematosus (SLE) disease activity is complex and lacks reliable laboratory indicators. It is necessary to find rapid and noninvasive biomarkers.
Jun Jiang, Jin Zhao, Dan Liu, Man Zhang
doaj +2 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova+4 more
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Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate. [PDF]
Intervention into amyloid deposition with anti-amyloid agents like the polyphenol epigallocatechin-3-gallate (EGCG) is emerging as an experimental secondary treatment strategy in systemic light chain amyloidosis (AL). In both AL and multiple myeloma (MM),
Andrich K+7 more
europepmc +2 more sources
Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong+4 more
doaj +1 more source
Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis? [PDF]
Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy.
Ana Marta António+3 more
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Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis
Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan+2 more
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Amyloidogenicity of Immunoglobulin Light Chains [PDF]
Systemic light chain amyloidosis (AL) is a rare protein aggregation disease. It usually strikes in the wake of myeloma, which affects plasma cells in the adaptive immune system. During plasma cell development, the immunoglobulin light chain (LC) genes undergo several rearrangements that leave each clone with a unique protein sequence.
Kathrin Andrich+4 more
openaire +2 more sources
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita+7 more
doaj +1 more source
Immunoglobulin light chain amyloidosis and the kidney [PDF]
Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Martha Q. Lacy+2 more
openaire +3 more sources
Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis
The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and organ dysfunction. Clinical and experimental advances have cast new light on the pathophysiology of damage in AL amyloidosis.
Francesca Lavatelli
doaj +1 more source