Results 41 to 50 of about 95,819 (354)
Serum Free Light Chains Removal by HFR Hemodiafiltration in Patients with Multiple Myeloma and Acute Kidney Injury. a Case Series [PDF]
, 2018 Background/Aims: Multiple myeloma (MM) represents 10% of all haematologic malignancies. Renal involvement occurs in 50% of MM patients; of them, 12-20% have acute kidney injury (AKI), with 10% needing dialysis at presentation. While hemodialysis (HD) has
Antolino, Giusy +7 more
core +2 more sources
Amyloidogenicity of Immunoglobulin Light Chains [PDF]
Biophysical Journal, 2015 Systemic light chain amyloidosis (AL) is a rare protein aggregation disease. It usually strikes in the wake of myeloma, which affects plasma cells in the adaptive immune system. During plasma cell development, the immunoglobulin light chain (LC) genes undergo several rearrangements that leave each clone with a unique protein sequence.
Andrich, Kathrin +4 more
openaire +1 more source
Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]
, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC +6 more
core +1 more source
Clinical Immunology CommunicationsObjectives: The objective of this study is to evaluate the use of the immunoglobulin heavy/light chain biomarker in the early detection of biochemical relapse in patients with multiple myeloma under treatment.
Carla Azevedo +11 more
doaj +1 more source
In Silico Prediction of Continuous Epitopes on Human immunoglobulin Light Chains [PDF]
Journal of Advanced Biomedical Sciences, 2020 Background & Objective: Immunoglobulins (Igs) have a vital role in body protection against germs. Igs contain heavy and light chains. Ig light chains consist of two isotypes: Kappa and lambda.
Soheyla Rohani, Fatemeh Hajighasemi
doaj
Regulated progression of B lymphocyte differentiation from cultured fetal liver. [PDF]
, 1987 Lymphoid fetal liver cultures (LFLC) are long-term, nontransformed cultures of early B lymphoid lineage cells which appear developmentally blocked at the pre-B stage in vitro.
Denis, KA, Dorshkind, K, Witte, ON
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2009 La nefropatía de las gammapatías monoclonales es debida, principalmente, al depósito de cadenas ligeras. Las enfermedades renales paraproteinémicas son lesiones asociadas con depósitos de inmunoglobulinas intactas o fragmentos de inmunoglobulinas ...
Jorge de Jesús Cantillo +2 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Novel Biomarkers of Inflammation for the Management of Diabetes: Immunoglobulin-Free Light Chains
Biomedicines, 2022 Virus infection, inflammation and genetic factors are important factors in the pathogenesis of diabetes mellitus. The nuclear factor-kappa B (NF-κB) is a family of transcription factors that bind the enhancer of the κ light chain gene of B cell ...
Akira Matsumori
doaj +1 more source