BioMedInformatics, 2023 Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj +1 more source
Evolution of antigen binding receptors [PDF]
, 1999 This review addresses issues related to the evolution of the complex multigene families of antigen binding receptors that function in adaptive immunity.
Anderson, Michele K. +2 more
core +1 more source
Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species
Frontiers in Immunology, 2022 Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora +5 more
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Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]
, 2012 Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V +9 more
core +5 more sources
Recommendations for use of free light chain assay in monoclonal gammopathies [PDF]
Journal of Medical Biochemistry, 2010 The serum immunoglobulin free light chain assay measures levels of free k and l immunoglobulin light chains. There are three major indications for the free light chain assay in the evaluation and management of multiple myeloma and related plasma cell ...
Radović Vesna V.
doaj
RAGs and Regulation of Autoantibodies [PDF]
, 2004 Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael +4 more
core +1 more source
B cell receptor accessory molecule CD79α : characterisation and expression analysis in a cartilaginous fish, the spiny dogfish (Squalus acanthias) [PDF]
, 2013 Copyright © 2013.
Anderson +78 more
core +2 more sources
Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]
, 2014 Peer reviewedPublisher ...
Barelle, Caroline +5 more
core +1 more source