Results 1 to 10 of about 321,783 (122)
Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. [PDF]
PLoS ONE, 2014 HIV-1 infection is complicated by high rates of opportunistic infections against which specific antibodies contribute to immune defense. Antibody function depends on somatic hypermutation (SHM) of variable regions of immunoglobulin heavy chain genes (VH ...
Elisabeth Bowers +7 more
doaj +3 more sources
Antigen-specific immunoglobulin variable region sequencing measures humoral immune response to vaccination in the equine neonate. [PDF]
PLoS ONE, 2017 The value of prophylactic neonatal vaccination is challenged by the interference of passively transferred maternal antibodies and immune competence at birth.
Rebecca L Tallmadge +3 more
doaj +3 more sources
Segmental duplication as one of the driving forces underlying the diversity of the human immunoglobulin heavy chain variable gene region [PDF]
BMC Genomics, 2011 Background Segmental duplication and deletion were implicated for a region containing the human immunoglobulin heavy chain variable (IGHV) gene segments, 1.9III/hv3005 (possible allelic variants of IGHV3-30) and hv3019b9 (a possible allelic variant of ...
Gao Richeng +7 more
doaj +2 more sources
mAbs, 2020 The antibody (Ab) germline gene rearrangement of variable (V), diversity (D), and joining (J) gene segments, as well as somatic hypermutation, give rise to the human Ab variable gene sequence repertoire.
Samuel Schmitz +3 more
doaj +1 more source
mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
doaj +1 more source
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Coupling finite and boundary element methods to solve the Poisson--Boltzmann equation for electrostatics in molecular solvation [PDF]
Journal of Computational Chemistry, 2023, 2023 The Poisson--Boltzmann equation is widely used to model electrostatics in molecular systems. Available software packages solve it using finite difference, finite element, and boundary element methods, where the latter is attractive due to the accurate representation of the molecular surface and partial charges, and exact enforcement of the boundary ...
arxiv +1 more source
Communications Biology, 2021 Lecerf et al. examine over 100 samples with variable region sequences matching clinical-stage immunoglobulin antibodies, to demonstrate that many interact with heme.
Maxime Lecerf +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Vast repertoires of unique antigen receptors are created in developing B and T lymphocytes. The antigen receptor loci contain many variable (V), diversity (D) and joining (J) gene segments that are arrayed across very large genomic expanses and are ...
Amy L. Kenter +2 more
doaj +1 more source
Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies [PDF]
, 2021 Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene. It also includes deletions and insertions of genomic material known as indels.
arxiv +1 more source