Results 21 to 30 of about 1,287,734 (381)

Comparison of microsatellite instability detection by immunohistochemistry and molecular techniques in colorectal and endometrial cancer

Scientific Reports, 2021
DNA mismatch repair deficiency (dMMR) testing is crucial for diagnosing Lynch syndrome and detection of microsatellite unstable (MSI) tumors eligible for immunotherapy.
F. Dedeurwaerdere, K. Claes, J. van Dorpe, I. Rottiers, Joni Van der Meulen, J. Breyne, Koen Swaerts, G. Martens   +7 more
semanticscholar   +1 more source

Correlation of 68Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study

Journal of Nuclear Medicine, 2021
Visual Abstract Fibroblast activation protein (FAP)–expressing cancer-associated fibroblasts confer treatment resistance and promote metastasis and immunosuppression.
Christine E. Mona, M. Benz, Firas Hikmat, T. Grogan, K. Lückerath, Aria A. Razmaria, Rana Riahi, R. Slavik, M. Girgis, G. Carlucci, K. Kelly, S. French, J. Czernin, D. Dawson, J. Calais   +14 more
semanticscholar   +1 more source

Crosstalk Between DNA Methylation and Gene Mutations in Colorectal Cancer

Frontiers in Oncology, 2021
Colorectal cancer (CRC) is often characterized by mutations and aberrant DNA methylation within the promoters of tumor suppressor genes and proto-oncogenes. The most frequent somatic mutations occur within KRAS and BRAF genes.
Maria Dobre, Alessandro Salvi, Iulia Andreea Pelisenco, Florina Vasilescu, Giuseppina De Petro, Vlad Herlea, Elena Milanesi   +6 more
doaj   +1 more source

Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997 [PDF]

, 2009
Using archived tumours, those from 1984-1986 and 1996-1997 underwent immunohistochemistry for hormone receptors and grade analysis. A significant shift towards more ER-positive and low-grade disease was found; this appears to reflect screening practices,
AG Glass, B Elsberger, CI Li, CS Thomson, E A Mallon, F M Campbell, GA Colditz, J Edwards, JD Potter, L M McGlynn, L Tabar, MJ Bradburn, P Pujol, S B F Brown, SBF Brown, T G Cooke, T Kirkegaard   +16 more
core   +2 more sources

Evaluation of metal contamination effects in piranhas through biomonitoring and multi biomarkers approach

Heliyon, 2020
The present field study aimed to assess the water quality of the Itacaiúnas River, located at the eastern part of the Brazilian Amazon, using water's physicochemical parameters, ecological risk assessment in sediments, biomarkers and metal ...
Caroline da Silva Montes, Maria Auxiliadora Pantoja Ferreira, Tommaso Giarrizzo, Lílian Lund Amado, Rossineide Martins Rocha   +4 more
doaj   +1 more source

Crocus sativus Extract as a Biological Agent for Disease-Modifying Therapy of Collagenase-Induced Mouse Model of Osteoarthritis

Life, 2023
Objectives: Osteoarthritis (OA) is an age-related joint disease that involves the degeneration of cartilage and is the most prevalent form of arthritis, affecting a large part of the population.
Blagovesta Boneva, Andrey Marchev, Kristiana Amirova, Petya Ganova, Milen Georgiev, Andrey Tchorbanov, Nikolina Mihaylova   +6 more
doaj   +1 more source

Aging Induces Changes in the Somatic Nerve and Postsynaptic Component without Any Alterations in Skeletal Muscles Morphology and Capacity to Carry Load of Wistar Rats

Frontiers in Neuroscience, 2017
The present study aimed to analyze the morphology of the peripheral nerve, postsynaptic compartment, skeletal muscles and weight-bearing capacity of Wistar rats at specific ages.
Walter Krause Neto, Wellington de Assis Silva, Adriano P. Ciena, Romeu R. de Souza, Carlos A. Anaruma, Eliane F. Gama   +5 more
doaj   +1 more source

Rapid micro-immunohistochemistry [PDF]

Microsystems & Nanoengineering, 2020
AbstractWe present a new and versatile implementation of rapid and localized immunohistochemical staining of tissue sections. Immunohistochemistry (IHC) comprises a sequence of specific biochemical reactions and allows the detection of specific proteins in tissue sections.
Robert D. Lovchik, David Taylor, Govind Kaigala   +2 more
openaire   +5 more sources

The XIIIth Banff Conference on Allograft Pathology: The Banff 2015 Heart Meeting Report: Improving Antibody-Mediated Rejection Diagnostics: Strengths, Unmet Needs, and Future Directions. [PDF]

, 2017
The 13th Banff Conference on Allograft Pathology was held in Vancouver, British Columbia, Canada from October 5 to 10, 2015. The cardiac session was devoted to current diagnostic issues in heart transplantation with a focus on antibody-mediated rejection
Angelini, A, Berry, GJ, Bruneval, P, Dragun, D, Duong Van Huyen, JP, Fedrigo, M, Haas, M, Loupy, A, Mengel, M, Miller, D, Potena, L, Reed, EF, Reinsmoen, N, Revelo, P, Smith, RN, Tebutt, S, Thum, T, West, L, Zeevi, A   +18 more
core   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
core   +2 more sources