The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
, 2013 Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura +14 more
core +3 more sources
Immunohistochemistry in Dermatopathology [PDF]
Archives of Pathology & Laboratory Medicine, 2015 ContextImmunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.ObjectiveTo review the current status and limitations of immunohistochemistry in dermatopathology.Data SourcesEnglish-language literature published between 1980 and 2014.ConclusionsAlthough immunohistochemistry is rarely ...
openaire +3 more sources
OUR EXPERIENCE OF IMMUNOHISTOCHEMICAL ASSAY IN BREAST CANCER
Паёми Сино, 2020 Objective: Analysis of the first experience of immunohistochemical (IHC) diagnostics of breast cancer (BC) in the Republic of Tajikistan for 2018- 2020. Methods: The results of the IHC study of tumor samples obtained by trephine biopsy in 142 patients
S.R. RASULOV, SH.A. VASIKHOV
doaj +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. [PDF]
, 2017 Malignant mesothelioma is a rare cancer that arises from the mesothelial cells that line the pleural cavity and less commonly from the peritoneal lining of the abdomen and pelvis.
Bastian, Boris C +10 more
core +2 more sources
Features of Appendix and the Characteristics of Appendicitis Development in Children with COVID-19
BiomedicinesBackground: Research on the subject of the influence of SARS-CoV-2 mechanisms on human homeostasis remains an actual problem. Particular interest is the study of pathomorphological changes in the appendix in children with COVID-19.
Grigory Demyashkin +11 more
doaj +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury [PDF]
, 2019 Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation ...
Carpino, Guido +15 more
core +3 more sources
Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from Apoptosis after serum withdrawal [PDF]
, 2013 Sciatic nerve (SN) transection-induced apoptosis of dorsal root ganglion neurons (DRGN) is one factor determining the efficacy of peripheral axonal regeneration and the return of sensation.
A Madro +48 more
core +5 more sources
Heliyon, 2020 The present field study aimed to assess the water quality of the Itacaiúnas River, located at the eastern part of the Brazilian Amazon, using water's physicochemical parameters, ecological risk assessment in sediments, biomarkers and metal ...
Caroline da Silva Montes +4 more
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