Journal of Genetic Engineering and Biotechnology, 2022 Background Among the most common causes of invasive aspergillosis and acute bronchopulmonary aspergillosis is Aspergillus fumigatus. Transmission with A.
Darakshan Jabin, Ajay Kumar
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Designing and Modelling of Trivalent Chimeric Vaccine for Capripoxvirus: Lumpy Skin Disease, Sheep Pox and Goat Pox by Immunoinformatics Approach [PDF]
, 2022 M. Pashupathi +6 more
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In silico designing of a novel polyvalent multi-subunit peptide vaccine leveraging cross- immunity against human visceral & cutaneous leishmaniasis: An Immunoinformatics-based approach [PDF]
, 2022 Mainak Bhattacharjee +2 more
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Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/−) Cervical Cancer
Journal of Medical Virology, Volume 97, Issue 8, August 2025.ABSTRACT Cervical cancer, a prevalent gynecological malignancy, is primarily associated with human papillomavirus (HPV) infection. However, some cases display distinct molecular alterations beyond HPV, significantly impacting the tumor immune microenvironment (TIME) and posing therapeutic challenges.
Qiongying Wang +7 more
wiley +1 more source
MicroorganismsDiagnosing canine visceral leishmaniasis (CVL) in Brazil faces challenges due to the limitations regarding the sensitivity and specificity of the current diagnostic protocol.
Gabriel Moreira +10 more
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Epitope-Based Immunoinformatic Approach on Heat Shock 70 kDa Protein Complex of Cryptococcus neoformans var. grubii [PDF]
, 2021 Reham M. Elhassan +8 more
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Immunoinformatics and Vaccine Development: An Overview.
ImmunoTargets and therapy, 2020 The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system.
Oli,Angus Nnamdi +7 more
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T-cell epitope vaccine design by immunoinformatics [PDF]
Open Biology, 2013 Vaccination is generally considered to be the most effective method of preventing infectious diseases. All vaccinations work by presenting a foreign antigen to the immune system in order to evoke an immune response. The active agent of a vaccine may be intact but inactivated (‘attenuated’) forms of the causative pathogens (bacteria or viruses), or ...
Atanas Patronov, Irini Doytchinova
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The FASEB Journal, Volume 39, Issue 11, 15 June 2025.Using the VirScan platform covering 4522 LSDV protein sequences, sera from 20 LSDV‐infected and 20 GTPV‐vaccinated cattle were used to screen phage libraries. Sequencing and bioinformatics analyses revealed peptides covering the TrLSDV103 protein. The candidate antigen was subsequently expressed, confirmed for its DIVA capability, and used to develop ...
Xinwei Yuan +5 more
wiley +1 more source
Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment
Journal of Peptide Science, Volume 31, Issue 6, June 2025.Peptides are increasingly used in diagnosis and treatment due to their selectivity and low side effects. Over 11% of FDA‐approved drugs from 2016 to 2024 were synthetic peptides. However, immunogenicity—an adverse immune response—can limit their safety and efficacy.
Koulla Achilleos +3 more
wiley +1 more source