Results 81 to 90 of about 8,611 (248)

A Genome‐Wide Screening of Novel Immunogenic TrLSDV103 Protein of Lumpy Skin Disease Virus and Its Application for DIVA

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
Using the VirScan platform covering 4522 LSDV protein sequences, sera from 20 LSDV‐infected and 20 GTPV‐vaccinated cattle were used to screen phage libraries. Sequencing and bioinformatics analyses revealed peptides covering the TrLSDV103 protein. The candidate antigen was subsequently expressed, confirmed for its DIVA capability, and used to develop ...
Xinwei Yuan, Junhua Dong, Zhijie Xiang, Qian Zhang, Pan Tao, Aizhen Guo   +5 more
wiley   +1 more source

T-cell epitope vaccine design by immunoinformatics [PDF]

Open Biology, 2013
Vaccination is generally considered to be the most effective method of preventing infectious diseases. All vaccinations work by presenting a foreign antigen to the immune system in order to evoke an immune response. The active agent of a vaccine may be intact but inactivated (‘attenuated’) forms of the causative pathogens (bacteria or viruses), or ...
Atanas Patronov, Irini Doytchinova
openaire   +3 more sources

ImmunoInformatics: at the crossroads between immunology and informatics, and beyond

ImmunoInformatics, 2021
Niels Halama, Doron Levy
doaj   +1 more source

Building immune digital twins: An international and transdisciplinary community effort

ImmunoInformatics
Digital twins, initially developed for industrial applications, are set to make significant advancements in medicine and healthcare. They have demonstrated promising potential for drug development and personalised care, especially in cardiovascular ...
Anna Niarakis, Gary An, Luiz Ladeira, Noriko F. Hiroi, Athina Papadopoulou, Francis P. Crawley, Niloofar Nikaein, Laurence Calzone, Eirini Tsirvouli, Hasan Balci, Marina Esteban Medina, Lorenzo Veschini, Ozan Ozisik, Francesco Messina, Malvina Marku, Van Du T. Tran, Arnau Montagud, Nikola Schlosserova, Yashwanth Subbannayya, Martina Kutmon, Michael L. Blinov, Rahuman S Malik Sheriff, Robert Phair, Peter Hunter, Kristin Reiche, Jasmin Fisher, Liesbet Geris, Yaron Ilan, James A. Glazier, Philippe Moingeon, Reinhard Laubenbacher   +30 more
doaj   +1 more source

Looming REF deadlines lead to a rush in publication of lower quality research [PDF]

, 2018
The increased significance of research assessments and their implications for funding and career prospects has had a knock-on effect on academic publication patterns. Moqi Groen-Xu, Pedro A.
Groen-Xu, Moqi, Knapp, Bernhard, Teixeira, Pedro, Voigt, Thomas   +3 more
core  

High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities. [PDF]

, 2016
T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an extremely diverse set of genes produced by imprecise somatic gene recombination. Massively parallel high-throughput sequencing allows millions of different T-
Alamyar, Aouinti, Attaf, Benati, Benny Chain, Brown, Covacu, Demotz, Ferret, Hall, Hou, Hung, James M. Heather, Kuchenbecker, Lefranc, Li, Li, Mazlina Ismail, Mori, Nazarov, Redmond, Robins, Tamura, Theres Oakes, Van Den Berg, Vanhanen, Wooldridge, Ye   +27 more
core   +1 more source

Beyond Efficacy: Ensuring Safety in Peptide Therapeutics through Immunogenicity Assessment

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
Peptides are increasingly used in diagnosis and treatment due to their selectivity and low side effects. Over 11% of FDA‐approved drugs from 2016 to 2024 were synthetic peptides. However, immunogenicity—an adverse immune response—can limit their safety and efficacy.
Koulla Achilleos, Christos Petrou, Vicky Nicolaidou, Yiannis Sarigiannis   +3 more
wiley   +1 more source

IApred: A versatile open-source tool for predicting protein antigenicity across diverse pathogens

ImmunoInformatics
Accurate prediction of protein antigenicity is crucial for vaccine development, diagnostic test design, and therapeutic protein engineering. However, existing tools face limitations in accessibility, computational efficiency, and pathogen diversity. Here,
Sebastian Miles, Gonzalo Menafra, Andrés Iriarte, Jose Alejandro Chabalgoity   +3 more
doaj   +1 more source

Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age [PDF]

, 2017
The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated ...
Britt G Jong, Bruno G Loos, Hanna IJspeert, Jacques JM Dongen, Lemelinda Marques, Menno C Zelm, Mirjam Burg, Zhang K   +7 more
core   +2 more sources

Plant‐Based Mycetoma Inhibitors Targeting the 50S Ribosomal Protein of Nocardia brasiliensis: In Silico Approach

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
In‐silico drug discovery pipeline for Mycetoma caused by Nocardia brasiliensis. A library of 1034 phytocompounds was screened to identify potent inhibitors, with Parviflorone F showing strong binding and stability against the 50S ribosomal unit. Molecular dynamics confirmed its inhibitory potential, offering a promising therapeutic candidate.
Sandra Jose, Manjunathan Jagadeesan, Meenambiga Setti Sudharsan, Pasiyappazham Ramasamy, Shyamala Gowri, Muthu Thiruvengadam, Sowmya Hari, Baskar Venkidasamy   +7 more
wiley   +1 more source