Results 21 to 30 of about 720,178 (345)
Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease [PDF]
Kidney Research and Clinical Practice, 2021 Background Endothelial cell (EC) dysfunction is a frequent feature in patients with end-stage renal disease (ESRD). The aim of this study was to generate human induced pluripotent stem cells, differentiate ECs (hiPSC-ECs) from patients with ESRD, and ...
Kyoung Woon Kim +7 more
doaj +1 more source
The Biological Influence and Clinical Relevance of Polymorphism Within the NKG2D Ligands
Frontiers in Immunology, 2018 NKG2D is a major regulator of the activity of cytotoxic cells and interacts with eight different ligands (NKG2DL) from two families of MIC and ULBP proteins.
Jianmin Zuo, Fiyaz Mohammed, Paul Moss
doaj +1 more source
Journal of Experimental Medicine, 2000 This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key role in T cell–mediated dominant immunologic self-tolerance.
Takeshi Takahashi +7 more
semanticscholar +1 more source
Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma
International Journal of Molecular Sciences, 2020 Asthma increases worldwide without any definite reason and patient numbers double every 10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but none of them inhibited airway wall remodeling in clinical studies.
L. Fang, Q. Sun, M. Roth
semanticscholar +1 more source
IMMUNOLOGY OF TUBERCULOSIS [PDF]
Mediterranean Journal of Hematology and Infectious Diseases, 2014 MTB ranks as the first worldwide pathogen latently infecting one third of the population and the second leading cause of death from a single infectious agent, after the human immunodeficiency virus (HIV). The development of vigorous and apparently appropriate immune response upon infection with M.tuberculosis in humans and experimental animals conflict
Bozzano F, Marras F, DE MARIA, ANDREA
openaire +4 more sources
A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell Activation in vivo
Frontiers in Immunology, 2018 Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity.
Hannah E. Scales +10 more
doaj +1 more source
The Immunological Synapse [PDF]
Cancer Immunology Research, 2003 AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
openaire +8 more sources
Immunologic correlates of the abscopal effect in a patient with melanoma.
New England Journal of Medicine, 2012 The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system.
M. Postow +20 more
semanticscholar +1 more source
Assessment of intracanal medications cytotoxicity on L929 fibroblast cells
Bioscience Journal, 2016 This study aimed to evaluate the cytotoxicity of intracanal medications on L929 fibroblast cells at different periods of observation. The following experimental groups were studied: calcium hydroxide with camphorated paramonochlorophenol and glycerin ...
Michelle de Paula Farias +6 more
doaj +3 more sources
The intersection of COVID-19 and autoimmunity: What is our current understanding?
Pathogens and Immunity, 2021 Viral infections have historically had a complex relationship with autoimmune diseases. For patients with preexisting autoimmune disorders, often complicated by immunosuppressive therapies, there are numerous potential effects of COVID-19, a disease of ...
Nicole Eve Winchester +2 more
doaj +1 more source