Results 41 to 50 of about 295,741 (152)

Infections in the Era of Targeted Therapies: Mapping the Road Ahead

Frontiers in Medicine, 2020
Immunosuppressive treatment strategies for autoimmune diseases have changed drastically with the development of targeted therapies. While targeted therapies have changed the way we manage immune mediated diseases, their use has been attended by a variety
Leonard H. Calabrese, Cassandra Calabrese, Tiphaine Lenfant, Tiphaine Lenfant, Tiphaine Lenfant, Elizabeth Kirchner, Vibeke Strand   +6 more
doaj   +1 more source

Immunology [PDF]

Journal of Clinical Pathology, 2005
Ian R, Sanderson, W Allan, Walker
openaire   +4 more sources

Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression

BMC Complementary and Alternative Medicine, 2019
Background We previously reported that tacrolimus (Tac) does not decrease T helper 17 cells (Th17) response in kidney transplantation. In this study, we evaluated whether Resveratrol (Resv) has immunosuppressive effects by decreasing Th17 responses in ...
Kyoung Chan Doh, Bo-Mi Kim, Kyoung Woon Kim, Byung Ha Chung, Chul Woo Yang   +4 more
doaj   +1 more source

Immune Thrombocytopenia: Immune Dysregulation and Genetic Perturbations Deciphering the Fate of Platelets

Frontiers in Bioscience-Landmark
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder. It involves impaired production and excessive destruction of platelets. It is a complex and heterogeneous disorder with unknown pathophysiology.
Zahra Tariq, Muhammad Imran Qadeer, Khadija Zahid, Elena Vladimirovna Cherepkova, Sayakhat Taurbekovich Olzhayev   +4 more
doaj   +1 more source

SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells

Cell Reports, 2018
A balance between Th17 and regulatory T (Treg) cells is critical for immune homeostasis and tolerance. Our previous work has shown Serum- and glucocorticoid-induced kinase 1 (SGK1) is critical for the development and function of Th17 cells. Here, we show
Chuan Wu, Zuojia Chen, Sheng Xiao, Theresa Thalhamer, Asaf Madi, Timothy Han, Vijay Kuchroo   +6 more
doaj   +1 more source

In vitro comparison of antioxidant, cytotoxic, and antibacterial (against Aggregatibacter actinomycetemcomitans) effects of Citrus reticulata, Olea europaea extracts, and essential oils

Dental Research Journal
Background: This study compared the antioxidant, cytotoxic, and antibacterial effects of Citrus reticulata (C. reticulata) peel and Olea europaea (O. europaea) leaf hydroalcoholic extracts and essential oils. Materials and Methods: In this in vitro study,
Surena Vahabi, Maryam Torshabi, Seyedeh Zahra Mirsharif   +2 more
doaj   +1 more source

Methotrexate-loaded multifunctional nanoparticles with near-infrared irradiation for the treatment of rheumatoid arthritis

Arthritis Research & Therapy, 2020
Backgrounds Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs.
You-Jung Ha, Sun-Mi Lee, Chin Hee Mun, Hyung Joon Kim, Yonghee Bae, Ji-Hee Lim, Kyu-Hyung Park, Soo-Kon Lee, Kyung-Hwa Yoo, Yong-Beom Park   +9 more
doaj   +1 more source

Recapitulation of methotrexate hepatotoxicity with induced pluripotent stem cell-derived hepatocytes from patients with rheumatoid arthritis

Stem Cell Research & Therapy, 2018
Background Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention.
Juryun Kim, Yena Kim, Jinhyeok Choi, Hyerin Jung, Kijun Lee, Jaewoo Kang, Narae Park, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju   +9 more
doaj   +1 more source

Transplantation Immunology

Pediatric Clinics of North America, 1994
A major function of the immune response is the discrimination of self from nonself. It is this response that must be overcome in transplant rejection. Progress in understanding these basic immune mechanisms has helped to improve clinical outcome and lays the foundation for a new generation of therapies.
A M, Krensky, C, Clayberger
openaire   +2 more sources

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Cell Reports, 2016
Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic.
Gerd Meyer zu Horste, Chuan Wu, Chao Wang, Le Cong, Mathias Pawlak, Youjin Lee, Wassim Elyaman, Sheng Xiao, Aviv Regev, Vijay K. Kuchroo   +9 more
doaj   +1 more source