Results 91 to 100 of about 55,587 (208)
ClinicoEconomics and Outcomes Research, 2023 Richard F Pollock,1 Andreas K Slættanes,2 Henrik Brandi,2 Tobias Sydendal Grand2 1Covalence Research Ltd, Harpenden, UK; 2ALK-Abelló A/S, Hørsholm, DenmarkCorrespondence: Andreas K Slættanes, ALK-Abelló A/S, Bøge Allé 1, Hørsholm, DK-2970, Denmark, Tel ...
Pollock RF +3 more
doaj
Efficacy of Biologics in Aspirin Exacerbated Respiratory Disease. [PDF]
Clin Transl AllergyABSTRACT Background Aspirin‐exacerbated respiratory disease (AERD), also termed nonsteroidal anti‐inflammatory drug exacerbated respiratory disease (NERD), is characterized by asthma, chronic rhinosinusitis with nasal polyposis, and hypersensitivity to cyclooxygenase‐1 inhibitors, frequently resulting in severe, treatment‐refractory airway disease ...
Priessnitz JK +4 more
europepmc +2 more sources
, 2001 Fast IPSCs in the brain are predominantly caused by presynaptic release of GABA that activates GABAAreceptor (GABAAR) channels. The IPSCs are shaped by the gating and desensitization properties of postsynaptic GABAARs.
Robert L. Macdonald +2 more
core +1 more source
, 2022 BackgroundDrug desensitization is helpful for patients who have experienced significant hypersensitivity reactions (HSRs) to antineoplastic agents. One-bag desensitization protocols, attracting attention in recent years, need to be validated on their ...
Hyunjee Kim (11950539) +8 more
core +1 more source
Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy
Allergy, EarlyView.Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan +16 more
wiley +1 more source
World Allergy Organization JournalBackground: While allergen-specific immunotherapy (AIT) is recognized as an effective treatment, its efficacy varies widely. However, whether clinical response trajectories to AIT differ among individuals and influence its effectiveness has not been ...
Pingan Zhang, MD +22 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan +5 more
wiley +1 more source
dopamine receptor desensitization
, 2002 Adenosine is known to modulate dopamine responses in several brain areas. Here, we show that tonic activation of adenosine receptors is able to impede desensitization of D1 dopamine receptors.
Delphine Prou +5 more
core +1 more source
Allergy, EarlyView.Gene expression of Ara h 2‐specific B cells over the course of the peanut OIT. Isotype of allergen‐specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen‐specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation.
Stephan R. Schneider +48 more
wiley +1 more source
Cow’s Milk Desensitization in Anaphylactic Patients: A New Personalized-dose Method
Iranian Journal of Allergy, Asthma and Immunology, 2017 Cow’s milk allergy (CMA) is the most frequent food allergy in children and oral immunotherapy (OIT) is a promising approach for treatment of patients.
Delara Babaie +13 more
doaj