Results 101 to 110 of about 55,587 (208)

receptor desensitization in CHO cells

, 2003
International audienceSerotonin 5-HT 4 receptor isoforms dier in their C-terminal tail and yet little is known about their regulation. In this study, we investigated the desensitization of two human 5-HT 4 receptors stably expressed in CHO cells, with a ...
Mialet, Jeanne, Frank Lezoualc'h, Rodolphe Fischmeister, Jeanne Mialet, Lezoualc'H, Frank, Fischmeister, Rodolphe   +5 more
core   +1 more source

Hypnosis and the Desensitization Behavior Therapies

, 1970
A distinction is made between desensitization techniques carried out in vivo and other modes of desensitization therapy (flooding, implosion, and systematic desensitization) which rely upon mental operations or processes. Research is reviewed and points
Stuart B. Litvak
core   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy

Allergy, EarlyView.
In this Phase 2a trial, severely peanut‐allergic participants were randomized to abatacept versus placebo with peanut oral immunotherapy (OIT) for 24 weeks, followed by 12 weeks of OIT alone. No significant difference was observed for the primary efficacy outcome (the relative change from baseline in peanut‐specific/total IgE ratio at 24 weeks), but ...
Marie‐Lee Simard, Camille Braun, Éloise Antony, Émilie Roy, Marie‐Ève Gingras, François Graham, Anne Des Roches, Louis Paradis, Kathryn Samaan, Florence Gingras‐Lessard, Roxane Labrosse, Thomas Eiwegger, Philippe Bégin   +12 more
wiley   +1 more source

Evaluation of total and specific IgE in serum of wheat allergy patients before and after of desensitization [PDF]

Background and Aim: Allergy to some food products is a usual affair which appears to be caused by immunologic and non immunologic reactions. One of the most important factors generating these reactions is mediating the IgE which can cause anaphylaxis ...
نبوی, محمد, رکابی, وهاب, ملاطفی, رسول, عرشی, صبا, رجبی, ابوالفضل, خوش میر صفا, مجید, رکابی, مهسا, بمانیان, محمد حسن, فلاح پور, مرتضی, صیف, فرهاد   +9 more
core  

Safety and Clinical Outcomes of High‐ Versus Low‐Dose Oral Peanut Immunotherapy in Polish Children With Peanut Allergy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To compare safety and clinical outcomes of two different oral immunotherapy (OIT) maintenance doses (150 mg vs. 300 mg) of peanut protein in children with peanut allergy. Methods This prospective study enrolled 44 children aged 4–17 years with confirmed peanut allergy.
Klementyna Łyżwa, Magdalena Chojnowska‐Wójtowicz, Wioletta Zagórska, Marek Kulus, Katarzyna Grzela   +4 more
wiley   +1 more source

Egg desensitization is achieved effectively and safely through a low maintenance dose protocol

Journal of Allergy and Clinical Immunology: Global
Background: Egg allergy is a common IgE-mediated food allergy in children. Oral immunotherapy (OIT) reduces allergic reactions via gradual allergen exposure.
Diana Toscano-Rivero, MD, Nofar Kimchi, MD, Wei Zhao, BSc, Jana Abi-Rafeh, BSc, Danbing Ke, PhD, Duncan Lejtenyi, MSc, Liane Beaudette, RN, Christine McCusker, MD, Bruce D. Mazer, MD, Moshe Ben-Shoshan, MD   +9 more
doaj   +1 more source

Physical urticarias: mast cell disfunction. Preventive, diagnostic and therapeutical approach [PDF]

Einstein (São Paulo), 2007
Objective: To present and discuss the current classification of physicalurticarias based on immunologic and pathophysiological mechanisms.To describe clinical symptoms, triggering and worsening factors,different diagnostic tools, and to list the ...
Mario Geller
doaj  

Antimicrobial Desensitization: A Review of Published Protocols

, 2019
Antimicrobial desensitization represents a last-line option for patients with no alternative therapies, where the benefits of this intensive process must outweigh the potential harm from drug exposure. The goal of antimicrobial desensitization procedures
Alegro, Chastain, Hutzley, Parekh
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source