Results 121 to 130 of about 55,587 (208)

Serum dilutions as a predictive biomarker for peri-operative desensitization: An exploratory approach to transplanting sensitized heart candidates.

, 2020
Antibody-mediated rejection (AMR) of cardiac allografts mediated by anti-HLA Donor Specific Antibodies (DSA) is one of the major barriers to successful transplantation for the treatment of end-stage heart failure.
Minakata, Kenji, Hamad, Eman, Keshavamurthy, Suresh, Timofeeva, Olga A, Hoosain, Jamael, MD, Rakita, Val, Pelberg, Justin, Toyoda, Yoshiya, Brisco, Meredith A, Brann, Stacey, Alvarez, Rene, Hassler, Jared, Yoon, Edward, Gomez-Abraham, Jesus, Alsammak, Mohamed, Geier, Steve S, Ruggia-Check, Christina, Afari-Armah, Nana   +17 more
core   +1 more source

Antibiotic desensitization in adults with cystic fibrosis

, 2003
Objective: Allergic reactions to antibiotics occur in up to 30% of patients with cystic fibrosis (CF). Repeated antibiotic exposure and immune hyper-responsiveness increase the risk of allergic reactions and may limit antibiotic choice.
Bell, S. C., Burrows, J. A., Toon, M.
core   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Biologics in IgE-mediated food allergy: A systematic review and meta-analysis of interventional studies

World Allergy Organization Journal
Background and aims: IgE-mediated food allergy (FA) is a major healthcare problem, affecting millions of children and adults worldwide. FA management usually involves elimination diets; however, there is increasing interest in alternative strategies that
Ulugbek B. Nurmatov, MSc, MPH, MD, PhD, Lucia Lo Scalzo, MD, Francesca Galletta, MD, Marianna Krasnenkova, MD, PhD, Stefania Arasi, MSc, MD, PhD, Ignacio J. Ansotegui, MD, PhD, Nara Tagiyeva-Milne, MD, MPH, PhD, Alessandro Fiocchi, MD   +7 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Considerations for biologics as front-line treatment in allergic diseases

Frontiers in Immunology
The therapeutic landscape of allergic diseases has been transformed by the advent of biologics targeting key immunologic pathways. These therapies offer disease-modifying potential across a spectrum of conditions including asthma, atopic dermatitis ...
Akash Kothari, Lisa Hung, Julia E. M. Upton, Julia E. M. Upton   +3 more
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Management of Highly Sensitized Patients in Renal Transplantation: Prospective Single-Center Study

Advanced Medical Journal
Background and objectives: In kidney transplantation, immunologic risk assessment was performed through pretransplant measurement of human leukocyte antigen, donor-specific antibodies.
Herish Othman Abdulrahman, Kais Hasan Abd   +1 more
doaj   +1 more source

Immunologic manifestations of autophagy

, 2015
The broad immunologic roles of autophagy span innate and adaptive immunity and are often manifested in inflammatory diseases. The immune effects of autophagy partially overlap with its roles in metabolism and cytoplasmic quality control but typically ...
Vojo Deretic, Deretic, Vojo, Pope Moseley, Michael Mandell, Santosh Chauhan, Chauhan, Santosh, Tomonori Kimura, Graham Timmins, Kimura, Tomonori, Mandell, Michael, Timmins, Graham, Moseley, Pope   +11 more
core   +1 more source