Results 1 to 10 of about 42,777 (163)

Antibody persistence and immunologic memory in children vaccinated with 4 doses of pneumococcal conjugate vaccines: Results from 2 long-term follow-up studies [PDF]

open access: yesHuman Vaccines & Immunotherapeutics, 2017
To investigate long-term antibody persistence following the administration of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV), we present results of 2 follow-up studies assessing antibody persistence ...
Jacek Wysocki   +10 more
doaj   +2 more sources

Single-cell profiling of T cells uncovers a tissue-resident memory-like T-cell subset associated with bidirectional prognosis for B-cell acute lymphoblastic leukemia

open access: yesFrontiers in Immunology, 2022
IntroductionThe character and composition of leukemia-related T cells are closely related to the treatment response and prognosis for patients. Though B cell-acute lymphoblastic leukemia (B-ALL) patients have benefited from immune-based approaches, such ...
Wenpu Lai   +15 more
doaj   +1 more source

Maintenance and recall of memory T cell populations against tuberculosis: Implications for vaccine design

open access: yesFrontiers in Immunology, 2023
Despite the widespread use of standardised drug regimens, advanced diagnostics, and Mycobacterium bovis Bacille-Calmette-Guérin (BCG) vaccines, the global tuberculosis (TB) epidemic remains uncontrollable. To address this challenge, improved vaccines are
Xin Liu   +4 more
doaj   +1 more source

Frequency of CXCR3+ CD8+ T-Lymphocyte Subsets in Peripheral Blood Is Associated With the Risk of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome Development in Advanced HIV Disease

open access: yesFrontiers in Immunology, 2022
BackgroundTuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a clinical aggravation of TB symptoms observed among a fraction of HIV coinfected patients shortly after the start of antiretroviral therapy (ART).
Rafael Tibúrcio   +32 more
doaj   +1 more source

CAR-T Cells with Phytohemagglutinin (PHA) Provide Anti-Cancer Capacity with Better Proliferation, Rejuvenated Effector Memory, and Reduced Exhausted T Cell Frequencies

open access: yesVaccines, 2023
The development of genetic modification techniques has led to a new era in cancer treatments that have been limited to conventional treatments such as chemotherapy.
Gamze Gulden   +8 more
doaj   +1 more source

Intradermal vaccination of adults with three low doses (2 µg) of recombinant hepatitis B vaccine. II. Persistence of immunity and induction of immunologic memory [PDF]

open access: yesMemorias do Instituto Oswaldo Cruz, 2003
Of the 110 dentists who had presented seroconversion 50 days after the intradermal application of three 2 µg doses of the Belgian recombinant vaccine against hepatitis B (HB), administered eight years before at an interval of one month between the 1st ...
Maria do Carmo M Elisbão   +8 more
doaj   +1 more source

Targeting memory T cell metabolism to improve immunity

open access: yesThe Journal of Clinical Investigation, 2022
Vaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens are often based on the efficiency of
Mauro Corrado, Erika L. Pearce
doaj   +1 more source

Redefining Non-Inferiority in Anamnestic Antibody Responses Using the Mean Increase of Log-Transformed Antibody Titers after Revaccination: Secondary Analysis of a Randomized Controlled Rabies Vaccination Trial

open access: yesVaccines, 2020
Non-inferiority in the anamnestic antibody response is conventionally determined by comparing seroconversion rates after revaccination. However, this approach is inadequate in the case of high pre-booster antibody titers.
Lisanne A. Overduin   +5 more
doaj   +1 more source

Exposure to SARS-CoV-2 and Infantile Diseases

open access: yesGlobal Medical Genetics, 2023
Background and Aim Immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in newborns and children after prophylactic immunization is currently a relevant research topic. The present study analyzes the issue by examining the
Darja Kanduc
doaj   +1 more source

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