Results 41 to 50 of about 26,657 (231)

Gut lactate-producing bacteria promote CD4 T cell recovery on Anti-retroviral therapy in HIV-infected patients

Computational and Structural Biotechnology Journal, 2021
Anti-retroviral therapy (ART) effectively suppresses viral replication in HIV-infected patients, however CD4 + cell restoration to normal value is not achieved by 15–20% of patients who are called immune non-responders.
Wei Lyu, Qingren Meng, Jingfa Xiao, Jing Li, Jian Wang, Zhifeng Qiu, Xiaojing Song, Hua Zhu, Changjun Shao, Yanan Chu, Qian Zhou, Taisheng Li, Routy Jean-Pierre, Jun Yu, Yang Han, Yu Kang   +15 more
doaj   +1 more source

Increased Microbial Translocation is a Prognostic Biomarker of Different Immune Responses to ART in People Living with HIV

Infection and Drug Resistance, 2023
Xuebin Tian,1,2,* Yiwen Xie,1,2,* Jingjing Chen,3,* Wanpeng Yin,1,2 Yu Long Zhao,1 Peng Yao,4 Mingqing Dong,4 Changzhong Jin,1,2 Nanping Wu1,2 1Cell Biology Research Platform, Jinan Microecological Biomedicine Shandong Laboratory, Jinan ...
Tian X, Xie Y, Chen J, Yin W, Zhao YL, Yao P, Dong M, Jin C, Wu N   +8 more
doaj  

The predictive role of CD4+ cell count and CD4/CD8 ratio in immune reconstitution outcome among HIV/AIDS patients receiving antiretroviral therapy: an eight-year observation in China

BMC Immunology, 2019
Background The immune reconstitution after initiation of highly active antiretroviral therapy (HAART) among HIV-infected individuals substantially affects patients’ prognosis.
Chong-Xi Li, Yu-Ye Li, Li-Ping He, Jing Kou, Jin-Song Bai, Jun Liu, Bo Tian, Li-Juan Cao, Kun-Hua Wang, Yi-Qun Kuang   +9 more
doaj   +1 more source

Novel DNA methylome biomarkers associated with adalimumab response in rheumatoid arthritis patients

Frontiers in Immunology, 2023
Background and aimsRheumatoid arthritis (RA) patients are currently treated with biological agents mostly aimed at cytokine blockade, such as tumor necrosis factor-alpha (TNFα).
Ishtu Hageman, Ishtu Hageman, Femke Mol, Sadaf Atiqi, Vincent Joustra, Hilal Sengul, Peter Henneman, Ingrid Visman, Theodorus Hakvoort, Mike Nurmohamed, Gertjan Wolbink, Evgeni Levin, Evgeni Levin, Andrew Y.F. Li Yim, Andrew Y.F. Li Yim, Andrew Y.F. Li Yim, Geert D’Haens, Wouter J. de Jonge, Wouter J. de Jonge   +18 more
doaj   +1 more source

Gut microbiota-associated non-cholesterol sterol dysregulation modulates immune reconstitution during antiretroviral therapy in people living with HIV

Microbiology Spectrum
Non-cholesterol sterol metabolism plays a crucial role in immune regulation. However, the non-cholesterol sterol profiles, its association with gut dysbiosis, and its impact on the CD4+ T cell recovery in people living with HIV (PLWH) are yet to be ...
Jingying Pan, Xuebin Tian, Kai Wu, Jia Ji, Mingqing Dong, Ting Sun, Dan Lv, Peng Yao, Longxian Lv, Hangping Yao   +9 more
doaj   +1 more source

Activation and gut-homing of peripheral T cells in HIV immunologic non-responders despite long term viral suppression

PLOS ONE, 2021
ObjectiveSerious non-AIDS disease events (SNAE) are experienced disproportionately by immunologic non-responders (INRs), HIV-infected individuals who do not restore CD4 T cells in blood despite effective viral suppression. We aimed to characterize the inflammatory biomarker profile of the INR phenotype.MethodsBlinded cross-sectional cohort study ...
Rodney K. Rousseau, Leah Szadkowski, Colin M. Kovacs, Michael F. Saikali, Rabea Nadeem, Fat Malazogu, Sanja Huibner, Carolyn L. Cummins, Rupert Kaul, Sharon L. Walmsley   +9 more
openaire   +4 more sources

HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction

, 2020
Abstract Background Human immunodeficiency virus (HIV)–infected immunological nonresponders (INRs) fail to reconstitute their CD4+ T-cell pool after initiation of antiretroviral therapy, and their prognosis is inferior to that of immunological responders (IRs).
Meyer-Myklestad, Malin Holm, Medhus, Asle Wilhelm, Lorvik, Kristina Berg, Seljeflot, Ingebjørg, Hansen, Simen Hyll, Holm, Kristian, Stiksrud, Birgitte, Trøseid, Marius, Hov, Johannes Espolin Roksund, Kvale, Dag, Dyrhol-Riise, Anne Ma, Kummen, Martin, Reikvam, Dag Henrik   +12 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Comparison of immunoresponse in PHB, YHB-vaccinee, and immunological background of non-responder.

Kanzo, 1990
B型肝炎ウイルスの院内感染予防を目的として医療従事者1,736名を対象に,人血漿由来HBワクチン(PHB vaccine)と遺伝子組替え酵母由来HBワクチン(YHB vaccine)の2種のワクチン接種を行い,その成績を比較した.併せてPHBワクチン接種群の抗体価の推移,および無反応例について細胞性免疫能を検討した.HBs抗体陽転率および獲得抗体価の対比では,PHBワクチン接種群の抗体陽転率は86%に留まったが,獲得抗体価は平均CI 97, (RIA法)であったのに対して,YHBワクチン接種群の陽転率は99%と高率であったが,獲得抗体価は平均CI 39, (RIA法)と低値であった.PHBワクチン接種群203例の抗体価の推移ほ9ヵ月後に平均55%の低下率を示した ...
Naoko TAKEUCHI, Yasutaka HOSHI, Kiyoshi FUJISAWA   +2 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source