Results 1 to 10 of about 31,523 (247)

Severe intestinal barrier damage in HIV-infected immunological non-responders

Heliyon, 2023
The intestinal epithelial barrier plays an important role during human immunodeficiency virus (HIV) disease progression. However, the extent to which the intestinal epithelial barrier is damaged in immunological non-responders (INRs) and immunological ...
Mengmeng Qu, Yaokai Chen
exaly   +5 more sources

Dysfunction and Metabolic Reprogramming of Gut Regulatory T Cells in HIV-Infected Immunological Non-Responders

Cells
Disruption of the gut microenvironment is a hallmark of HIV infection, where regulatory T cells (Tregs) play a critical role in maintaining gut homeostasis.
Mengmeng Qu, Chao Zhang, Xing Fan
exaly   +6 more sources

Abnormal characteristics of intestinal microenvironment in HIV immunological non-responders [PDF]

Frontiers in Immunology
Acquired immunodeficiency syndrome (AIDS) is one of the most dangerous diseases threatening global public health. Antiretroviral therapy (ART) is currently the primary treatment for people living with HIV (PLWH).
Huanxia Liu, Huanxia Liu, Yanguang Yang
doaj   +3 more sources

Characteristics and influencing factors of immunological non-responders in HIV-1-infected patients receiving antiretroviral therapy: a cross-sectional study in Guangxi

Scientific Reports
The prevalence of AIDS and mortality rates among HIV-infected individuals in Guangxi remain relatively high, potentially due to impaired CD4 + cell recovery. This study aims to identify factors hindering CD4 + cell recovery in people living with HIV.
Qiuying Zhu, Kailing Tang, Xianwu Pang   +2 more
exaly   +2 more sources

Immunological effects of subcutaneous and sublingual immunotherapy in house dust mite-allergic adults: a nine-month prospective pilot study [PDF]

Scientific Reports
House dust mite (HDM) allergy contributes to allergic rhinitis and asthma worldwide. Allergen-specific immunotherapy (AIT) is the only disease-modifying treatment, with immunoglobulin G4 (IgG4) and regulatory T cells (Tregs) mediating immune tolerance ...
Sara I. Taha, Aya Tollah Shaban, Afaf Abdelalim Mostafa, Sara S. Ghonaim, Lamyaa Salem   +4 more
doaj   +2 more sources

Incomplete functional T-cell reconstitution in immunological non-responders at one year after initiation of antiretroviral therapy possibly predisposes them to infectious diseases

International Journal of Infectious Diseases, 2019
Background: Immunological non-responders (INR) represent a unique category of HIV-infected patients on antiretroviral therapy. These patients have suppressed viremia but a suboptimal increase in CD4 cell count, which might have opposing effects on ...
Raman Gangakhedkar, Ashwini Shete, Girish Rahane   +2 more
exaly   +3 more sources

Immune cell subset profiling and metabolic dysregulation define the divergent immune microenvironments in HIV immunological non‐responders

Clinical and Translational Medicine
Background A subset of people living with HIV (PLWH) exhibit poor immune recovery despite effective antiretroviral therapy (ART), remaining at risk of disease progression.
Qingfei Chu
exaly   +2 more sources

Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population

Diagnostics
Approximately 10–35% of people living with HIV (PLHIV) on antiretroviral therapy (ART) fail to restore CD4+ T cell counts, a state known as immunological non-responder (INR) characterized by persistent immune activation and elevated cytokine levels ...
Anton Sumarpo, Dewi Kartika Turbawaty, Fitri Fadhilah   +2 more
exaly   +3 more sources

Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders

MBio
Despite long-term suppressive antiretroviral therapy (ART), immune dysregulation due to impaired reconstitution of CD4+ T cells is a major hurdle for reducing morbidity and mortality in HIV-1-infected immunological non-responders (INRs, CD4+ T cells ≤350
Udaykumar Ranga, Manjunatha Venkataswamy   +1 more
exaly   +3 more sources

Oral Microbiota Is Associated With Immune Recovery in Human Immunodeficiency Virus-Infected Individuals

Frontiers in Microbiology, 2021
The role of the oral microbiota in HIV-infected individuals deserves attention as either HIV infection or antiretroviral therapy (ART) may have effect on the diversity and the composition of the oral microbiome.
Yirui Xie, Jia Sun, Caiqin Hu, Bing Ruan, Biao Zhu   +4 more
doaj   +1 more source