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The immunological synapse as a pharmacological target
Pharmacological Research, 2018 Graphical abstract Figure. No caption available. &NA; The development of T cell mediated immunity relies on the assembly of a highly specialized interface between T cell and antigen presenting cell (APC), known as the immunological synapse (IS).
F. Finetti, C. Baldari
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Science Signaling, 2023
Engagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell–mediated immune responses. Blocking such signaling provides the clinical effects of PD-1–targeted immunotherapy.
Noémie Paillon +8 more
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Engagement of the receptor programmed cell death molecule 1 (PD-1) by its ligands PD-L1 and PD-L2 inhibits T cell–mediated immune responses. Blocking such signaling provides the clinical effects of PD-1–targeted immunotherapy.
Noémie Paillon +8 more
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A check on the immunological synapse
Science Signaling, 2023Blocking Nogo receptor 1 on natural killer cells enhances cell killing by stabilizing contact with target cells.
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The diversity of immunological synapses
Current Opinion in Immunology, 2003Immunological synapses (ISs) are specialised signalling domains characterised by complex molecular clustering and segregation at the contact site between cells of the immune system. T lymphocytes form different ISs depending on their state of activation and on the antigen-presenting cells with which they interact. The structural features of the various
Alain, Trautmann, Salvatore, Valitutti
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Communication, the centrosome and the immunological synapse [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in ...
Jane C Stinchcombe, Gillian M Griffiths
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Plasticity of Immunological Synapses
2009TCR engagement with peptide/MHC complexes displayed on the surface of the antigen-presenting cells is the crucial event in developing an adaptive immune response and occurs within specialized signaling areas named immunological synapses. Immunological synapses are diverse both in structure and function and exhibit a strikingly dynamic molecular ...
Salvatore, Valitutti, Loïc, Dupré
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[Immunological synapses and neuronal synapses].
Medecine sciences : M/S, 2003The interface between two cells from the immune system has recently been coined "immunological synapse". The authors review recent findings concerning the structure of the synapse formed between T lymphocytes and antigen-presenting cells. T cells can be part of different synapses, depending on the antigen-presenting cell (B cell hybridoma, proteo-lipid
Alain, Trautmann +3 more
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Archivum immunologiae et therapiae experimentalis, 2004
The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity.
Klemmensen, Thomas +2 more
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The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity.
Klemmensen, Thomas +2 more
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The Immunological Synapse and Rho GTPases
2005Rho GTPases are molecular switches controlling a broad range of cellular processes including lymphocyte activation. Not surprisingly, Rho GTPases are now recognized as pivotal regulators of antigen-specific T cell activation by APCs and immunological synapse formation.
M, Deckert, C, Moon, S, Le Bras
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Purinergic signaling at immunological synapses
Journal of the Autonomic Nervous System, 2000The early studies and hypotheses of Geoffrey Burnstock catalyzed intensive characterization of roles for nucleotides and P2 nucleotide receptors in neurotransmission and neuromodulation. These latter analyses have focused on the mechanisms of nucleotide release and action in the microenvironments of nerve endings and synapses.
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