Results 291 to 300 of about 52,207 (332)
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Molecular Immunology, 2002
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
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The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
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Imaging Immunological Synapses
Science's STKE, 2000Immunological synapses arise at contact zones between antigen-presenting cells and T cells. Synapses have distinct organization and are composed of T cell receptors interacting with major histocompatibility complex-peptide entities surrounded by various potentiating coreceptors and signaling molecules that migrate into the synapse through ...
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Plasticity of Immunological Synapses
2009TCR engagement with peptide/MHC complexes displayed on the surface of the antigen-presenting cells is the crucial event in developing an adaptive immune response and occurs within specialized signaling areas named immunological synapses. Immunological synapses are diverse both in structure and function and exhibit a strikingly dynamic molecular ...
Salvatore, Valitutti, Loïc, Dupré
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Immunological Synapse Regulation
Science, 2003The immunological synapse coordinates intercellular communication between T cells and antigen-presenting cells, but the signaling functions of this structure have not been clear. Experiments and computer modeling have led Lee et al.
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The diversity of immunological synapses
Current Opinion in Immunology, 2003Immunological synapses (ISs) are specialised signalling domains characterised by complex molecular clustering and segregation at the contact site between cells of the immune system. T lymphocytes form different ISs depending on their state of activation and on the antigen-presenting cells with which they interact. The structural features of the various
Alain, Trautmann, Salvatore, Valitutti
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A check on the immunological synapse
Science Signaling, 2023Blocking Nogo receptor 1 on natural killer cells enhances cell killing by stabilizing contact with target cells.
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Signaling and the Immunological Synapse
2010This chapter deals with T cell activation and immunological synapses. It begins with a brief summary of T cell biology to put a discussion of immune synapses into a broader context because the study of immunological synapses addresses issues pertaining mainly to the field of cellular immunology.
Giurisato, Emanuele, Shaw, Andrey S.
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[Immunological synapses and neuronal synapses].
Medecine sciences : M/S, 2003The interface between two cells from the immune system has recently been coined "immunological synapse". The authors review recent findings concerning the structure of the synapse formed between T lymphocytes and antigen-presenting cells. T cells can be part of different synapses, depending on the antigen-presenting cell (B cell hybridoma, proteo-lipid
Alain, Trautmann +3 more
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Archivum immunologiae et therapiae experimentalis, 2004
The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity.
Klemmensen, Thomas +2 more
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The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity.
Klemmensen, Thomas +2 more
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Purinergic signaling at immunological synapses
Journal of the Autonomic Nervous System, 2000The early studies and hypotheses of Geoffrey Burnstock catalyzed intensive characterization of roles for nucleotides and P2 nucleotide receptors in neurotransmission and neuromodulation. These latter analyses have focused on the mechanisms of nucleotide release and action in the microenvironments of nerve endings and synapses.
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