Results 281 to 290 of about 52,207 (332)
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
MedComm, Volume 7, Issue 5, May 2026.Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
Maternal Chrono‐Nutrition and Placental DNA Methylation: The BiSC Study
Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.This is the first study to examine how the timing of a mother's meals during pregnancy relates to changes in placental DNA methylation, an epigenetic mark. We found that the timing of the last daily meal was most important. Some epigenetic changes were linked to genes involved in placental function and development, and the long‐term health consequences
Joana Llauradó‐Pont +12 more
wiley +1 more source
PROTEOMICS, Volume 26, Issue 5, Page 86-97, May 2026.ABSTRACT Absence of the endosomal SNAREs vti1a and vti1b results in perinatal death and severe neuronal phenotypes in mice, while lack of one of these proteins results in minor phenotypes. Proteomic differences were investigated to obtain a deeper insight into processes in which vti1a and vti1b are involved.
Julia Gottschalk +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.We propose a roadmap to guide the development of rejuvenation therapeutics integrating replacement‐based ageing interventions, regeneration, and synthetic technologies that remove or export hundreds of types of molecular, organellar, and cellular damage.
Bjorn Fraser Olaisen +12 more
wiley +1 more source
Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 477-489, May 2026.ABSTRACT Background and Hypothesis Deficits in processing speed (PS) and psychomotor speed (PMS) are core cognitive impairments in schizophrenia spectrum disorders, including first‐episode psychosis (FEP). Neuroinflammation has been proposed as a potential contributor to these deficits.
Ángel Yorca‐Ruiz +8 more
wiley +1 more source
Blood‐Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder
Addiction Biology, Volume 31, Issue 5, May 2026.This study represents the first epigenome‐wide association analysis of Alcohol Use Disorder (AUD) in a genetically and culturally diverse Brazilian cohort. Genome‐wide DNA methylation profiling revealed hypomethylation in genes and pathways related to neuronal development, synaptic organization, intracellular signaling and cellular stress responses in ...
Laís da Silva Pereira‐Rufino +15 more
wiley +1 more source
Immunology. The immunological synapse--a multitasking system.
Science (New York, N.Y.), 2002 Van Der Merwe, P, Davis, S
openaire +2 more sources
Biology of the Cell, Volume 118, Issue 5, May 2026.Glioblastoma U251MG cells were cultured in 2D monolayers and 3D spheroids to model tumor architecture. Comparative LC–MS/MS proteomics identified proteins associated with chemoresistance in 3D conditions. Selected candidates were functionally validated by gene knockdown and drug sensitivity assays to confirm their roles in modulating glioblastoma ...
Wannawat Khotchawan +6 more
wiley +1 more source
Opioids in breast cancer: Between analgesia and modulation of tumour progression
British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source