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Modeling presynaptic inhibition by the amyloid precursor protein demonstrates one potential mechanism for preventing runaway synaptic modification in Alzheimer's disease. [PDF]
Barber D, Hasselmo ME, Rice HC.
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Diatom-Based Artificial Antigen-Presenting Cells: A Novel Approach for Adaptive Immune Modulation. [PDF]
Abdul Rahman A +3 more
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Emerging roles of astrocytes in hippocampal circuitry and behavior. [PDF]
Squires A, Park J.
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Reframing adjuvant immunotherapy in melanoma: all of it starts with priming. [PDF]
Ascierto PA, Melero I.
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Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue. [PDF]
Ciobanu AC +11 more
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Molecular Immunology, 2002
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
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The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
openaire +2 more sources
Imaging Immunological Synapses
Science's STKE, 2000Immunological synapses arise at contact zones between antigen-presenting cells and T cells. Synapses have distinct organization and are composed of T cell receptors interacting with major histocompatibility complex-peptide entities surrounded by various potentiating coreceptors and signaling molecules that migrate into the synapse through ...
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Plasticity of Immunological Synapses
2009TCR engagement with peptide/MHC complexes displayed on the surface of the antigen-presenting cells is the crucial event in developing an adaptive immune response and occurs within specialized signaling areas named immunological synapses. Immunological synapses are diverse both in structure and function and exhibit a strikingly dynamic molecular ...
Salvatore, Valitutti, Loïc, Dupré
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