Results 141 to 150 of about 79,221 (241)

Corrigendum to "Skin-inspired phototherapeutic cryogel ameliorates infected wound healing by orchestrating mechanotransduction and immunomodulation" [Bioact. Mater. 57 (2026) 768-790]. [PDF]

Bioact Mater
Dutta SD, An JM, Moniruzzaman M, Acharya R, Seol Y, Kim H, Randhawa A, Kim JS, Lee YK, Lim KT.   +9 more
europepmc   +1 more source

Understanding the influence of transfusion and blood loss on tranexamic acid concentration in scoliosis surgery with blood loss

British Journal of Clinical Pharmacology, EarlyView.
Aims Tranexamic acid (TXA) stabilizes clot formation by inhibiting fibrin degradation and improves postoperative outcomes. However, rare adverse events (e.g., thrombosis, seizures) warrant dose–risk evaluation. This study examines how perioperative blood loss and transfusion practices affect TXA concentrations during paediatric scoliosis surgery ...
Paula Alexandra Sá, Luisa Barreiros, Marcela A. Segundo, Eugénia Cruz, Sibylle Langenecker   +4 more
wiley   +1 more source

Editorial: Exploring immunomodulation to balance maladaptive inflammation and restore tissue homeostasis. [PDF]

Front Immunol
Smadja DM, Jeljeli M, Lellouch AG.
europepmc   +1 more source

Harnessing Cellular Feeling: Epigenetic to Mechanical Memory as a Framework for Stem Cell Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stem cell‐based therapies hold transformative potential for regenerative medicine, yet their progress is constrained by persistent variability in manufacturing and clinical performance. Conventional frameworks such as Quality by Design (QbD), though effective for drugs and biologics, struggle to accommodate the dynamic nature of living cell ...
Mee‐Hae Kim, Masahiro Kino‐oka
wiley   +1 more source

Immunomodulation: precision targeting for restoring immune homeostasis and therapeutic applications. [PDF]

Essays Biochem
Xu F, Wang C.
europepmc   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Corrigendum: Endothelial β-catenin deficiency causes blood-brain barrier breakdown via enhancing the paracellular and transcellular permeability

Frontiers in Molecular Neuroscience
Basharat Hussain, Basharat Hussain, Cheng Fang, Xiaowen Huang, Ziying Feng, Ziying Feng, Yuxuan Yao, Yu Wang, Junlei Chang   +8 more
doaj   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Current regulatory requirements for assessment of immunogenicity for gene therapy medicinal products. [PDF]

Cell Rep Med
Mann CJ, Giblin J, Braun M, Schmid F, Sørensen MR, Caferra P, Hudák A, Letoha T, Coderch N, Hickling TP, Azzouz M.   +10 more
europepmc   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source